A5101632533- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Intraocular Surgery and Lenses
- Retinal and Optic Conditions
- Retinal and Macular Surgery
- Cardiomyopathy and Myosin Studies
- Gout, Hyperuricemia, Uric Acid
- Ocular Diseases and Behçet’s Syndrome
- Viral Infections and Immunology Research
- Traumatic Ocular and Foreign Body Injuries
- Retinal Development and Disorders
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Fault Detection and Control Systems
- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Mycobacterium research and diagnosis
- Natural Compounds in Disease Treatment
- Facial Trauma and Fracture Management
- Biosimilars and Bioanalytical Methods
- Health Systems, Economic Evaluations, Quality of Life
- Autoimmune and Inflammatory Disorders Research
- Yersinia bacterium, plague, ectoparasites research
- Genomics, phytochemicals, and oxidative stress
Hefei University of Technology
2025
Zhejiang University of Technology
2025
Tongji Hospital
2022-2024
Huazhong University of Science and Technology
2022-2024
Peking University Third Hospital
2011-2023
Peking University
2012-2023
Jiangnan University
2023
Columbia University
2020-2021
Ministry of Education of the People's Republic of China
2015-2017
Northwest University
2017
Unrepaired cardiomyocyte membrane injury causes irreplaceable cell loss, leading to myocardial fibrosis and eventually heart failure. However, the cellular molecular mechanisms of cardiac repair are largely unknown. MG53, a newly identified striated muscle-specific protein, is involved in skeletal muscle repair. But role MG53 has not been determined.We sought investigate whether mediates cardiomyocytes and, if so, mechanism underlying MG53-mediated cardiomyocytes. Moreover, we determined...
Accumulating data suggest a link between alterations/deficiencies in cytoskeletal proteins and the progression of cardiomyopathy heart failure, although molecular basis for this remains unclear. Cypher/ZASP is protein localized sarcomeric Z-line. Mutations its encoding gene have been identified patients with isolated non-compaction left ventricular myocardium, dilated (DCM) hypertrophic cardiomyopathy. To explore role Cypher myocardium to better understand mechanisms by which mutations...
The key events in the development of US generic drug industry after Hatch-Waxman Act 1984 are systematically reviewed, including process approval for drugs, bioequivalence issues "switchability", complicated dosage forms, patent extension, safety, substitution and low-cost generics. backlog review, user fees, "quality by design" drugs is also discussed. evolution has afforded several lessons great benefit to other countries wishing establish or re-establish a domestic industry.
Abstract Controversy surrounds the role of serum uric acid and whether treatment intervention is favorable in retarding progression chronic kidney disease (CKD). The association levels CKD patient mortality risk needs to be further determined by large sample cohort studies. National Health Nutrition Examination Survey participants with from 1998 2017 were enrolled study. Multivariable Cox regression models used reveal concentrations risks. A total 9891 patients study, 3698 individuals died...
ABSTRACT This article mainly presents a fresh systematic framework to tackle the resilient fault‐tolerant sampled‐data control (SDC) synthesis problem for networked interval type‐2 fuzzy systems (IT‐2FSs) suffering with semi‐Markovian‐type jump actuator failures (SMJAFs) and mismatched membership functions (MMFs), which portrays more features than some prior developments. The principally target of addressed under this investigation is precisely architect faulty mode‐dependent controller such...
Inspired by natural quinoline, a series of novel quinoline derivatives containing thioether groups were designed and synthesized. All target compounds characterized using 1H NMR, 13C HRMS. Their antifungal activities evaluated in vitro against ten phytopathogenic fungi. Among the synthesized compounds, 3l (4‐(allylthio)‐8‐fluoro‐2,3‐dimethylquinoline) exhibited significant activity, with inhibition rates exceeding 80% Sclerotinia sclerotiorum Physalospora piricola at 50 μg/mL. The...
purpose. To evaluate a surgical procedure for patients with hemorrhagic age-related macular degeneration (AMD). methods. This consisted of excision the choroidal neovascular membrane and transplantation autologous retinal pigment epithelium (RPE)–Bruch's complex. The RPE–Bruch's complex was surgically developed by dissecting Bruch's choriocapillaris from medium size vessel layer at midperipheral region choroid. Twenty-one eyes 21 had this procedure. Visual function tests included best...
