A5101454242- Pulsars and Gravitational Waves Research
- Astrophysical Phenomena and Observations
- Galaxies: Formation, Evolution, Phenomena
- Lung Cancer Treatments and Mutations
- Geophysics and Sensor Technology
- Astronomical Observations and Instrumentation
- Astrophysics and Star Formation Studies
- Lung Cancer Research Studies
- Gamma-ray bursts and supernovae
- Astronomy and Astrophysical Research
- Stellar, planetary, and galactic studies
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Radio Astronomy Observations and Technology
- Geophysics and Gravity Measurements
- Hepatitis B Virus Studies
- Astrophysics and Cosmic Phenomena
- High-pressure geophysics and materials
- CAR-T cell therapy research
- Lung Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Clinical Laboratory Practices and Quality Control
- Cancer therapeutics and mechanisms
- Pharmacogenetics and Drug Metabolism
Chinese Academy of Medical Sciences & Peking Union Medical College
1996-2025
Peking Union Medical College Hospital
2012-2025
Chinese Academy of Sciences
2011-2024
Xinjiang Astronomical Observatory
2011-2024
Xiyuan Hospital
2024
National Astronomical Observatories
2024
National Clinical Research
2019
University of Chinese Academy of Sciences
2011-2015
We discuss applications of the study new and barely explored class changing-look (CL) narrow-line Seyfert 1 (NLS1) galaxies comment on their detection with space mission SVOM (Space Variable Objects Monitor). highlight case NGC 1566, which is outstanding in many respects, for instance as one nearest known CL AGN undergoing exceptional outbursts. Its NLS1 nature discussed, we take it a nearby prototype systems that could be discovered studied near future, including SVOM. Finally, briefly...
Combretastatin A4 phosphate (CA4P) is a prodrug that selectively destroys tumor blood vessels, and has shown efficacy as targeted anticancer drug in both animal models clinical trials. The aims of this single-center, open label, phase I trial were to investigate the safety tolerability CA4P administered intravenously patients aged 18-65 years with advanced solid tumors. Using dose-escalation protocol, assigned five groups received injections 20 (n=3), 33 50 (n=11), 65 (n=6), or 85 (n=2)...
Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous malignancy with diverse patient outcomes, largely influenced by the tumor microenvironment (TME). Understanding roles of fibroblasts and macrophages within TME essential for developing personalized therapeutic strategies in DLBCL. This study multi-omics approach, integrating spatial transcriptomics (n = 11), bulk 2,499), immunohistochemistry (IHC, n 37), multiplex immunofluorescence (mIF, 56), plasma samples 240) to identify...
view Abstract Citations (77) References (25) Co-Reads Similar Papers Volume Content Graphics Metrics Export Citation NASA/ADS Radio Observations of the 1989 Transient Event in V404 Cygni (= GS 2023+338) Han, Xiaohong ; Hjellming, R. M. bright transient X-ray source 2023+338 conducted between May 30, and 31, 1991 with VLA at 1.49, 4.9, 8.4, 14.9 GHz are reported. The radio spectrum evolved from an optically thin synchrotron during first 2 d to flat then 'inverted', a strong overall tendency...
Abstract Objective: This phase I study was to evaluate safety, maximum tolerated dose, pharmacokinetics and preliminary antitumor activity of chidamide, a novel subtype-selective histone deacetylase (HDAC) inhibitor, in combination with paclitaxel carboplatin patients advanced non-small cell lung cancer (NSCLC). Methods: Ten received oral chidamide 20, 25, or 30 mg twice per week continuously (175 mg/m2) [area under the curve (AUC) 5 mg/mL/min] administered 3-week cycle. Patients response...
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The incidence and mortality of thyroid cancer are on the increase worldwide treatment options for progressive, radioactive iodine (RAI)-refractory metastatic differentiated (DTC) patients currently limited. Sorafenib is a multikinase inhibitor that targets several molecular signals, which believed to be involved in pathogenesis DTC. In this study, we reported our experience with off-label use sorafenib Chinese patients. A total 8 (7 papillary 1 follicular cancer) were recruited study....
Context. CN, HCN, and HNC have been used to discuss the star formation sequence in galaxies, but recent studies of large samples involving these lines did not yet provide convincing results.
Abstract We report two phenomena detected in PSR J0344−0901 from observations conducted at frequencies centered 1.25 GHz using the Five-hundred-meter Aperture Spherical Radio Telescope. The first phenomenon manifests as pulse emission shifting to later longitudinal phases and then gradually returning its original location. event lasts for about 216 periods, with an average shift of 0.°7 measured peak integrated profile. Changes polarization position angle (PPA) are around trailing edge...
Context. Accurate distances are necessary for determining the physical properties of massive star-formation regions and structure our Galaxy. One way to approach these studies is by kinematic H ii regions.
Background To establish and validate an laboratory information system (LIS)‐based auto‐verification (AV) by using large amounts of biochemical test results in cancer patients. Methods An algorithm the AV process was designed for pre‐analysis, analysis, post‐analysis. The limit range check adjusted three times, while delta criteria were first replaced same patients’ historical extremum results. rules 51 items tested data 121 123 samples (6 177 273 tests) 2016 that manually reviewed through...
We investigate relations in the emission properties as revealed by drifting subpulses detected at different observing frequencies based on method that incorporates rotating carousels pulsar magnetospheres of multiple states. An state is associated with particular determined a frequency, and states obtained reveal variation across region. The allows determination essential radio such relative height, subpulse number, charge density plasma flow to corotation an region for frequency. apply...
Third-generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are the latest and a vital treatment option for non-small cell lung cancer (NSCLC) patients. Although EGFR-sensitive mutations an indication third-generation EGFR-TKI therapy, 30% of NSCLC patients lack response all inevitably progress. There is biomarkers to predict efficacy therapy. In this report, we performed comprehensive plasma metabolomic profiling on 186 baseline 20 post-treatment samples,...
Chlorogenic acid (CA) is well known for its various biological activities. Here, a clinical study was performed in patients with advanced malignant cancer to explore therapeutic effects. We aimed develop method quantify CA human plasma and urine assist the pharmacokinetic study.Ultra-performance liquid chromatography (UPLC) coupled triple quadruple mass spectrometry used separate detect CA, puerarin serving as internal standard.The presents an excellent linearity ranging from 5 2000 ng/mL...
Carcinoembryonic antigen (CEA) is frequently used in the diagnosis of colorectal carcinoma. CA242 a novel unique tumor-associated characterized by higher tumor specificity and sensitivity for cancer, as compared with other mucin antigens. In this study, preoperative levels serum CEA were measured 63 cases It was disclosed that positive rate than CEA, particularly patients colon cancer. The combined determination significantly increased accuracy detection cancer use alone (P<0.01). advanced...