A5101424204- Cancer-related molecular mechanisms research
- Acute Myeloid Leukemia Research
- Landslides and related hazards
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Rock Mechanics and Modeling
- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- Circular RNAs in diseases
- Hemoglobinopathies and Related Disorders
- RNA modifications and cancer
- Heart Failure Treatment and Management
- MicroRNA in disease regulation
- Blood Coagulation and Thrombosis Mechanisms
- Signaling Pathways in Disease
- Geotechnical and Geomechanical Engineering
- Precipitation Measurement and Analysis
- Metal Extraction and Bioleaching
- Ferroptosis and cancer prognosis
- Seismic Imaging and Inversion Techniques
- Aortic Disease and Treatment Approaches
- Climate change and permafrost
- Extraction and Separation Processes
- Chronic Myeloid Leukemia Treatments
- Protein Kinase Regulation and GTPase Signaling
- Protein Degradation and Inhibitors
Jilin Weather Modification Office
2024
Wuhan University of Science and Technology
2024
Central South University
2014-2021
Xiangya Hospital Central South University
2017-2021
PharmacoGenetics (China)
2021
China University of Geosciences
2020
Haikou City People's Hospital
2016-2018
Second Xiangya Hospital of Central South University
2014
Xiangtan University
2010
Background/Aims: In the current study, we performed an integrated analysis of genome-wide methylation and gene expression data to find novel prognostic genes for lower-grade gliomas (LGGs). Methods: First, TCGA were used identify associated with promoter methylation. Second, candidate that stably regulated by explored. Third, Cox proportional hazards regression was generate a signature, signature construct survival risk score system. Results: Three (EMP3, GSX2 EMILIN3) selected as genes....
Diffuse gliomas are well known malignant brain tumors. Long non-coding RNAs (lncRNAs), a type of RNA transcript with more than 200 nucleotides, involve in tumorigenesis and development various cancers. This study focused on identifying differentially expressed lncRNAs based gene expression profiling, chose certain PVT1, CYTOR, HAR1A MIAT, which changed significant differences. Further analysis TCGA GEO data revealed that the expressions PVT1 CYTOR were up-regulated, while MIAT down-regulated...
Whether long non-coding RNA (lncRNA) single-nucleotide polymorphisms (SNPs) affect prognosis of acute myeloid leukemia (AML) remains unknown. To search the association between lncRNA SNPs and AML outcomes, thirty tagSNPs in five lncRNAs were genotyped 313 patients. Survival analysis indicated that GAS5 rs55829688 (T > C) was significantly associated with (p = 0.018). Patients CC genotype showed higher expression peripheral blood mononuclear cells (PBMCs) 0.025) harbored a longer platelets...
Percardiac device closure of ventricular septal defects (VSDs) is considered as an alternative to surgical repair in certain patients; however, the safety and validity this technique subaortic VSD are unproven.A total 463 patients with underwent two different operative procedures. The clinical data were collected a retrospective analysis was performed.A 145 (90.06%) cases successfully occluded Group A, 16 (9.94%) converted open-heart surgery after occlusion procedure failure. A 302 B...
Colorectal cancer is a malignant tumor which harmed human beings' health. The aim of this study was to explore common biomarkers associated with colorectal carcinogenesis in paired and noncancer samples. At first, fifty-nine pairs samples from three gene expression datasets were collected analyzed. Then, 181 upregulation 282 downregulation differential genes (DEGs) found. Next, functional annotation performed the DAVID database DEGs. Finally, real-time polymerase chain reaction (PCR) assay...
Acute myeloid leukemia (AML) is a heterogeneous clonal disease and patients with AML who harbor an FMS-like tyrosine kinase 3 (FLT3) mutation present several dilemmas for the clinician. This study aims to identify novel targets explaining dilemmas.We analyzed four microarray gene expression profiles investigate changes in whole genome associated FLT3-ITD mutation.We identified 22 differentially expressed genes which are commonly among all profiles. Kaplan-Meier analysis of dataset GSE12417...
// Xiao-Qing Yuan 1, 2 , Dao-Yu Zhang Han Yan Yong-Long Yang 3 Ke-Wei Zhu Yan-Hong Chen Xi Li Ji-Ye Yin Xiao-Lin 4 Hui Zeng Xiao-Ping 2, 5 1 Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China Institute Hunan Key Laboratory Pharmacogenetics, 410078, Pharmacy, Haikou People's Hospital and Affiliated Medical School, 570311, Hematology, Province Cooperation Innovation Center for Molecular Target New Drug Study, Hengyang 421001,...
A convective cell storm containing two differential reflectivity (ZDR) columns was observed with a dual-polarization phased-array radar (X-PAR) in Xixian County. Since ZDR column is believed to correspond strong updraft and single considered have simple dynamic structure one core, how these form coexist the focus of this study. The microphysical structures around are studied under mutual confirmation X-PAR observations cloud model simulation. main forms maintains an whose bottom corresponds...
Lower-grade gliomas (LGGs) is characteristic with great difference in prognosis. Due to limited prognostic biomarkers, it urgent identify more molecular markers provide a objective and accurate tumor classification system for LGGs.In the current study, we performed an integrated analysis of gene expression data genome-wide methylation determine novel genes sites LGGs.To that differentially expressed between 44 short-term survivors (<2 years) 48 long-term (≥2 years), searched LGGs TCGA...
Left ventricular remodeling is an essential risk factor contributing to the pathogenesis of chronic heart failure (CHF). Basigin (BSG) promotes cardiovascular inflammation and myocardial processes by induction extracellular matrix metalloproteinases inflammatory cytokines. BSG rs8259 polymorphism was associated with expression acute coronary syndrome. Therefore, we investigated whether contributes prognosis CHF in Chinese patients. In total 922 adult patients 1107 matched healthy controls...
// Mu-Peng Li 1, 2 , Yan-Jiao Zhang Xiao-Lei Hu Ji-Peng Zhou Yong-Long Yang 3 Li-Ming Peng 4 Hong Qi Tian-Lun and Xiao-Ping Chen 1 Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, P. R. China Institute Hunan Key Laboratory Pharmacogenetics, 410078, Haikou People’s Hospital Affiliated Medical School, 570311, Hainan, Cardiovascular Medicine, Correspondence to: Chen, email: chenxp74@hotmail.com Keywords: CKIP-1, polymorphism, cardiac...
In today's industrial production, there is an increasing demand for on-line monitoring of trace water. To break the low limit (a few ppm level, or even ppb) water real-time online technology, experiments and related theories prove that it possible to reduce influence temperature on electrolysis cell, ensure high precision current, finally realize measurement this paper, based basic PID control algorithm, combined with adaptive control, digital fuzzy neural network theory improve original...
Reservoir parameter estimation is one of the goals amplitude-versus-angle (AVA) inversion and angle-domain common image gathers are basis AVA inversion. Therefore, accuracy kinematic kinetic information on angle very important for reservoir characterization. Reverse time migration most physically accurate method. Generating from reverse with Poynting vector method efficient. However, due to inaccurate measurement uneven illumination, calculated by often not suitable In this paper, we propose...
Particulate matter emission has been widely concerned all over the world. The formation of condensable particulate (CPM) was affected by atmospheric temperature. An optimal-designed sampling device and monitoring method for in high-humidity flue gas were applied to concentration 12 ultra-low coal-fired units. levels composition characteristics main inorganic ions analyzed evaluated. results showed that filterable (FPM) range 0.81~7.52 mg/m 3 , 1.10~12.25 . effects different air pollution...