A5101904147- Helicobacter pylori-related gastroenterology studies
- Protease and Inhibitor Mechanisms
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Galectins and Cancer Biology
- Gastrointestinal motility and disorders
- Pancreatitis Pathology and Treatment
- RNA modifications and cancer
- Inflammatory Bowel Disease
- SARS-CoV-2 and COVID-19 Research
- Endoplasmic Reticulum Stress and Disease
- Pancreatic and Hepatic Oncology Research
- Mechanisms of cancer metastasis
- Peptidase Inhibition and Analysis
- Eosinophilic Disorders and Syndromes
- Radiopharmaceutical Chemistry and Applications
- Pharmacogenetics and Drug Metabolism
- Potassium and Related Disorders
- Liver Disease and Transplantation
- NF-κB Signaling Pathways
- Cancer-related molecular mechanisms research
- Gastroesophageal reflux and treatments
- Hepatitis Viruses Studies and Epidemiology
- Epigenetics and DNA Methylation
- Phytochemical compounds biological activities
Huazhong University of Science and Technology
2024
Tongji Hospital
2024
China Rehabilitation Research Center
2016-2023
Capital Medical University
2016-2023
Sinovac Biotech
2011-2020
First Affiliated Hospital of Henan University of Science and Technology
2013-2017
Leiden University Medical Center
2004-2007
University of Wisconsin–Madison
2006
The First Affiliated Hospital, Sun Yat-sen University
2000
Sun Yat-sen University
2000
Enterovirus 71 (EV71) is a highly infectious agent that causes hand-foot-mouth disease (HFMD) in humans. Effective vaccination against EV71 infection critically important, given the recent outbreak of HFMD Asia-Pacific region, where it has shown significant mortality and morbidity. There currently no approved anti-viral therapy available to treat disease. While several vaccine manufacturers are actively developing vaccines, there international reference standards conduct quality control on...
BackgroundMatrix metalloproteinases (MMPs) are actively involved in the pathogenesis of Crohn's disease (CD). We assessed effect anti-tumor necrosis factor-α (TNF-α) monoclonal antibody infliximab on vitro and vivo expression MMP-2 MMP-9 CD.
Background. 5-HT enhances dextran sulfate sodium- (DSS-) induced colitis and is involved in inflammatory bowel disease (IBD). Matrix metalloproteinases (MMPs) play roles the process of intestinal inflammation. Aims. To examine whether induces MMPs expression mouse colon to enhance DSS-induced colitis. Materials Methods. C57BL/6J (B6) mice were treated with either low-dose (1.0 mg/kg) or high-dose (2.0 by enema, (1.0%) (2.5%) DSS, combined DSS 5-HT. Mouse was analyzed. tissue inhibitors...
Alterations in synthesis and breakdown of extracellular matrix components play a role acute rejection after orthotopic liver transplantation (OLT). Matrix metalloproteinases (MMPs) are capable degrading basement membranes involved the process tissue remodelling inflammation fibrosis.We examined MMP-2 MMP-9 serum 33 patients before during 1 year OLT, 60 controls as well some specimens cirrhotic control tissue.Serum levels OLT were significantly higher compared with decreased approximately 50%...
This study aims to investigate the expression and significance of p57kip2 cyclinD1 in gastric cardia adenocarcinoma (GCA). is a negative regulator cell cycle. On contrary, positive cycle progression.Thirty-two cases GCA tissues adjacent non-cancerous were collected for this study. Immunohistochemistry fluorescence qualitative PCR was used determine level its tissues. Furthermore, correlation between mRNA/protein clinical pathologic parameters analyzed, relationship also evaluated.The...
Pepsinogen (PG) I and II are crucial in the gastric digestive processes. This study is to examine relationship of serum PGI, PGII, PGI/PGII ratio with Helicobacter pylori (Hp) infection, age, sex, body mass index (BMI) subjects Beijing, China.A total 40,383 asymptomatic subjects, who underwent medical examination Beijing Rehabilitation Hospital, were included this study. Serum PG levels measured using chemoluminescence techniques. The BMI data collected, Hp infection was identified 13C-urea...
