A5012617968- Computational Drug Discovery Methods
- COVID-19 Clinical Research Studies
- Neuroscience and Neuropharmacology Research
- SARS-CoV-2 and COVID-19 Research
- Ion channel regulation and function
- Pancreatic function and diabetes
- Glycosylation and Glycoproteins Research
- Retinal and Optic Conditions
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Long-Term Effects of COVID-19
- Ion Channels and Receptors
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Cellular Mechanics and Interactions
- Ion Transport and Channel Regulation
- COVID-19 diagnosis using AI
- Phenothiazines and Benzothiazines Synthesis and Activities
- Signaling Pathways in Disease
- Synthesis and Characterization of Heterocyclic Compounds
- Peptidase Inhibition and Analysis
- Cellular transport and secretion
- Herbal Medicine Research Studies
- Protein Kinase Regulation and GTPase Signaling
Indian Institute of Technology Tirupati
2020-2021
Armed Forces Medical College
2021
Indian Institute of Science Education and Research, Tirupati
2020
Syngene International (India)
2019
Orchid Pharma (India)
2013
University of Tübingen
2011-2012
Heinrich Heine University Düsseldorf
2006-2008
Saint Louis University
1994
The current global pandemic COVID-19 caused by the SARS-CoV-2 virus has already inflicted insurmountable damage both to human lives and economy. There is an immediate need for identification of effective drugs contain disastrous outbreak. Global efforts are underway at a war footing identify best drug combination address disease. In this review, attempt been made understand life cycle, based on information potential druggable targets against summarized. Also, strategies ongoing future...
Klotho, a transmembrane protein, protease and hormone has been shown to exert profound effect on phosphate metabolism. Klotho overexpression lowers deficiency increases the plasma concentration, effects in part attributed an inhibitory of formation 1,25-dihydroxycholecalciferol (1,25(OH) 2D3), active form Vitamin D. Beyond that decrease renal tubular transport more directly. The influence concentration contributes ageing life span. present study explored whether influences major (NaPi-IIa)...
Recently Chloroquine and its derivative Hydroxychloroquine have garnered enormous interest amongst the clinicians health authorities' world over as a potential treatment to contain COVID-19 pandemic. The present research aims at investigating therapeutic of potent against SARS-CoV-2 viral proteins. At same time screening was performed for some chemically synthesized derivatives compared their binding efficacy with through in silico approaches. For purpose study, essential proteins enzymes...
GPR39 is a constitutively active orphan G-protein-coupled receptor capable of increasing serum response element-mediated transcription. We found to be up-regulated in hippocampal cell line resistant against diverse stimulators death and show that its overexpression protects oxidative endoplasmic reticulum stress, as well direct activation the caspase cascade by Bax overexpression. In contrast, silencing rendered cells more susceptible death. An array analysis transcripts induced revealed...
The energy-sensing AMP-activated serine/threonine protein kinase (AMPK) confers cell survival in part by stimulation of cellular energy production and limitation utilization. AMPK-sensitive functions further include activities epithelial Na+ channel ENaC voltage-gated K+ KCNE1/KCNQ1. AMPK is activated an increased cytosolic Ca2+ concentration. present study explored whether regulates the Ca2+-sensitive large conductance potassium (BK) channel. cRNA encoding BK was injected into Xenopus...
The Janus-activated kinase-2 JAK2 is involved in the signaling of leptin and erythropoietin receptors mediates neuroprotective effects hormones. In theory, could be effective through modulation glutamate transporters, carriers accounting for clearance released during neurotransmission. present study thus elucidated effect on transporters EAAT1, EAAT2, EAAT3 EAAT4. To this end, cRNA encoding was injected into Xenopus oocytes with or without transport estimated from induced current (Iglu)....
Glutamate treatment depletes hippocampal HT22 cells of glutathione, which renders the incapable to reduce reactive oxygen species and ultimately cumulates in cell death by oxidative stress. resistant glutamate displayed increased phosphorylation cAMP-response-element binding (CREB) decreased ERK1/2 suggestive differences signal transmission. We investigated amount candidate G-protein-coupled receptors involved this resistance found an increase mRNA for activated vasoactive intestinal peptide...
The asialoglycoprotein (ASGP) receptor undergoes constitutive endocytosis in HepG2 cells, which is regulated by tyrosine kinase activity (Fallon, R. J., Danaher, M., Saylors, L., and Saxena, A. (1994) J. Biol. Chem. 269, 11011-11017). In this study we show that the copurifies with a activity, as defined phosphorylation of an exogenous substrate (reduced carboxyamidomethylated maleylated lysozyme). Analysis cells transfected one subunit ASGP showed signals cytoplasmic domain H1 are sufficient...
Mallikarjuna Nimgampallea, Hemanth Naick Banavatha, Harshini Chakravarthya , Ambrish Saxenab# & Vasudharani Devanathana* a Department of Biological Sciences, Indian Institute Science Education and Research (IISER) Tirupati, Andhra Pradesh, India; b Syngene International Ltd, Bangalore, Karnataka, India
The multifunctional protein ß-catenin governs as transcription factor the expression of a wide variety genes relevant for cell proliferation and survival. In addition, is localized at membrane may influence function channels. present study explored possibility that participates in regulation HERG K+ channel. To this end, was expressed Xenopus oocytes with or without voltage-gated current determined utilizing dual electrode voltage clamp. As result, markedly upregulated channel activity, an...
Recently Chloroquine and its derivative Hydroxychloroquine have garnered enormous interest amongst the clinicians health authorities’ world over as a potential treatment to contain COVID-19 pandemic. The present research aims at investigating therapeutic of potent against SARS-CoV-2 viral proteins. At same time we screened some chemically synthesized derivatives compared their binding efficacy with through in silico approaches. For purpose study, selected essential proteins enzymes...
Recently Chloroquine and its derivative Hydroxychloroquine have garnered enormous interest amongst the clinicians health authorities’ world over as a potential treatment to contain COVID-19 pandemic. The present research aims at investigating therapeutic of potent against SARS-CoV-2 viral proteins. At same time we screened some chemically synthesized derivatives compared their binding efficacy with through <i>in silico</i>approaches. For purpose study, selected essential proteins...
Introduction: A novel beta coronavirus, which was named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), identified to be the causative organism of disease (COVID-19). Aims: To study clinico-epidemiological profile hospitalised COVID-19 cases in an urban area. Material and methods: The workers carried out a cross sectional descriptive study. Period 01 April 2020 31 December 2020. Detailed epidemiological, clinical, laboratory radiological data obtained from each case. Above...