A5029918292- Celiac Disease Research and Management
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Microscopic Colitis
- Venous Thromboembolism Diagnosis and Management
- Eosinophilic Esophagitis
- Alcohol Consumption and Health Effects
- Colorectal Cancer Screening and Detection
- COVID-19 Clinical Research Studies
- Blood Coagulation and Thrombosis Mechanisms
- Liver Diseases and Immunity
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Diverticular Disease and Complications
- Esophageal and GI Pathology
- Appendicitis Diagnosis and Management
- Autoimmune and Inflammatory Disorders Research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Parvovirus B19 Infection Studies
- Central Venous Catheters and Hemodialysis
- Acute Myocardial Infarction Research
University of Nottingham
2016-2025
East Midlands Academic Health Science Network
2021-2025
Nottingham University Hospitals NHS Trust
2014-2025
Nottingham Biomedical Research Centre
2016-2025
Queen's Medical Centre
2011-2025
National Institute for Health Research
2013-2025
Aarhus University
2022-2025
Aarhus University Hospital
2024-2025
Brain and Cognition Discovery Foundation
2024
Nottingham City Hospital
2013-2023
<b>Objective</b> To determine the incidence of and mortality from bullous pemphigoid pemphigus vulgaris in United Kingdom. <b>Design</b> Retrospective historical cohort study. <b>Setting</b> Computerised medical records health improvement network, a large population based UK general practice database. <b>Participants</b> Patients with diagnostic codes age, sex, matched controls. <b>Main outcome measures</b> Incidence compared control by calendar period, age group, geographical region, degree...
Idiopathic pulmonary fibrosis (IPF) and sarcoidosis are common diagnoses in patients attending chest clinics, but little is known about the epidemiology of these diseases. We used data from a general practice database to provide information on current incidence IPF UK.Data were extracted for all with diagnosis or between 1991 2003. The whole population was calculate disease stratified by age, sex, region, time period. Poisson regression compare populations Cox survival populations.920 cases...
<b>Objective:</b> To examine the seroprevalence, correlates, and characteristics of undetected coeliac disease in a large adult population sample Cambridge, UK. <b>Methods:</b> The Cambridge General Practice Health Study invited individuals from 12 general practices, aged 45–76 years, to attend for health survey that included bone density measurement, between 1990 1995. A total 7550 participants’ serum samples were tested antiendomysial antibody (EMA). Seroprevalence was based on EMA...
<h3>Background</h3> Previous studies have shown that the incidence of idiopathic pulmonary fibrosis (IPF) is rising in UK and USA. Death registrations primary care data were used to determine current trends IPF UK. Because routine clinical sets used, term syndrome (IPF-CS) describe individuals this study. <h3>Methods</h3> Age- stratum-specific death registration rates between 1968 2008 calculated these applied population generate annual standardised expected number deaths. Annual mortality...
<h3>Abstract</h3> <b>Objective</b> To quantify the risks of malignancy and mortality in people with coeliac disease compared general population. <b>Design</b> Population based cohort study. <b>Setting</b> General practice research database. <b>Participants</b> 4732 23 620 matched controls. <b>Main outcome measures</b> Hazard ratios for mortality. <b>Results</b> Of disease, 134 (2.8%) had at least one 237 (5.0%) died. The overall hazard were: any 1.29 (95% confidence interval 1.06 to 1.55),...
Few studies have quantified the incidence and prevalence of celiac disease (CD) dermatitis herpetiformis (DH) nationally regionally by time age groups. Understanding this epidemiology is crucial for hypothesizing about causes quantifying burden disease.Patients with CD or DH were identified in Clinical Practice Research Datalink between 1990 2011. Incidence rates calculated age, sex, year, region residence. rate ratios (IRR) adjusted Poisson regression.A total 9,087 incident cases 809...
Summary Knowledge of the absolute and relative risk venous thromboembolism (VTE) in around pregnancy would be crucial identifying when to commence cease thromboprophylaxis women who benefit from such intervention. We addressed this hypothesis using a large prospective primary care database United Kingdom, containing details on 972 683 aged 15–44 years between 1987 2004. Risks first VTE during antepartum, postpartum outside were compared Poisson regression. The rate third trimester antepartum...
In the last two decades, mortality from primary liver cancer has increased in UK. We aimed to determine whether incidence trends for these cancers were similar and particular if increasing occurrence of cholangiocarcinoma continued. calculated directly age-standardised rates (using European standard population) by subsite histological type all liver, gallbladder biliary tract England Wales 1971 2001, using registry data. The increased, with greatest rise, around 12-fold, intrahepatic bile...
Abstract Background: Mortality due to cirrhosis has tripled over the last 30 years in UK. However, we lack adequate, contemporary, population‐based estimates of excess mortality patients who are at risk compared with general population. Aim: To determine overall survival population taking into account effects severity and aetiology disease comorbidity. Methods: In a cohort study, identified 4537 people control 44 403 patients, matched by age, sex practice from UK General Practice Research...
OBJECTIVES: Azathioprine is an accepted treatment of inflammatory bowel disease (IBD), but concerns exist regarding its carcinogenic potential. Studies in renal transplant and rheumatology patients have reported increased cancer risk. In IBD, studies suggest a small risk lymphoma protection against colorectal cancer, the overall malignancy has not been established. METHODS: We conducted nested case–control study using General Practice Research Database. Records IBD were examined for...
Aliment Pharmacol Ther 2010; 32: 1343–1350 Summary Background We lack population‐based estimates of the rate decompensation in people with compensated cirrhosis as well manner which disease progresses once identified. Aim To determine and clinical progression patients based upon symptoms recorded electronically general practice data. Methods Using Cox proportional hazards regression, we modelled for from UK General Practice Research Database a diagnosis between 1987 2002. determined first...
<h3>Objective</h3> To determine the risk of diverticular perforation associated with current and ever use corticosteroids, opiate analgesics, non-steroidal anti-inflammatory drugs, aspirin, cyclo-oxygenase-2 inhibitors, statins calcium antagonists. <h3>Design, setting participants</h3> Case–control analysis using conditional logistic regression data from UK General Practice Research Database. The study involved 899 cases incident 8980 population controls 1990 to 2005. <h3>Main outcome...