Human hand, foot, and mouth disease (HFMD) is a serious public health threat with high infection rates in children infants who reside Asia the Pacific regions, no effective drugs are currently available. Enterovirus 71 (EV71) coxsackievirus A16 major etiological pathogens. Based on an essential hydrophobic pocket viral capsid protein VP1, we designed synthesized series of small molecular weight compounds as inhibitors EV71. A potential drug candidate named NLD-22 exhibited excellent...
Helicobacter pylori (H. pylori) is a well-recognized gastroduodenal pathogen and class I carcinogen. Dual oxidase-2 (DUOX2), member of NADPH oxidase family, has several critical physiological functions, including thyroid hormone biosynthesis host mucosal defense.To investigate the effect H. infection on DUOX2 gene expression in human stomach.The biopsies were obtained from patients who underwent endoscopic diagnosis. The patient serum was assayed for two virulence factors pylori, CagA IgG...
Objective To investigate the efficacy of all- trans retinoic acid (ATRA) in human gastric dysplasia. Methods In this double-blind study, patients with precancerous dysplasia or without intestinal metaplasia (IM) received either conventional treatment consisting omeprazole and sucralfate (control group) plus ATRA. Gastric mucosal biopsies were performed before after drug analysed histologically; expression retinoblastoma (Rb) protein HER2 mucosa measured using immunohistochemistry. Results A...
The endoplasmic reticulum stress inositol-requiring enzyme (IRE) 1α/X‑box binding protein (XBP) 1 signaling pathway is involved in the tumorigenesis of breast and prostate cancer. Mucin 2 (MUC2) protects colon tissues from formation tumors. In human colorectal cancer (CRC) role IRE1α, its analogue, IRE1β, has yet to be elucidated. present study, expression levels un‑spliced XBP1u, spliced XBP1s MUC2 surgically resected cancerous adjacent non‑cancerous patients with CRC were investigated....
Summary Background : Fibroblast growth factors play an important role in (patho)physiological processes such as wound healing and tissue repair. We previously showed that basic fibroblast factor is actively involved inflammatory bowel disease processes. In the present retrospective study, we assessed whether serum levels Crohn's patients reflect response to anti‐tumour necrosis factor‐ α antibody infliximab treatment. Aim methods Serum samples, biopsies patient data from a subgroup of...
Inflammatory bowel disease (IBD) is a risk factor in colon cancer. Endoplasmic reticulum (ER) stress associated with IBD and In the current study an azoxymethane (AOM) dextran sulfate sodium (DSS)-induced mouse colonic tumor model was established to analyze expression of ER chaperone molecules. Female C57BL/6 mice were intraperitoneally injected 12 mg/kg AOM. On 7th day following AOM injection, treated 1% DSS supplemented drinking water for 7 days, then followed by 14 days normal water. The...
Integrated traditional Chinese medicine (ITCM) is known to improve health in patients with acute pancreatitis (AP); however, the molecular mechanisms underlying this effect are unknown. AP associated expression of PRSS1 and SPINK1. Thus, present study aimed investigate whether ITCM was able ameliorate by regulating levels protein, serine 1 (PRSS1) peptidase inhibitor, Kazal type (SPINK1). A total 100 were divided at random into two groups. The treatment group treated externally a herbal...
Philadelphia-chromosome negative myeloproliferative neoplasms (MPN) exhibit phenotypic similarities with JAK/STAT-unmutated idiopathic erythrocytosis and thrombocytosis (IE/IT). We aimed to develop a clinical diagnostic model discern MPN IE/IT. A retrospective study was performed on 77 patients 32 IE/IT in our center from January 2018 December 2023. investigated the role of hemogram, cytokine spleen size differentiating among newly onset patients. Independent influencing factors were...