A5087990413- Microbial infections and disease research
- Cellular Mechanics and Interactions
- Bacteriophages and microbial interactions
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Vaccine Coverage and Hesitancy
- Cell Adhesion Molecules Research
- Genomics and Phylogenetic Studies
- Virus-based gene therapy research
- Molecular Biology Techniques and Applications
- Hippo pathway signaling and YAP/TAZ
- Domain Adaptation and Few-Shot Learning
- Cellular transport and secretion
- Milk Quality and Mastitis in Dairy Cows
- Silk-based biomaterials and applications
- Identification and Quantification in Food
- Advanced Image and Video Retrieval Techniques
- Gene expression and cancer classification
- Food Supply Chain Traceability
- Ichthyology and Marine Biology
- vaccines and immunoinformatics approaches
- 3D Printing in Biomedical Research
- Biochemical and Structural Characterization
Shanghai Jiao Tong University
2023-2025
Ministry of Education of the People's Republic of China
2025
Xi'an Jiaotong University
2023-2025
Peking University
2015
Southwest University
2012
<h3>Importance</h3> Although effective vaccines against COVID-19 have been developed, additional are still needed. <h3>Objective</h3> To evaluate the efficacy and adverse events of 2 inactivated vaccines. <h3>Design, Setting, Participants</h3> Prespecified interim analysis an ongoing randomized, double-blind, phase 3 trial in United Arab Emirates Bahrain among adults 18 years older without known history COVID-19. Study enrollment began on July 16, 2020. Data sets used for were locked...
A vaccine against COVID-19 is urgently needed for older adults, in whom morbidity and mortality due to the disease are increased. We aimed assess safety, tolerability, immunogenicity of a candidate vaccine, CoronaVac, containing inactivated SARS-CoV-2, adults aged 60 years older.We did randomised, double-blind, placebo-controlled, phase 1/2 clinical trial CoronaVac healthy Renqiu (Hebei, China). Vaccine or placebo was given by intramuscular injection two doses (days 0 28). Phase 1 comprised...
Cells sense and respond to the matrix by exerting traction force through binding of integrins an integrin-specific ligand. Here, Arg-Gly-Asp (RGD) peptide is covalently conjugated double-stranded DNA (dsDNA) stem-loop (slDNA) tethers with a tension tolerance 43pN immobilized on PEG substrate. Unlike dsDNA, which ruptured under high tension, leading removal RGD, slDNA remains bound even when ruptured. Our results suggest that cells adapt their adhesion state modulating actin filament...
Streptococcus suis is a significant zoonotic pathogen that great threat not only to the swine industry but also human health, causing arthritis, meningitis, and even streptococcal toxic shock-like syndrome. Owing its many serotypes high geographic variability, an efficacious cross-protective S. vaccine readily available. Therefore, this study aimed design universal multi-epitope (MVHP6) involved three highly immunogenic proteins of suis, namely, surface antigen containing glycosaminoglycan...
The complete mitogenome sequence of a vulnerable species Onychostoma lini was determined using polymerase chain reaction and directly sequenced with primer walking method. 16,595 bp in length, containing 37 genes 13 protein-coding genes, 22 tRNA 2 rRNA control region (D-loop). gene order composition O. similar to most other fishes. descending the base on heavy strand 31.6% A, 27.9% C, 24.6% T, 15.9% G, relatively lower level G slight AT bias 56.2%. codon usage followed typical vertebrate...
Abstract Dynamically evolving adhesions between cells and extracellular matrix (ECM) transmit time‐varying signals that control cytoskeletal dynamics cell fate. Dynamic adhesion ECM stiffness regulate cellular mechanosensing cooperatively, but it has not previously been possible to characterize their individual effects because of challenges with controlling these factors independently. Therefore, a DNA‐driven molecular system is developed wherein the integrin‐binding ligand RGD can be...
Recently, generative Text-based visual question answering (TextVQA) methods, which are often based on language models, have exhibited impressive results and drawn increasing attention. However, due to the inconsistencies in both input forms optimization objectives, power of pretrained models is not fully explored, resulting need for large amounts training data. In this work, we rethink characteristics TextVQA task find that scene text indeed a special kind embedded images. To end, propose...
To develop an analytic method for identifying tissue-specific (TS) genes from RNA-seq data.Based on a negative binomial distribution, we statistical containing consecutive procedures incorporating data variability replicates in each tissue.Simulations show that our approach can effectively identify at least 94% of the truly TS if sample size is 3 and 84% detected by are genes. We illustrated utility in-house project produced sensible results.Our not only directly works discrete but also...
Bovine mastitis (BM) is mainly caused by bacterial infection that has a highly impact on dairy production, affecting both economic viability and animal well-being. A cross-sectional study was conducted in farms to investigate the prevalence antimicrobial resistance patterns of pathogens associated with BM. The analysis revealed Staphylococcus (49%), Pseudomonas (11%), Escherichia (16%), Klebsiella (6%) were primary mastitis. significant proportion strains displayed multiple drug...
Enterotoxigenic Escherichia coli (ETEC) is a major pathogen causing diarrhea in humans and animals, with increasing antimicrobial resistance posing growing challenge recent years. Lytic bacteriophages (phages) offer targeted environmentally sustainable approach to combating bacterial infections, particularly eliminating drug-resistant strains. In this study, ETEC strains were utilized as indicators, stable, high-efficiency phage, designated vB_EcoM_JE01 (JE01), was isolated from pig farm...
Mechanotransduction Article number 2302421 reports that cyclical adhesion can alter stem cell perception of extracellular microenvironment stiffness and thereby controls their mechanosensing fate commitment. Min Lin co-workers demonstrate through integrated modeling experiment accelerate cytoskeletal kinetics amplify nuclear mechanosensing. These findings have direct application for therapies broad implications study development.