A5101751853- Crystallization and Solubility Studies
- Covalent Organic Framework Applications
- X-ray Diffraction in Crystallography
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Photocatalysis Techniques
- Luminescence and Fluorescent Materials
- Immune Cell Function and Interaction
- Catalytic C–H Functionalization Methods
- T-cell and B-cell Immunology
- Asymmetric Synthesis and Catalysis
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Synthesis and Properties of Aromatic Compounds
- Immunotherapy and Immune Responses
- Cancer, Lipids, and Metabolism
- Synthesis and Catalytic Reactions
- Supramolecular Self-Assembly in Materials
- Synthetic Organic Chemistry Methods
- Caching and Content Delivery
- Prostate Cancer Treatment and Research
- Viral-associated cancers and disorders
- Hematopoietic Stem Cell Transplantation
- Mast cells and histamine
- Histone Deacetylase Inhibitors Research
National University of Singapore
2017-2025
Peking University People's Hospital
2020-2025
Peking University
2020-2025
First Affiliated Hospital of Zhengzhou University
2020-2024
Zhengzhou University
2024
Tsinghua University
2022
Qilu Normal University
2022
Abstract We report herein the first enantioselective cycloaddition of vinyl oxetanes, reaction which with azadienes provided unprecedented access to ten‐membered heterocycles through a [6+4] cycloaddition. By using commercially available chiral Pd‐SIPHOX catalyst, wide range benzofuran‐ as well indole‐fused could be accessed in excellent yield and enantioselectivity. A unique Lewis acid induced fragmentation these was also discovered.
The development of efficient photocatalysts for N2 fixation to produce NH3 under ambient conditions remains a great challenge. Since covalent organic frameworks (COFs) possess predesignable chemical structures, good crystallinity, and high porosity, it is highly significant explore their potential photocatalytic nitrogen conversion. Herein, we report series isostructural porphyrin-based COFs loaded with Au single atoms (COFX-Au, X = 1-5) fixation. porphyrin building blocks act as the docking...
Attempts to develop photocatalysts for hydrogen production from water usually result in low efficiency. Here we report the finding of by integrated interfacial design stable covalent organic frameworks. We predesigned and constructed different molecular interfaces fabricating ordered or amorphous π skeletons, installing ligating non-ligating walls engineering hydrophobic hydrophilic pores. This systematic control over electron transfer, active site immobilisation transport enables identify...
Covalent organic frameworks (COFs) provide a molecular platform for designing novel class of functional materials with well-defined structures. A crucial structural parameter is the linkage, which dictates how knot and linker units are connected to form two-dimensional polymers layer frameworks, shaping ordered π-array porous architectures. However, roles linkage in development π electronic structures functions remain fundamental yet unresolved issues. Here we report designed synthesis COFs...
Abstract Covalent organic frameworks are a novel class of crystalline porous polymers that enable molecular design extended polygonal skeletons to attain well‐defined structures. However, construction framework allows remote control pores remains challenge. Here we report strategy merges covalent, noncovalent, and photo chemistries photoresponsive with reversibly remotely controllable pores. We developed topology‐guided multicomponent polycondensation system integrates protruded...
Reported herein is the divergent syntheses of [5,5] and [6,5] spiro-heterocycles under Lewis-acid-assisted palladium catalysis. In particular, an unprecedented switch from alkoxide-π-allyl to dienolate reactivity was achieved by use palladium-titanium relay catalysis, represents umpolung vinylethylene carbonates. This method uses a simple procedure commercially available catalysts, delivers both classes spiro-heterocycles, bearing three contiguous stereocenters, in high yield uniformly...
The development of chiral covalentorganic framework catalysts (CCOFs) to synthesize enantiopure organic compounds is crucial and highly desirable in synthetic chemistry. Photocatalytic asymmetric reactions based on CCOFs are eco-friendly sustainable while they still elaborate. In this work, we report a general bottom-up strategy successfully several photoactive CCOFX (X = 1-5 1-Boc). porphyrin building blocks selected as knots various secondary-amine-based catalytic centers immobilized the...
