A5059937661- Retinal Diseases and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Phagocytosis and Immune Regulation
- Retinal Imaging and Analysis
- Sphingolipid Metabolism and Signaling
- Retinal Development and Disorders
- Advanced Glycation End Products research
- Retinopathy of Prematurity Studies
- Long-Term Effects of COVID-19
- Telomeres, Telomerase, and Senescence
- Retinal and Optic Conditions
- Acute Myeloid Leukemia Research
- Receptor Mechanisms and Signaling
- Olfactory and Sensory Function Studies
- Ocular Surface and Contact Lens
- Research on Leishmaniasis Studies
- Insect Resistance and Genetics
- Protein Kinase Regulation and GTPase Signaling
- Trypanosoma species research and implications
- DNA Repair Mechanisms
- Plant Micronutrient Interactions and Effects
- Angiogenesis and VEGF in Cancer
- Biochemical and Molecular Research
- Plant Stress Responses and Tolerance
University of British Columbia
2024
Indian Institute of Science Education and Research, Tirupati
2018-2023
The Ohio State University
2013-2017
Michigan State University
2012-2017
Michigan United
2016
Indian Institute of Science Bangalore
2010
Activation of pro-inflammatory and pro-angiogenic pathways in the retina bone marrow contributes to pathogenesis diabetic retinopathy. We identified miR-15a as key regulator both through direct binding inhibition central enzyme sphingolipid metabolism, ASM, growth factor, VEGF-A. was downregulated cells. Over-expression downregulated, upregulated ASM VEGF-A expression retinal In addition effects, migration vascular repair function impaired inhibitor-treated circulating angiogenic cells...
Abstract The metabolic insults associated with diabetes lead to low-grade chronic inflammation, retinal endothelial cell damage, and inadequate vascular repair. This is partly due the increased activation of bone marrow (BM)-derived proinflammatory monocytes infiltrating retina, compromised function BM-derived reparative circulating angiogenic cells (CACs), which home sites injury foster We now propose that a link leading activated dysfunctional CACs in involves upregulation central enzyme...
Diabetic retinopathy is a sight-threatening complication of diabetes, affecting 65% patients after 10 years the disease. metabolic insult leads to chronic low-grade inflammation, retinal endothelial cell loss and inadequate vascular repair. This partly due bone marrow (BM) pathology leading increased activity BM-derived pro-inflammatory monocytes impaired function reparative circulating angiogenic cells (CACs). We propose that diabetes has significant long-term effect on nature proportion...
Diabetic retinopathy is a microvascular disease that results from retinal vascular degeneration and defective repair due to diabetes-induced endothelial progenitor dysfunction.
Trypanosoma evansi infections, commonly called 'surra', cause significant economic losses to livestock industry. While this infection is mainly restricted large animals such as camels, donkeys and equines, recent reports indicate their ability infect humans. There are no World Animal Health Organization (WAHO) prescribed diagnostic tests or vaccines available against disease the drugs show toxicity. an urgent need develop improved methods of diagnosis control measures for disease. Unlike its...
Abstract Ataxia telangiectasia mutated (ATM) acts as a defense against variety of bone marrow (BM) stressors. We hypothesized that ATM loss in BM-hematopoietic stem cells (HSCs) would be detrimental to both HSC function and microvascular repair while sustained beneficial disease models diabetes. Chronic diabetes represents condition associated with depletion inadequate vascular repair. Gender mismatched chimeras ATM−/− on wild type background were generated cohort made diabetic using...
Plants commonly respond to stressors by modulating the expression of a large family calcium binding proteins including isoforms ubiquitous signaling protein calmodulin (CaM). The various plant CaM are thought differentially regulate activity specific target modulate cellular stress responses. mechanism(s) behind differential activation CaMs is unknown. In this study, we used steady-state and stopped-flow fluorescence spectroscopy investigate strategy which two soybean (sCaM1 sCaM4) have...
Mallikarjuna Nimgampallea, Hemanth Naick Banavatha, Harshini Chakravarthya , Ambrish Saxenab# & Vasudharani Devanathana* a Department of Biological Sciences, Indian Institute Science Education and Research (IISER) Tirupati, Andhra Pradesh, India; b Syngene International Ltd, Bangalore, Karnataka, India
Culture of adult neurons the central nervous system (CNS) can provide a unique model to explore neurodegenerative diseases. The CNS includes and glia brain, spinal cord retina. Neurons in retina have advantage being most accessible cells CNS, serve as reliable mirror brain. Typically, primary cultures utilize fetal rodent neurons, but very rarely from larger mammals. Here, we cultured retinal isolated goat up 10 days, established an vitro hyperglycemia for performing morphological molecular...
Pterygium is often associated with chronic ultraviolet (UV) radiation exposure and characterized by the overgrowth of conjunctiva extracellular matrix (ECM) remodeling. Notably, several studies in skin have demonstrated that UV can upregulate Granzyme B (GrB) expression increase ECM degradation. The aim this study was to compare GrB between pterygium healthy controls further link mast cells. Post-mortem tissues conjunctival from age-matched were used assess via immunofluorescence microscopy....