A5084421851- Polymer Surface Interaction Studies
- biodegradable polymer synthesis and properties
- Surgical Sutures and Adhesives
- Microplastics and Plastic Pollution
- Silk-based biomaterials and applications
- Additive Manufacturing and 3D Printing Technologies
- Biochemical and Structural Characterization
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Bone Tissue Engineering Materials
- Advancements in Transdermal Drug Delivery
- Advanced Cellulose Research Studies
- Connective tissue disorders research
- Vascular Anomalies and Treatments
- Advanced Materials and Mechanics
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Surface Modification and Superhydrophobicity
- Polyomavirus and related diseases
- Bladder and Urothelial Cancer Treatments
- Adhesion, Friction, and Surface Interactions
- Hemostasis and retained surgical items
Changchun Institute of Applied Chemistry
2022-2023
Chinese Academy of Sciences
2022-2023
Union Hospital
2022
Jilin University
2022
Tsinghua University
2022
Melanoma is the most lethal malignancy in skin cancer and may occur at any site express melanocytes. Due to malignant melanoma's invasion migration nature, conventional therapies make it challenging remove whole tumor tissue while undertaking high risks of recurrence. Regarding emerging targeted immunotherapy, drug resistance low immunotherapeutic activity remain significant challenges. It thus becoming urgently important develop alternative strategies for melanoma therapy. Herein, a novel...
Degradable bioplastics have attracted growing interest worldwide. However, it is challenging to develop with a simple processing procedure, strong mechanical performance, good biocompatibility, and adjustable physicochemical properties. Herein, we introduced structural proteins as building blocks developed environmentally friendly approach fabricate diverse protein-based plastics. A cost-effective high-level production was through batch fermentation of Escherichia coli produce the...
Open AccessCCS ChemistryRESEARCH ARTICLE21 Jun 2022Contribution of Hydrogen-Bond Nanoarchitectonics to Switchable Photothermal-Mechanical Properties Bioinorganic Fibers Jing Sun†, Jinrui Zhang†, Lai Zhao†, Sikang Wan, Baiheng Wu, Chao Ma, Jingjing Li, Fan Wang, Xiwen Xing, Dong Chen, Hongjie Zhang and Kai Liu Sun† Department Chemistry, Tsinghua University, Beijing 100084 State Key Laboratory Rare Earth Resource Utilization, Changchun Institute Applied Chinese Academy Sciences Changchun,...
Abstract Surgical adhesives are playing an important role in wound repair and emergency hemostasis clinical treatment. However, the development of strong bioglue with rapid situ adhesion, durable adhesiveness, flexibility dynamic moist physiological environments is still challenging. Herein, a new type biosynthetic protein bioadhesives superior adhesion performance reported by developing aldimine condensation strategy. Lysine‐rich recombinant proteins designed massively biosynthesized to...
Abstract Strong and tough bio‐based fibers are attractive for both fundamental research practical applications. In this work, strong hierarchical core–shell with cellulose nanofibrils (CNFs) in the core regenerated silk fibroins (RSFs) shell designed prepared, mimicking natural spider silks. CNF/RSF precisely controlled morphology continuously wet‐spun using a co‐axial microfluidic device. Highly‐dense non‐covalent interactions introduced between negatively‐charged CNFs positively‐charged...
Generating strong adhesion by engineered proteins has the potential for high technical applications. Current studies of adhesive are primarily limited to marine organisms, e.g., mussel proteins. Here, we present a modular engineering strategy generate type exotic protein adhesives with super behaviors. In complexes, lanmodulin (LanM) underwent α-helical conformational transition induced lanthanides, thereby enhancing stacking density and molecular interactions protein. The resulting...
Adhesives have attracted a great deal of attention as an advanced modality in biomedical engineering because their unique wound management behavior. However, it is grand challenge for current adhesive systems to achieve robust adhesion due tenuous interfacial bonding strength. Moreover, the absence dynamic adaptability conventional chemical adhesives restricts neoblasts around from migrating site, resulting inferior tissue-regeneration effect. Herein, extracellular matrix-derived...
Abstract Generating strong adhesion by engineered proteins has the potential for high technical applications. Current studies of adhesive are primarily limited to marine organisms, e.g., mussel proteins. Here, we present a modular engineering strategy generate type exotic protein adhesives with super behaviors. In complexes, lanmodulin (LanM) underwent α‐helical conformational transition induced lanthanides, thereby enhancing stacking density and molecular interactions protein. The resulting...
Abstract Degradable bioplastics have attracted growing interest worldwide. However, it is challenging to develop with a simple processing procedure, strong mechanical performance, good biocompatibility, and adjustable physicochemical properties. Herein, we introduced structural proteins as building blocks developed environmentally friendly approach fabricate diverse protein‐based plastics. A cost‐effective high‐level production was through batch fermentation of Escherichia coli produce the...
Nanodrugs have attracted increasing interest in drug delivery and disease treatment. However, the cumbersome preparation process poor biocompatibility of nanodrugs obstruct their clinical translation. In this study, we utilized a self-assembly strategy to develop low-toxicity, long-lasting nanodrug for effective treatment real-time monitoring bladder tumors. The accurate compatible raw materials allowed an encapsulation rate 43.7% insoluble erdafitinib. Interestingly, robust therapeutic...