Abstract Die Fortschritte der Chemie im letzten Jahrzehnt ebnen neue Wege zur Gestaltung organischer Polymere über Topologiediagramme. Dieser Ansatz ermöglicht das kovalente Zusammenfügen Einheiten zu geordneten Topologien einer neuen Polymerform, den kovalenten organischen Gerüstverbindungen. Dies bedeutet einen Durchbruch in Chemie, da nunmehr eine molekulare Plattform für die Synthese von Polymeren mit vorbestimmbaren Primärstrukturen und Strukturen höherer Ordnung Verfügung steht, ein...
Abstract We report herein the first enantioselective cycloaddition of vinyl oxetanes, reaction which with azadienes provided unprecedented access to ten‐membered heterocycles through a [6+4] cycloaddition. By using commercially available chiral Pd‐SIPHOX catalyst, wide range benzofuran‐ as well indole‐fused could be accessed in excellent yield and enantioselectivity. A unique Lewis acid induced fragmentation these was also discovered.
Abstract Amine oxidase copper-containing 1 ( AOC1 ) is considered an oncogene in many types of tumors. Nevertheless, there have been no investigations and its regulatory mechanism prostate cancer. Here, we reveal a novel action tumor suppressor downregulated Abatement cancer tissue positively correlated with the size, lymph node metastasis, Gleason score for Conversely, high expression significantly associated reduced proliferation migration both vitro vivo. We show that anticancer effect...
Covalent organic frameworks, as a class of fascinating crystalline porous materials, are attracting increasing attention in various fields. Synthesizing these materials to attain crystallinity and porosity is essential; however, it time-consuming, not cost-effective, energy-demanding involves extensive screenings reaction conditions employs undesired aromatic solvents. Despite recent progress the synthesis, finding an efficient, convenient, low-toxicity, widely applicable method remains...
Abstract Covalent organic frameworks (COFs) provide a molecular platform for designing novel class of functional materials with well‐defined structures. A crucial structural parameter is the linkage, which dictates how knot and linker units are connected to form two‐dimensional polymers layer frameworks, shaping ordered π‐array porous architectures. However, roles linkage in development π electronic structures functions remain fundamental yet unresolved issues. Here we report designed...
Covalent organic frameworks (COFs) create extended two-dimensional (2D) skeletons and aligned one-dimensional (1D) channels, constituting a class of novel π architectures with predesignable structural ordering. A distinct feature is that stacks building units in shape the pore walls, onto which diversity different can be assembled to form various interfaces, opening great potential trigger strong correlation between skeleton pore. However, such possibility has not yet been explored. Herein,...
Abstract Helicenes are a class of fascinating chiral helical molecules with rich chemistry developed continuously over the past 100 years. Their helical, conjugated, and twisted structures make them attractive for constructing molecular systems. However, studies century mainly focused on synthesizing helicenes increased numbers aromatic rings complex heterostructures, while research inorganic, organic, polymeric helicene materials is still embryonic. Herein, we report first examples covalent...
Heat shock protein family B [small] member 6 (HSPB6), widely found in various muscles, has been recently identified as a tumor suppressor gene. However, its role prostate cancer remains unexplored. Herein, we investigated the expression of HSPB6 and association with prognosis. Our findings revealed that downregulation correlated poor Moreover, discovered can be phosphorylated activated by 8-Br-cGMP, leading to apoptosis cells activating Cofilin. Additionally, demonstrated knocking down E2F1...
Abstract Reported herein is the divergent syntheses of [5,5] and [6,5] spiro‐heterocycles under Lewis‐acid‐assisted palladium catalysis. In particular, an unprecedented switch from alkoxide‐π‐allyl to dienolate reactivity was achieved by use palladium‐titanium relay catalysis, represents umpolung vinylethylene carbonates. This method uses a simple procedure commercially available catalysts, delivers both classes spiro‐heterocycles, bearing three contiguous stereocenters, in high yield...