A5100646367- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Tracheal and airway disorders
- Medical Imaging and Pathology Studies
- Cancer-related Molecular Pathways
- Metastasis and carcinoma case studies
- Renal cell carcinoma treatment
- Cancer Research and Treatments
- Pancreatitis Pathology and Treatment
- Mesenchymal stem cell research
- Esophageal Cancer Research and Treatment
- Bladder and Urothelial Cancer Treatments
- Lung Cancer Treatments and Mutations
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Urinary and Genital Oncology Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Reproductive System and Pregnancy
- Sarcoma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Neuroendocrine regulation and behavior
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Neurological Disease Mechanisms and Treatments
Roswell Park Comprehensive Cancer Center
2004-2024
Zigong First People's Hospital
2024
Huazhong University of Science and Technology
2021
Kunming Medical University
2021
First People's Hospital of Chongqing
2020
Tianjin Medical University Cancer Institute and Hospital
2011-2020
Inner Mongolia Agricultural University
2020
Peking University
2020
Beijing Hospital
2020
National Clinical Research
2020
Abstract Introduction Growing evidence has brought stem cell therapy to the forefront as new promising approaches towards stroke treatment. Of all candidate seeding cells, adipose-derived cells (ADSCs) are considered one of most appropriate for However, previous experimental data could not reach an agreement on efficacy ADSC transplantation treating in vivo well its mechanism which hinders their further clinical translational application. Methods To explore hADSC administration neurological...
Anderson, Craig S.; Heeley, Emma; Huang, Yining; Wang, Jiguang; Stapf, Christian; Delcourt, Candice; Lindley, Richard; Robinson, Thompson; Lavados, Pablo; Neal, Bruce; Hata, Jun; Arima, Hisatomi; Parsons, Mark; Li, Yuechun; Jinchao; Heritier, Stephane; Qiang; Woodward, Simes, R. John; Davis, Stephen M.; Chalmers, John for the INTERACT2 (Second Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial) Investigators Author Information
Abstract Background We describe the clinical features, genetic profile, and their correlation in NSCLC patients. Methods A total of 256 Chinese patients with were enrolled this study. NGS‐based genomic profiling major lung cancer‐related genes was performed on formalin‐fixed paraffin‐embedded tumor samples. Results Of NSCLC, 219 adenocarcinoma most them early stage. Among patients, 63.3% have more than two gene mutations. By analyzing variant allele frequency (VAF), we found that median VAF...
Colorectal cancer is one of the most frequent causes cancer-related deaths worldwide. Thus, there a need for timely diagnosis and effective treatment. Our aim in present study was to detect serum level trefoil factor 3 protein evaluate diagnostic accuracy patients with colorectal cancer. We collected samples from 204 participants (127 cancer, 35 polyps, 42 healthy controls). The levels carcinoembryonic antigen expression were measured by enzyme-linked immunosorbent assay. Receiver operating...
Heart failure (HF) has been proposed as a potential indication of renal denervation (RDN). However, the mechanisms enabling RDN to attenuate HF are not well understood, especially central effects RDN. The aim this study was decipher mode operation in treatment using canine model right ventricular rapid pacing-induced heart failure. Accordingly, 24 Chinese Kunming dogs were randomly grouped receive sham procedure (Sham-operated group), bilateral (RDN pacing induce (HF-control and plus (RDN+HF...
Colorectal cancer (CRC), a common malignant tumor in the digestive tract, is leading cause of cancer-related death. SPRY4 has been reported to act as suppressor gene various tumors. This study aims assess role colorectal (CRC) and uncover its underlying mechanisms. Firstly, expression levels were measured CRC cell lines. SPRY4-overexpressing or silencing plasmids transfected into cells regulate level. CCK-8, colony formation, EdU assay, wound-healing Transwell assays performed determine...
Although cigarette smoking is a principal risk factor for bladder cancer in both men and women, few studies have statistically evaluated whether gender modifies the effect of on risk. We initiated present case-control study at Roswell Park Cancer Institute Buffalo, New York, U.S., to provide further data this important issue. observed similar estimates women with comparable exposures, but did not observe significant interaction between lifetime exposure. conclude that major sexes, does modify
Herpesvirus entry mediator (HVEM) displays dual signals in T‑cell activation according to the ligands and intracytoplasmic effectors it interacts with. High HVEM expression may play an immunosuppressive role several malignancies. The present study investigated clinical impact of on intrahepatic cholangiocarcinoma (ICC), including its prognostic value, association with clinicopathological features immune status. data 102 consecutive patients ICC who underwent surgical treatment from January...
This study examined the relationship between expression of p16, a tumor suppressor gene, and lymph node metastasis, as well patient prognosis, in cases with ovarian cancer. SKOV-3, an cancer cell line, IOSE80, normal human were selected for testing. Western blot analysis was used to detect p16 culture samples. In study, 20 tissue 64 tissue, including 38 metastasis 26 without also Immunohistochemical techniques protein The influence on SKOV-3 invasion ability studied using gene...
To detect the expressions of thyroid transcription factor-1 (TTF-1) and p63 in non-small cell lung cancer (NSCLC) to evaluate their clinical significance.The expression TTF-1 from 404 NSCLC 28 benign pulmonary disease (BPD) tissue specimens were detected by immunohistochemical EnVision two-step method, together with clinicopathologic data.The positive rate protein tissues was 51.7% (209/404) 37.9% (153/404), respectively, while negative BPD group. There overexpression female gender...
Abstract Background Sepsis is triggered by pathogenic microorganisms, resulting in a systemic inflammatory response. Liver cirrhosis and sepsis create vicious cycle: weakens immune function, raising infection risk hindering pathogen clearance. Optimal treatment outcomes depend on understanding liver patients’ factors. Thus, preventing involves addressing these Therefore, early identification of clinical characteristics patients with are crucial for selecting appropriate antibiotics. A...
Lung nodule segmentation in computed tomography (CT) plays an important role computer-aided detection, diagnosis, and quantification systems for lung cancer. In this study, we developed a simple but accurate method three-dimensional (3D) CT. First, volume of interest (VOI) was determined at the location nodule. We then transformed VOI into two-dimensional (2D) image by use "spiral-scanning" technique, which radial line originating from center spirally scanned VOI. The voxels were arranged...