A5054170984- Microbial infections and disease research
- Bacteriophages and microbial interactions
- Streptococcal Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Biochemical and Structural Characterization
- vaccines and immunoinformatics approaches
- Genomics and Phylogenetic Studies
- Virus-based gene therapy research
- Milk Quality and Mastitis in Dairy Cows
- Berberine and alkaloids research
- Antibiotic Resistance in Bacteria
- Animal Virus Infections Studies
- Food Supply Chain Traceability
- Plant Pathogenic Bacteria Studies
- Neonatal and Maternal Infections
- Alkaloids: synthesis and pharmacology
Shanghai Jiao Tong University
2023-2025
Nanjing Agricultural University
2022-2024
Streptococcus suis (S. suis) is a zoonotic pathogen with multiple serotypes, and thus, multivalent vaccines generating cross-protection against S. infections are urgently needed to improve animal welfare reduce antibiotic abuse. In this study, we established systematic comprehensive epitope prediction pipeline based on immunoinformatics. Ten candidate epitopes were ultimately selected for building the multi-epitope vaccine (MVSS) infections. The ten of MVSS all derived from highly conserved,...
Streptococcus suis is a significant zoonotic pathogen that great threat not only to the swine industry but also human health, causing arthritis, meningitis, and even streptococcal toxic shock-like syndrome. Owing its many serotypes high geographic variability, an efficacious cross-protective S. vaccine readily available. Therefore, this study aimed design universal multi-epitope (MVHP6) involved three highly immunogenic proteins of suis, namely, surface antigen containing glycosaminoglycan...
Bovine mastitis is a prevalent infectious disease in dairy herds worldwide, resulting substantial economic losses. Staphylococcus aureus major cause of animals, and its antibiotic resistance poses challenges for treatment. Recently, renewed interest has focused on the development alternative methods to therapy, including bacteriophages (phages), controlling bacterial infections. In this study, 2 lytic phages, vB_SauM_JDYN (JDYN) vB_SauM_JDF86 (JDF86), were isolated from cattle sewage...
Bovine mastitis (BM) is mainly caused by bacterial infection that has a highly impact on dairy production, affecting both economic viability and animal well-being. A cross-sectional study was conducted in farms to investigate the prevalence antimicrobial resistance patterns of pathogens associated with BM. The analysis revealed Staphylococcus (49%), Pseudomonas (11%), Escherichia (16%), Klebsiella (6%) were primary mastitis. significant proportion strains displayed multiple drug...
Enterotoxigenic Escherichia coli (ETEC) is a major pathogen causing diarrhea in humans and animals, with increasing antimicrobial resistance posing growing challenge recent years. Lytic bacteriophages (phages) offer targeted environmentally sustainable approach to combating bacterial infections, particularly eliminating drug-resistant strains. In this study, ETEC strains were utilized as indicators, stable, high-efficiency phage, designated vB_EcoM_JE01 (JE01), was isolated from pig farm...
Abstract Streptococcus suis is an important emerging zoonosis that causes economic losses in the pig industry and severe threats to public health. Transcriptional regulators play essential roles bacterial adaptation host environments. In this study, we identified a novel XRE family transcriptional regulator S. CZ130302, XtrSs, involved fitness hydrogen peroxide stress. Based on electrophoretic mobility shift β-galactosidase activity assays, found XtrSs autoregulated its own transcription...