A5045092259- Cell death mechanisms and regulation
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Hydrology and Watershed Management Studies
- Hydrological Forecasting Using AI
- Cancer Research and Treatments
- Climate variability and models
- Microbial Natural Products and Biosynthesis
- PARP inhibition in cancer therapy
- Flood Risk Assessment and Management
- Cancer-related Molecular Pathways
- Parkinson's Disease Mechanisms and Treatments
- Alkaloids: synthesis and pharmacology
- Synthesis and Biological Activity
- Muscle Physiology and Disorders
- Phytochemistry and Bioactive Compounds
- Peptidase Inhibition and Analysis
- Drug-Induced Hepatotoxicity and Protection
- Cancer Mechanisms and Therapy
- Dialysis and Renal Disease Management
- GDF15 and Related Biomarkers
- Cancer therapeutics and mechanisms
- Magnolia and Illicium research
- Spinal Hematomas and Complications
- Nutrition and Health in Aging
Hubei University of Medicine
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2023
Yunnan University
2023
Yangzhou University
2023
Abstract Background Azithromycin is a member of macrolide antibiotics, and has been reported to inhibit the proliferation cancer cells. However, underlying mechanisms are not fully elucidated. Tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) selectively targets tumor cells without damaging healthy In present study, we examined whether azithromycin synergistic with TRAIL, if so, in colon cancers. Methods HCT‐116, SW480, SW620 DiFi were treated azithromycin, purified or their...
Raistrickindole A (1), a new indole diketopiperazine alkaloid containing an unusual pyrazino[1′,2′:2,3][1,2]oxazino[6,5-b]indole tetraheterocyclic ring system, benzodiazepine derivative, raistrickin (2), and the known haenamindole (3) sclerotigenin (4) were isolated from marine-derived fungus Penicillium raistrickii IMB17-034. Their structures elucidated by extensive spectroscopic analyses TDDFT calculations of NMR ECD data. Compounds 1 2 showed inhibitory activities against hepatitis C virus.
Cancer cachexia as a metabolic syndrome can lead to at least 25% of cancer deaths. The inhibition muscle atrophy is main strategy treat cachexia. In this process, myostatin (MSTN) exert dual effect on protein metabolism, including biosynthesis and enhancement degradation. study, we will test the induced by IMB0901, MSTN inhibitor. Two high-throughput screening models against were developed. By screening, 2-((1-(3,4-dichlorophenyl)-1H-pyrazolo [3,4-d] pyrimidin-4-yl) amino) butan-1-ol, was...
FBXO28 is a member of F-box proteins that are the substrate receptors SCF (SKP1, CULLIN1, protein) ubiquitin ligase complexes. Despite implications its role in cancer, function epithelial-mesenchymal transition (EMT) process and metastasis for cancer remains largely unknown. Here, we report critical negative regulator migration, invasion human hepatocellular carcinoma (HCC) vitro vivo. expression upregulated epithelial cell lines relative to mesenchymal counterparts. Mechanistically, by...
Tetracenomycin X (Tcm X) has been reported to have antitumour activity in various cancers, but there not any studies on its with respect lung cancer date. Therefore, this study aims investigate the anti-lung of Tcm X. In study, we found that tetracenomycin showed vivo and selectively inhibited proliferation cells without influencing fibroblasts. addition, apoptosis autophagy did contribute activity. exerts through cell cycle arrest induced by downregulation cyclin D1. To explore specific...
This study aims to investigate the factors that influence fatigue in hemodialysis (HD) patients and develop validate a nomogram estimate probability of this population.
Multisource meteorological re-analyses are the most reliable forcing data for driving hydrological models to simulate streamflow. We aimed assess different responses through modeling in upper Lancang-Mekong River Basin (LMRB) using two gridded datasets, climate forecast system reanalysis (CFSR) and China Meteorological Assimilation Driving Datasets SWAT model (CMADS). selected Pearson’s correlation coefficient (R), percent bias (PBIAS), root mean square error (RMSE) indices compare six...
Multisource meteorological re-analyses provide the most reliable forcing data for driving hydrological models to simulate streamflow. We aimed assess different responses through modeling in upper Lancang-Mekong River Basin (LMRB) using two gridded datasets, Climate Forecast System Re-analysis (CFSR) and China Meteorological Assimilation Driving Datasets Soil Water Assessment Tool (SWAT) model (CMADS). selected Pearson’s correlation coefficient (R), percent bias (PBIAS), root mean square...