A5100324576- Prostate Cancer Treatment and Research
- Endoplasmic Reticulum Stress and Disease
- Genital Health and Disease
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Cancer, Lipids, and Metabolism
- Fibroblast Growth Factor Research
- Cellular transport and secretion
- FOXO transcription factor regulation
- Calpain Protease Function and Regulation
- Cholesterol and Lipid Metabolism
- Mass Spectrometry Techniques and Applications
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Renal cell carcinoma treatment
- Calcium signaling and nucleotide metabolism
- Renal and related cancers
- Neuroscience and Neuropharmacology Research
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
- Neurological Disease Mechanisms and Treatments
- Hippo pathway signaling and YAP/TAZ
- Cytokine Signaling Pathways and Interactions
- Urologic and reproductive health conditions
- Kruppel-like factors research
Tongji Hospital
2018-2024
Huazhong University of Science and Technology
2016-2024
First Affiliated Hospital of Zhengzhou University
2024
Union Hospital
2022
University of Science and Technology of China
2020
The Hippo‑yes‑associated protein (YAP) signaling pathway was previously identified to serve an important role in controlling chondrocyte differentiation and post‑natal growth. Growth plate cartilage tissue is avascular, hypoxia‑inducible factor (HIF)‑1α essential for chondrocytes maintain their chondrogenic phenotype a hypoxic environment. In the present study, of hypoxia HIF‑1α regulation YAP investigated. data demonstrated that promoted maintenance phenotype, expression activation...
Glioblastoma multiforme (GBM) almost invariably acquires an invasive phenotype, resulting in limited therapeutic options. Protein palmitoylation markedly affects tumorigenesis and malignant progression GBM. The role of protein GBM, however, has not been systematically reported. This study aimed to investigate the effect on GBM cell survival cycle. In this study, most palmitoyltransferases were upregulated its lines, participated signaling pathways controlling Inhibition with substrate-analog...
Osteosarcoma is a primary malignant tumor originating from mesenchymal tissue, with poor distant metastasis prognosis. The molecular mechanisms of osteosarcoma are extremely complicated.A public data series (GSE21257) was used to identify differentially expressed genes (DEGs) in patients that did, or did not, develop metastases. Functional enrichment analysis, protein-protein interaction network, and survival analysis DEGs were performed. prognostic value considered as candidate their...
ATP6V1s participate in the biological process of transporting hydrogen ions and are associated with various cancers expression clinicopathological features, while its role kidney renal clear cell carcinoma is unknown. We aimed to demonstrate relationship between carcinoma. This study investigated roles KIRC using Oncomine, The Cancer Genome Atlas, UALCAN, Human Protein Clinical Proteomics Tumor Analysis Consortium, GeneMANIA, IMmune Estimation Resource, GEPIA databases. Low mRNA protein...
Background: Ubiquitin and ubiquitin-like (UB/UBL) conjugations are one of the most important post-translational modifications involve in occurrence cancers. However, biological function clinical significance ubiquitin related genes (URGs) prostate cancer (PCa) still unclear. Methods: The transcriptome data clinicopathological were downloaded from Cancer Genome Atlas (TCGA), which was served as training cohort. GSE21034 dataset used to validate. two datasets removed batch effects normalized...
Sharply increased reactive oxygen species (ROS) are thought to induce oxidative stress, damage cell structure and cause death; however, its role in prostate cancer remains unclear. Enzalutamide is a widely used anti-prostate drug that antagonizes androgen binding with receptor. Further exploration of the mechanism potential application strategies enzalutamide crucial for treatment cancer. Here, we confirmed PEX10 can be induced by ROS activators while reduce level cells, which weakened...
Cisplatin is a widely used chemotherapeutic agent. However, its clinical application remains limited due to the high incidence of severe ototoxicity. It has been reported that unfolded protein response (UPR) involved in cisplatin-induced specific mechanism underlying effect unclear. Therefore, present study aimed explore sequential changes key UPR signaling branch and potential pro-apoptotic role The hair cell-like OC-1 cells were treated with cisplatin for different periods then expression...
Prostate cancer is the third leading cause of new cases and second most common tumor type in men globally. LMO3 has been stated to play a vital role some cancers; however, prognostic value PCa remains vague. Here, we utilized various web databases elucidate detail molecular functions PCa. expression was significantly decreased Low associated with gender, age, TNM grade predicted poor prognosis patients. Functional enrichment analysis suggested that engaged extracellular matrix immune...
<title>Abstract</title> <bold>Background:</bold> Osteosarcoma is an aggressive malignancy of bone that poses significant treatment challenges and has been a focal point extensive research due to its complex pathogenesis. Despite advances in traditional therapeutic approaches, the intricate genetic cellular landscape osteosarcoma remains inadequately understood, emphasizing need for innovative methodologies unravel underlying mechanisms. <bold>Objective:</bold> This study aims leverage power...
Negative lymph nodes status has been attached more attention as a prognostic indicator for nonmetastatic penile cancer. We aimed to identify the appropriate number of negative dissection cancer using Surveillance, Epidemiology and End Results database. A total 1,470 patients with squamous cell carcinoma were identified during 2004 2013. All categorised according different risk levels lymphadenectomy. Univariate multivariate Cox regression analyses performed evaluate relationship between...
Osteosarcoma is one of the most common types bone sarcoma with a poor prognosis. However, genes involved in mineral metabolism microenvironment affected by osteosarcoma are, to date, largely unknown. A public data series (GSE114237) was used identify differentially expressed (DEGs) between cells adhering demineralized osseous surfaces and mineralized surfaces. Functional enrichment analysis DEGs hub genes, protein-protein interaction network regulatory (miRNA-mRNA transcription factor...
Stroke, a major cause of morbidity and mortality, affects mil-lions lives worldwide every year. DAPK1 has multiple roles is linked to several cell death-related signaling pathways in ischemia. DAPK1-NR2B, DAPK1-DANGER, DAPK1-p53, DAPK1-Tau are currently known stroke- induced death, we block these cascades an acute treatment see whether it will reduce damage. Block interaction can effectively neuronal loss.