A5032597404- Syphilis Diagnosis and Treatment
- Hearing, Cochlea, Tinnitus, Genetics
- Tattoo and Body Piercing Complications
- Hearing Loss and Rehabilitation
- Ear Surgery and Otitis Media
- Vestibular and auditory disorders
- Electromagnetic wave absorption materials
- Medicinal Plants and Bioactive Compounds
- IL-33, ST2, and ILC Pathways
- Genomics, phytochemicals, and oxidative stress
- Ear and Head Tumors
- Sinusitis and nasal conditions
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Plant Molecular Biology Research
- Fungal Biology and Applications
- Streptococcal Infections and Treatments
Sun Yat-sen Memorial Hospital
2023-2025
Sun Yat-sen University
2023-2025
Cisplatin is widely employed in clinical oncology as an anticancer chemotherapy drug practice and known for its severe ototoxic side effects. Prior research indicates that the accumulation of reactive oxygen species (ROS) plays a pivotal role cisplatin's inner ear toxicity. Hesperidin flavanone glycoside extracted from citrus fruits has anti-inflammatory antioxidant Nonetheless, specific pharmacological actions hesperidin alleviating cisplatin-induced ototoxicity remain elusive. The...
The maturity and spatial distribution of tertiary lymphoid structures (TLSs) vary dynamically within between cancers, leading to a controversial role in cancer. We aimed develop simple morphology-based approach identify the TLSs laryngeal squamous cell carcinoma examine their clinically relevant functional role.TLSs were identified based on morphological features via hematoxylin eosin (H&E) staining, accuracy was verified by multi-immunohistochemical analysis. density, maturity, prognostic...
Abstract Adeno‐associated virus (AAV) vectors are a leading platform for gene therapy. Recently, AAV‐mediated therapy in the inner ear has progressed from laboratory use to clinical trials, but lower transduction rates outer hair cells (OHCs) organ of Corti and vestibular adult mice still pose challenge. OHCs particularly vulnerable insults. In this study, we demonstrated that expression key AAV receptor (AAVR, Kiaa0319l , or Au040320 ) decreases significantly mature particles directly...
Over-production of reactive oxygen species (ROS) in the inner ear can be triggered by a variety pathological events identified animal models after traumatic noise exposure. Our previous research found that inhibition AMP-activated protein kinase alpha subunit (AMPKα) protects against noise-induced cochlear hair cell loss and hearing reducing ROS accumulation. However, molecular pathway through which AMPKα exerts its antioxidative effect is still unclear. In this study, we have investigated...
Objectives To determine the morphologies and effect of round window niche veil (RWNV) on local drug delivery efficacy develop diagnostic criteria high‐resolution computed tomography (HRCT). Methods Patients diagnosed with otosclerosis, bilateral profound sensorineural hearing loss or vestibular schwannoma were enrolled from 2019 to 2022, receiving temporal bone HRCT scanning, anatomic variations RWMV summarized intraoperative. For patients schwannoma, 1 mL dexamethasone solution (4 mg/mL)...
Chronic otitis media (COM) is an inflammatory disease that commonly presents with otorrhea and hearing loss. Bacteria-induced inflammation can cause inner ear damage, leading to sensorineural loss (SNHL). This study aimed compare the prevalence severity of SNHL in patients gram-negative versus gram-positive cultures examine associations between concentrations circulating monocytes neutrophils bacteria species SNHL.
Cisplatin (CDDP) is a commonly used chemotherapeutic agent for treating head and neck tumors. However, there high incidence of ototoxicity in patients treated with CDDP, which may be caused by the excessive reactive oxygen species (ROS) generation inner ear. Many studies have demonstrated strong antioxidant effects ergothioneine (EGT). Therefore, we assumed that EGT could also attenuate cisplatin-induced hearing loss (CIHL) as well. protective effect mechanism on CIHL not been elucidated so...
The authors declare that they have no known competing financial interests or personal relationships could appeared to influence the work reported in this paper. conflicts of interest. peer review history for article is available at https://www.webofscience.com/api/gateway/wos/peer-review/10.1111/coa.14224. confirm data supporting findings study are within article.