A5005178802- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Epigenetics and DNA Methylation
- Protist diversity and phylogeny
- Respiratory Support and Mechanisms
- Sarcoidosis and Beryllium Toxicity Research
- Bone health and treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Adenosine and Purinergic Signaling
- RNA modifications and cancer
- Cystic Fibrosis Research Advances
- Hydrogen's biological and therapeutic effects
University of Pittsburgh
2018-2021
University of Pittsburgh Medical Center
2020
ABSTRACT Airway hydration and ciliary function are critical to airway homeostasis dysregulated in chronic obstructive pulmonary disease (COPD), which is impacted by cigarette smoking has no therapeutic options. We utilized a high-copy cDNA library genetic selection approach the amoeba Dictyostelium discoideum identify protectors smoke. Members of mitochondrial ADP/ATP transporter family adenine nucleotide translocase (ANT) protective against smoke human bronchial epithelial cells. Gene...
Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disease associated with aberrant activation and differentiation of fibroblasts, leading to abnormal extracellular matrix production. Currently, it still an untreatable (except for transplantation). Here, we demonstrate that the Raf1 inhibitor GW5074 ameliorates in bleomycin-induced fibrosis. Posttreatment reduced fibronectin (FN) expression, collagen deposition, inflammatory cell infiltration bleomycin-challenged mice, suggesting...
Abstract Airway hydration and ciliary function are critical to airway homeostasis dysregulated in chronic obstructive lung disease (COPD). COPD is the 4 th leading cause of death US impacted by cigarette smoking with no therapeutic options. We utilized a genetic selection approach amoeba Dictyostelium discoideum as comparative discovery tool biology identify protectors from smoke (CS). Adenine nucleotide translocase (ANT), mitochondrial ADP/ATP transporter, was protective against CS human...
Chronic obstructive pulmonary disease (COPD) is a destructive lung resulting in alveolar tissue loss, airway remodeling and inflammation with cigarette smoke (CS) being major causative factor. Mitochondrial dysfunction can lead to changes cell fate implicated COPD. Cellular senescence, state of cycle arrest, results abnormal responses epithelial cells. An important protein mitochondrial metabolism adenine nucleotide translocase (ANT), ATP transporter. Our studies suggest that levels ANT are...