To report the results and complications of scleral buckling for treatment rhegmatogenous retinal detachment (RRD) using 25-gauge chandelier endoillumination.A total 61 patients (61 eyes) with RRD were treated buckling. For sclera procedure, a was inserted through pars plana intra-ocular illumination, tears identified episcleral cryotherapy under surgical microscope. On postoperative days 1, 3 7, pressure measured by non-contact tonometer. months 1 3, ultrasound biomicroscopy used to examine...
Abstract Tenascin‐c is an extracellular matrix glycoprotein, the expression of which relates to progression atherosclerosis, myocardial infarction and heart failure. Annexin II acts as a cell surface receptor tenascin‐c. This study aimed delineate role tenascin‐c annexin in macrophages presented atherosclerotic plaque. Animal models with lesions were established using ApoE‐ KO mice fed high‐cholesterol diet. The was determined by qRT ‐ PCR , Western blot immunohistochemistry analysis. Raw...
This study aimed to investigate the effects of triptolide (TP) on collagen-induced arthritis (CIA) mice and related mechanisms.CIA were administered TP for 35 days. Mouse ankle joints serum antibodies cytokines examined assess therapeutic TP. The ratios Treg, Th1 Th17 cells measured by flow cytometry RT-qPCR. Reverse docking was used characterize binding modes against target proteins. expression STAT3 pathway in CIA evaluated western blotting immunofluorescence staining. spleen lymphocytes...
The present study aimed to identify the genetic mutations in two families affected with congenital cataracts. Detailed family histories and clinical data of members were recorded. phenotypes recruited, candidate gene sequencing was performed determine disease‑causing mutation. Bioinformatics analysis predict function mutant gene. Green fluorescent protein‑tagged human wild‑type CRYAA GJA8 sub‑cloned, mutants generated by site‑directed mutagenesis. A novel mutation, c.416T>C (p.L139P), a...
Purpose.: To evaluate the long-term outcome of autologous simple RPE sheet transplantation in patients with simultaneous massive submacular hemorrhage and pigment epithelium detachment (PED). Methods.: Fourteen 10 occult AMD eyes 4 PCV underwent a surgical procedure including 180° peripheral temporal retinotomy, choroidal neovascular membrane (CNVM) excision, an developed from PED region outside CNVM lesion. Best-corrected visual acuity, multifocal ERG, microperimetry were recorded to...
Abstract Purpose To compare the outcome after choroidal neovascular ( CNV ) membrane excision and retinal pigment epithelium RPE transplantation make further evaluation of two types grafts on visual function in patients with age‐related macular degeneration AMD ), complicated by massive subretinal haemorrhage. Methods We retrospectively reviewed 80 who underwent or without transplantation. Two were adopted, –Bruch's complex graft (subgroup 1) monolayer sheet 2). Outcome measures included...
Purpose: We correlated quantitative fundus autofluorescence (qAF) with other features in patients exhibiting central serous chorioretinopathy (CSC). Methods: Short wavelength (SW-AF, 488 nm excitation) was measured by qAF. Using nonnormalized images qAF values were calculated within eight concentric segments (qAF8) located at an eccentricity of 7° to 9°. Horizontal spectral domain optical coherence tomography (SD-OCT) scans and near-infrared (NIR-AF) studied. Results: Thirty-six eyes 20...
Purpose: The purpose of this study was to compare the efficacy intravitreal bevacizumab (IVB) in treatment acute (<3 months [mo]. duration) macular edema (ME), with or without subretinal hemorrhage (SRH), resulting from branch retinal vein occlusion (BRVO).Materials and methods: We conducted a retrospective review 33 consecutive patients (n = eyes) ME caused by BRVO. All received an injection IVB at baseline examination. were followed monthly, administration additional injections if there...
Skin cutaneous melanoma (SKCM) is one of the most aggressive and life-threatening tumors. It has a high incidence rate, as well significant metastasis fatality rates. To successfully treat SKCM to increase overall survival early identification risk stratification are both absolutely necessary. Long noncoding RNAs (lncRNAs) play regulatory role in variety cancers. However, expression function many lncRNAs have not been investigated. We evaluated profile long RNA LINC02249 (LINC02249)...