A5062432567- Salivary Gland Disorders and Functions
- Salivary Gland Tumors Diagnosis and Treatment
- Oral health in cancer treatment
- Head and Neck Cancer Studies
- Oral Health Pathology and Treatment
- Cancer Diagnosis and Treatment
- Oral microbiology and periodontitis research
- Dental Radiography and Imaging
- Systemic Sclerosis and Related Diseases
- Temporomandibular Joint Disorders
- Oral and gingival health research
- Facial Trauma and Fracture Management
- Dental Implant Techniques and Outcomes
- Orthodontics and Dentofacial Orthopedics
- Systemic Lupus Erythematosus Research
- Oral and Maxillofacial Pathology
- Ocular Surface and Contact Lens
- HIV/AIDS oral health manifestations
- Diabetes and associated disorders
- Total Knee Arthroplasty Outcomes
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Growth Hormone and Insulin-like Growth Factors
- Reconstructive Surgery and Microvascular Techniques
- Spinal Fractures and Fixation Techniques
- Glycosylation and Glycoproteins Research
University Medical Center Groningen
2016-2025
University of Groningen
2016-2025
National Medical Research Center of Dentistry and Maxillofacial Surgery
2006-2023
Merem
2023
Dialyse Centrum Groningen
2014-2022
Brigham and Women's Hospital
2001-2007
The University of Adelaide
2007
Royal Adelaide Hospital
2007
Statistical Service
2006
Martini Ziekenhuis
2004
PURPOSE: To explore the relationship between oral mucositis and selected clinical economic outcomes in blood marrow transplant patients. PATIENTS AND METHODS: Subjects consisted of 92 patients from eight centers who participated a multinational pilot study new scoring system (Oral Mucositis Assessment Scale [OMAS]). In study, were evaluated for erythema ulceration/pseudomembrane formation beginning on first day conditioning continuing 28 days. We examined patients’ peak OMAS scores days with...
Abstract Objective To investigate the safety and efficacy of B cell depletion treatment patients with active primary Sjögren's syndrome short duration (early SS) SS mucosa‐associated lymphoid tissue (MALT)–type lymphoma (MALT/primary SS). Methods Fifteen were included in this phase II trial. Inclusion criteria for early group hyperactivity (IgG >15 gm/liter), presence autoantibodies (IgM rheumatoid factor, anti‐SSA/SSB), disease (<4 years). MALT/primary an associated MALT‐type (Ann...
Abstract Objective To study the efficacy and safety of B cell depletion with rituximab, a chimeric murine/human anti‐CD20 monoclonal antibody, in patients primary Sjögren's syndrome (SS) double‐blind, randomized, placebo‐controlled trial. Methods Patients active SS, as determined by revised American–European Consensus Group criteria, rate stimulated whole saliva secretion ≥0.15 ml/minute were treated either rituximab (1,000 mg) or placebo infusions on days 1 15. assigned randomly to...
Abstract Background: Currently, a large variety of classifications is used for periodontitis as risk factor other diseases. None these quantifies the amount inflamed periodontal tissue, while this information needed to assess inflammatory burden posed by periodontitis. Aim: To develop classification that which can be easily and broadly applied. Material Methods: A literature search was conducted look quantified tissue. root surface area affected attachment loss found. This did not quantify...
BACKGROUND An impediment to mucositis research has been the lack of an accepted, validated scoring system. The objective this study was design, test, and validate a new system for that can be used easily, is reproducible, provides accurate applications. METHODS A panel experts, convened design objective, simple, reproducible assessment tool evaluate with specific application multicenter clinical trials, developed scale measured subjective indicators mucositis. Nine centers participated in...
Abstract BACKGROUND. The risk, severity, and patient‐reported outcomes of radiation‐induced mucositis among head neck cancer patients were prospectively estimated. METHODS. A validated, questionnaire (OMDQ), the FACT quality life (QOL), Functional Assessment Chronic Illness Therapy (FACIT) fatigue scales used to measure (reported as mouth throat soreness), daily functioning, use analgesics. Patients studied before radiotherapy (RT), during RT, for 4 weeks after RT. RESULTS. Contrary previous...
<h3>Objective</h3> To assess the efficacy and safety of abatacept in patients with early active primary Sjögren9s syndrome (pSS). <h3>Methods</h3> All 15 (12 women, three men) included open-label Active Sjögren Abatacept Pilot study met revised American-European Consensus Group criteria for pSS were biological disease-modifying antirheumatic drug-naive. Patients treated eight intravenous infusions on days 1, 29 every 4 weeks thereafter. Follow-up was conducted at 4, 12, 24 (on treatment), 36...
Alterations in the microbiota composition of gastro-intestinal tract are suspected to be involved etiopathogenesis two closely related systemic inflammatory autoimmune diseases: primary Sjögren's syndrome (pSS) and lupus erythematosus (SLE). Our objective was assess whether alterations gut oral compositions specific for pSS SLE.16S ribosomal RNA gene sequencing performed on fecal samples from 39 patients, 30 SLE patients 965 individuals general population, as well buccal swab washing same...
To compare health-related quality of life (HR-QOL), employment and disability primary secondary SS (pSS sSS, respectively) patients with the general Dutch population.HR-QOL, were assessed in regularly attending University Medical Center Groningen (n = 235). HR-QOL, evaluated Short Form-36 questionnaire (SF-36) an questionnaire. Results compared population data (matched for sex age). Demographical clinical associated assessed.Response rate was 83%. scored lower on HR-QOL than population. sSS...
<b>Background:</b> Salivary gland dysfunction is one of the key manifestations Sjögren's syndrome. <b>Objectives:</b> (1) To assess prospectively loss function individual salivary glands in patients with primary and secondary syndrome relation to disease duration use immunomodulatory drugs. (2) study changes sialochemical laboratory values subjective complaints over time. <b>Methods:</b> 60 were included this study. Whole gland-specific saliva (parotid submandibular/sublingual (SM/SL)),...
Abstract Objective To assess the effect of rituximab (anti‐CD20 antibody) therapy on (immuno)histopathology parotid tissue in patients with primary Sjögren's syndrome (SS) and correlation histologic findings flow rate composition saliva. Methods In a phase II study, an incisional biopsy specimen was obtained from 5 SS before 12 weeks after treatment (4 infusions 375 mg/m 2 ). The relative amount parenchyma, lymphocytic infiltrate, fat, presence/quantity germinal centers lymphoepithelial duct...