A5103053878- Alzheimer's disease research and treatments
- Trace Elements in Health
- Ferroptosis and cancer prognosis
- Neurological Disease Mechanisms and Treatments
- Pancreatitis Pathology and Treatment
- Tryptophan and brain disorders
- Nitric Oxide and Endothelin Effects
- Hydrogen's biological and therapeutic effects
- Phagocytosis and Immune Regulation
- Microbial Metabolic Engineering and Bioproduction
- Antioxidants, Aging, Portulaca oleracea
- Nanoplatforms for cancer theranostics
- Traditional Chinese Medicine Analysis
- Nanoparticle-Based Drug Delivery
- Autophagy in Disease and Therapy
- Biochemical effects in animals
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- Pancreatic function and diabetes
- Sepsis Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Pancreatic and Hepatic Oncology Research
China Three Gorges University
2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2016-2024
Youjiang Medical College for Nationalities
2013-2024
Guangxi Medical University
2012-2014
Acute pancreatitis is characterized by zymogen pre-activation. Severe inflammation caused activation can eventually lead to multiple organ dysfunctions, which contributes the high mortality rate of severe acute pancreatitis. However, there no specific treatment available for therapy. Here, we show that spautin-1, effectively inhibits autophagy flux, ameliorated pathogenesis induced cerulein or L-Arginine. CaMKII phosphorylation due cytosolic calcium oeverload was revealed in this paper. It...
Effect and mechanism of Yulangsan flavonoid (YLSF) on rat myocardial ischemia/reperfusion injury (MI/RI) has been investigated.Sprague-Dawley (SD) rats were randomly divided into seven groups (sham group, model group NS group: 2 mL normal saline/kg body weight was administered; diltiazem 5 mg hydrochloride/kg YLSFL, YLSFM YLSFH groups: 20, 40 80 YLSF/kg administered) the MI/RI established. Myocardial infarct area, levels enzymes nitric oxide synthase (NOS) measured. Caspase-3 adenine...
The present study aimed to validate the association between core cuproptosis genes (CRGs) and Alzheimer's disease (AD) from both bioinformatics experimental perspectives also develop a risk prediction model. To this end, 78 human‑derived temporal back samples were analyzed GSE109887, biological functions of resulting CRGs explored by cluster analysis, weighted gene co‑expression network analysis similar methods identify best machine Moreover, an external dataset GSE33000 nomogram used mRNA...
This study aimed to evaluate the therapeutic efficacy and effect of blood purification (BP) therapy on severe acute pancreatitis (SAP). Information 305 patients (BP group 68, control 237) diagnosed with SAP was retrieved from Medical Mart for Intensive Care IV (MIMIC IV) database. Firstly, influence BP treatment preliminarily evaluated by comparing outcome indicators two groups. Secondly, multiple regression analysis used screen mortality risk factors verify impact survival patients. Then,...
The present study established a mouse model of depression induced by unpredictable chronic mild stress. mice were treated with Yulangsan polysaccharide (YLSPS; 150, 300 and 600 mg/kg) for 21 days, compared fluoxetine-treated normal control groups. Enzyme-linked immunosorbent assay, radioimmunity immunohistochemical staining showed that following treatment YLSPS (300 mg/kg), monoamine neurotransmitter levels, prefrontal cortex adenylate cyclase activity hippocampal brain-derived neurotrophic...
Abstract This study aimed to validate the correlation between core cuproptosis genes (CRGs) and Alzheimer's disease (AD) from both bioinformatics experimental perspectives also develop a risk prediction model. To this end, 78 human-derived temporal back samples were analyzed in GSE109887, then biological functions of resulting CRGs explored by cluster analysis, weighted gene co-expression network analysis (WGCNA), similar methods identify best machine Moreover, nomogram was developed The...