A5001620639- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- Organ Transplantation Techniques and Outcomes
- Complement system in diseases
- Renal Diseases and Glomerulopathies
- Viral Infections and Immunology Research
- Chemokine receptors and signaling
- Evaluation and Optimization Models
- Cytomegalovirus and herpesvirus research
- Blood groups and transfusion
- Plant Micronutrient Interactions and Effects
- Evaluation Methods in Various Fields
- Agriculture, Soil, Plant Science
- Monoclonal and Polyclonal Antibodies Research
- Mast cells and histamine
- Hydrocarbon exploration and reservoir analysis
- Geological formations and processes
- Environmental and Agricultural Sciences
- RNA Interference and Gene Delivery
- Hematopoietic Stem Cell Transplantation
- Spine and Intervertebral Disc Pathology
- Industrial Technology and Control Systems
- Advanced Decision-Making Techniques
Nanjing University
2025
Cedars-Sinai Medical Center
2016-2024
China Geological Survey
2023-2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Xi'an Jiaotong University
2018-2023
Hainan University
2023
Hunan University
2023
Wuhu Fourth People Hospital
2015-2022
Xian Yang Central Hospital
2017-2022
Donor-specific antibodies create an immunologic barrier to transplantation. Current therapies modify donor-specific are limited and ineffective in the most highly HLA-sensitized patients. The IgG-degrading enzyme derived from Streptococcus pyogenes (IdeS), endopeptidase, cleaves human IgG into F(ab')2 Fc fragments inhibiting complement-dependent cytotoxicity antibody-dependent cellular cytotoxicity, which suggests that IdeS might be useful for desensitization. We report on combined...
Among transplant recipients, those who produce antibodies against the donor's human leukocyte antigens (HLAs) are at higher risk for antibody-mediated rejection and vasculopathy, which is a progressive, vasculo-occlusive disease that results in ischemic injury deterioration of organ function. Antibodies HLA class I (HLA-I) molecules thought to contribute vasculopathy by triggering signals elicit activation proliferation endothelial cells. Here, we demonstrate molecular association between...
Background. Chronic antibody-mediated rejection (cAMR) results in the majority of renal allograft losses. Currently, there are no approved therapies. We recently reported on clinical use tocilizumab (TCZ) for treatment cAMR HLA-sensitized kidney transplant patients. IgG 1 and 3 subclasses potent effectors complement- antibody-dependent cellular cytotoxicity, which critical mediators AMR. Here, we examined impact TCZ total IgG, 1-4 subclasses, anti–HLA-IgG (total subclasses). Methods....
Allosensitization represents a major barrier to heart transplantation (HTx). We assessed the efficacy and safety of complement inhibition at transplant in highly sensitized recipients. performed single-center, single-arm, open-label trial (NCT02013037). Patients with panel reactive antibodies (PRA) ≥70% pre-formed donor-specific (DSA) were eligible. In addition standard care, patients received nine infusions eculizumab during first 2 months posttransplant. The primary composite endpoint was...
Interleukin-6 (IL-6) is an important mediator of inflammation and activation T cells, B plasma cells. Excessive IL-6 production linked to human diseases characterized by unregulated antibody production, including alloimmunity, where persistence donor-specific antibodies (DSAs), chronic active antibody-mediated rejection (cAMR), graft loss are noted. Here, we report our experience investigating clazakizumab, a novel inhibitor, in treating leukocyte antigen (HLA)-sensitized patients with...
The presence of antibodies to angiotensin type 1 receptor (AT1R) and endothelin A (ETAR) is associated with allograft rejection in kidney heart transplantation. aim our study was determine the impact AT1R ETAR on graft outcome lung transplantation.Pretransplant posttransplant sera from 162 recipients transplanted at 3 centers between 2011 2013 were tested for by enzyme-linked immunosorbent assay (ELISA) assay. Clinical parameters analyzed were: HLA transplant, de novo donor-specific (DSA),...
Abstract Transplant recipients developing donor-specific HLA class II (HLA-II) Abs are at higher risk for Ab-mediated rejection (AMR) and transplant vasculopathy. To understand how HLA-II cause AMR vasculopathy, we determined the signaling events triggered in vascular endothelial cells (EC) following Ab ligation of molecules. expression EC was induced by adenoviral vector CIITA or pretreatment with TNF-α/IFN-γ. stimulated proliferation migration. Class also activation key nodes Src, focal...
Mangrove forests play a vital role in maintaining ecological balance coastal regions. Accurately assessing changes the ecosystem service value (ESV) of these mangrove requires more precise distribution data and an appropriate set evaluation methods. In this study, we accurately mapped spatial patterns Guangxi province 2016 2020, using 10 m resolution Sentinel-2 imagery, conducted comprehensive ESV provided by forests. The results showed that (1) from to demonstrated positive development...
Photovoltaic (PV)-driven electrocatalytic CO₂ reduction enables solar energy storage and green fuel production, but PV fluctuations cause instability, impacting product selectivity system stability. To tackle this challenge, we propose...
Patients exhibiting a humoral immune response to the transplanted organ are at increased risk of antibody-mediated rejection and development transplant vasculopathy. Historically, antibodies were thought elicit through complement mediated damage endothelium graft. More recently, studies from our laboratory others have shown that antibody ligation class I molecules on surface endothelial cells transduces signals resulting in functional changes including expression cell survival proteins...
Alloantibodies are a significant barrier to successful transplantation. While desensitization has emerged, efficacy is limited. Interleukin-6 (IL-6) an important mediator of inflammation and immune cell activation. Persistent IL-6 production increases the risk for alloantibody production. Here we report our experience with clazakizumab (anti-IL-6) highly HLA-sensitized patients (HS). From March 2018 September 2020, 20 HS were enrolled in open label pilot study assess safety limited...
Ligation of class I molecules by anti-HLA Ab stimulates an intracellular signaling cascade resulting in endothelial cell (EC) survival and proliferation, has been implicated the process chronic allograft rejection transplant-associated vasculopathy. In this study, we used small interfering RNA blockade focal adhesion kinase (FAK) protein to determine its role I-mediated organization actin cytoskeleton, survival, proliferation primary cultures human aortic EC. Knockdown FAK appreciably...
Treatment options for antibody-mediated rejection (AMR) are limited. Recent studies have shown that inhibition of interleukin-6 (IL-6)/interleukin-6 receptor (IL-6R) signaling can reduce inflammation and slow AMR progression.We report our experience using monthly tocilizumab (anti-IL6R) in 25 pediatric renal transplant recipients with AMR, refractory to IVIg/Rituximab. From January 2013 June 2019, a median (IQR) 12 (6.019.0) doses were given per patient. Serial assessments function, biopsy...
The highly dispersed "single-atom (SA)" catalysts on oxide supports significantly alter the catalytic reaction activity and selectivity meanwhile save catalyst utilization. However, preparation of SA remains a challenge up to now. An approach effectively evaluating stability is required. Herein, density functional theory (DFT)-based first-principles calculations were performed evaluate photocatalytic hydrogen evolution (HER) noble metal (NM = Ag, Au, Pd, Pt) SAs loaded TiO2 support. chemical...