A5015058918- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Metal-Organic Frameworks: Synthesis and Applications
- Enzyme Production and Characterization
- CAR-T cell therapy research
- Electrochemical sensors and biosensors
- Invertebrate Immune Response Mechanisms
- Probiotics and Fermented Foods
- Silkworms and Sericulture Research
- Child Nutrition and Water Access
- Prenatal Screening and Diagnostics
- Environmental Toxicology and Ecotoxicology
- Air Quality and Health Impacts
- Nanoparticles: synthesis and applications
- Covalent Organic Framework Applications
- Enzyme Catalysis and Immobilization
- Erythropoietin and Anemia Treatment
- Advanced Glycation End Products research
- Nanomaterials for catalytic reactions
- Vitamin D Research Studies
- Advanced Nanomaterials in Catalysis
- Insect Resistance and Genetics
- Biomedical and Engineering Education
- Parathyroid Disorders and Treatments
- Adsorption and biosorption for pollutant removal
Jiangsu University
2018-2025
Dana-Farber Cancer Institute
2024
Massachusetts General Hospital
2024
In this work, a trimetallic (Ni/Co/Zn) organic framework (tMOF), synthesized by solvothermal method, was calcinated at 400 and 600 °C the final products were used as support for lipase immobilization. The material annealed (Ni-Co-Zn@400) had an improved surface area (66.01 m2/g) pore volume (0.194 cm3/g), which showed highest enzyme loading capacity (301 mg/g) with specific activity of 0.196 U/mg, could protect against thermal denaturation 65 °C. optimal pH temperature 8.0 45 but tolerate...
Glucoamylases (GLL) hydrolyze starch to glucose syrup without yielding intermediate oligosaccharides, but their lack of stability under industrial conditions poses a major limiting factor. Using consensus- and ancestral-based machine-learning tools, functional GLL with six mutations (GLLI73l/T130V/N212V/D238G/N327M/S332P) was constructed that exhibited superior hydrolytic activity relative the wild-type (WT-GLL). An oxidized multi-walled carbon nanotube (oMW-CNT) used as solid support...
β‐Galactosidases are crucial enzymes that hydrolyse oligosaccharides and polysaccharides with terminal β‐1,4‐glycosidic bonds. Though the traditional application of has been to catalyse breakdown lactose in dairy products, its extends beyond production lactose‐free products since variants capable facilitating condensation exhibiting galactosyl transferase activity extensively utilised for synthesis prebiotic galacto‐oligosaccharides. This review analyses β‐Galactosidase multiple aspects,...
In the enzymatic conversion of biomass, it becomes an important issue to efficiently and cost-effectively degrade cellulose into fermentable glucose. β-Glucosidase (Bgluc), essential member cellulases, plays a critical role in cellulosic biomass degradation. The difficulty improving stability Bgluc has been bottleneck enzyme-dependent traditional method protein purification, however, leads higher production cost decrease activity. To simplify purify with modified special properties,...
Human epidermal growth factor receptor 2 (HER2) is an overexpressed antigen in esophageal squamous cell carcinomas (ESCCs) but with limited expression levels normal tissues. Therefore, employing the adoptive transfer of T cells genetically modified to express chimeric (CAR) targeting HER2 could be a promising therapeutic strategy against ESCC.Two different second-generation CAR-T expressing antibodies for and CD19 antigens were developed using retroviral vector transduction. The ESCC tissue...
Long-standing goals of cancer immunotherapy are to activate cytotoxic antitumor T cells across a broad range affinities while dampening suppressive regulatory (Treg) cell responses, but current approaches achieve these with limited success. Here, we report