A5041813566- Cytomegalovirus and herpesvirus research
- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Parvovirus B19 Infection Studies
- Diabetes and associated disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Herpesvirus Infections and Treatments
- Immune Cell Function and Interaction
- Muscle Physiology and Disorders
- Electrochemical sensors and biosensors
- HIV Research and Treatment
- Antimicrobial Resistance in Staphylococcus
- HIV/AIDS drug development and treatment
- Polyomavirus and related diseases
- T-cell and B-cell Immunology
- Antibiotic Resistance in Bacteria
- Immunodeficiency and Autoimmune Disorders
- Analytical Chemistry and Sensors
- Tryptophan and brain disorders
- Antibiotics Pharmacokinetics and Efficacy
- Biosimilars and Bioanalytical Methods
- Urinary Tract Infections Management
- Alzheimer's disease research and treatments
- Cerebrospinal fluid and hydrocephalus
- Chromatography in Natural Products
Uppsala University
2011-2024
Sahlgrenska University Hospital
2017-2023
University of Gothenburg
2017-2023
Drottning Silvias barn- och ungdomssjukhus
2019
Uppsala University Hospital
1994-2014
Karlstad Central Hospital
2013
AstraZeneca (Sweden)
1981-1997
The University of Melbourne
1985
Recordings of multiunit sympathetic activity were made in muscle branches the peroneal nerve 22 healthy subjects at rest recumbent position. Nerve was quantitated terms burst incidence (number pulse synchronous bursts per 100 heart beats or min). In a separate session, 4–45 months later, blood drawn from an antecubital vein for noradrenaline analysis. Both and plasma concentrations varied widely between both parameters increased with age. There significant positive correlation subject's...
Donor-specific antibodies create an immunologic barrier to transplantation. Current therapies modify donor-specific are limited and ineffective in the most highly HLA-sensitized patients. The IgG-degrading enzyme derived from Streptococcus pyogenes (IdeS), endopeptidase, cleaves human IgG into F(ab')2 Fc fragments inhibiting complement-dependent cytotoxicity antibody-dependent cellular cytotoxicity, which suggests that IdeS might be useful for desensitization. We report on combined...
Background. Cytomegalovirus (CMV) is a ubiquitous herpesvirus that infects 50–90% of individuals in different populations. After primary infection, the virus persists latently myeloid cells under control specific T-cells. Reactivation CMV infection may cause lethal organ dysfunction and frequently seen immunosuppressed individuals. CD8+ cytotoxic T-cells (CTL) have role suppressing reactivation, dominating CTL response directed against pp65. Methods. MHC tetramers, is, complexes between HLA...
Alzheimer's disease (AD) has been associated with increased local inflammation in the affected brain regions, and some studies also elevated levels of proinflammatory cytokines peripheral blood. Cytomegalovirus (CMV) is known to promote a more effector-oriented phenotype T-cell compartment, increasing age. The aim this study was investigate inflammatory response blood mononuclear cells (PBMCs) from AD patients non-demented (ND) controls. Using multiplex Luminex xMAP assay targeting GM-CSF,...
ABSTRACT Dorsal (PDA) and ventral aortic blood pressure (PVA) heart rate (HR) were measured in conscious resting cod, Gadus morhua L., which has been allowed 24 h recovery from surgery. Plasma adrenalin nonadrenalin concentrations these fish 3·4 2·2 nmol 1−1 respectively, thus lower than previously reported values partially recovered cod. Twenty-four hours after treatment with the adrenergic neurone blocking agent bretylium, PDA was significantly reduced by 17 % compared to sham-injected...
Purpose: The aim of this study was to explore and generate an understanding the meaning physical exercise in lives individuals with Parkinson's disease (PD) participating program. Method: A qualitative design, using Grounded Theory methodology, used. Eleven diagnosed PD were interviewed. Results: core category "Keep moving retain healthy self" identified continuing process maintaining functions activities individuals' lives, which a major contribution. Two categories, "Having explicit life...
Cytomegalovirus (CMV) infection is still the leading opportunistic following solid organ transplantation. The aim of this prospective study renal transplant recipients was to evaluate dynamics CMV-specific T-cells, viral load, and clinical symptoms CMV infection.Levels tetramer-selected CD8(+) T-cells (TetraCD8), interferon-gamma producing (IFNgammaCD8), CD4(+) (IFNgammaCD4), measured using major histocompatibility complex-tetramer cytokine flow cytometry techniques, DNA were monitored...
During an outbreak of extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae at our hospital, we performed educational antibiotic intervention aimed reducing prescriptions second- and third-generation cephalosporins preventing increased use fluoroquinolones carbapenems. In this report, describe the implementation strategy used evaluate effect according to Cochrane recommendations. New recommendations for empirical intravenous treatment were communicated prescribers throughout...
ABSTRACT A duplex quantitative real-time PCR (qPCR) assay was designed to detect both the polymerase gene ( pol ) and glycoprotein gB of cytomegalovirus (CMV). The detection limit qPCR determined be 1 3 copies/reaction linear measure interval 10 8 copies/ml. system compared COBAS Amplicor CMV Monitor test (COBAS) by an analysis 138 plasma samples. Both systems detected in 71 cases had negative results for 33 In addition, 34 samples were positive assay, but no case result negative. Thus, 48%...
Human herpesviruses have previously been implicated in the pathogenesis of Alzheimer's disease (AD) but whether they are causal, facilitating, or confounding factors is yet to be established. A total 50 AD subjects and 52 non-demented (ND) controls were analyzed a multiplex assay for IgG reactivity toward herpes simplex virus (HSV), varicella zoster (VZV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6). The HHV-6 was significantly lower compared ND controls, whereas there no differences...
BK-virus (BKV) associated nephropathy (BKVAN) and BKV haemorrhagic cystitis (HC) are complications of infection/reactivation in renal allogeneic haematopoietic stem cell transplantation (HSCT) patients, respectively. The task how to manage these diseases was given the chair by Swedish Reference Group for Antiviral Therapy (RAV). After individual contributions members working group, consensus discussions were held a meeting on 23 January 2018 arranged RAV. Thereafter, recommendations...
Objective Investigate the performance of real-time 16S PCR and third-generation sequencing in diagnosis external ventricular drain related infections (EVDRI).
Cytomegalovirus (CMV) has been suggested as a contributing force behind the impaired immune responsiveness in elderly, with decreased numbers of naïve T-cells and an increased proportion effector T-cells. Immunological impairment is also implicated part pathogenesis Alzheimer's disease (AD). The aim this study was to investigate whether AD patients present different CMV-specific CD8 profile compared non-demented controls. Blood samples from 50 age-matched controls were analysed for HLA-type,...
Purpose: The purpose of this study was to evaluate whether treatment boys with Duchenne muscular dystrophy using hand orthoses could benefit joint mobility, grip strength, or fine motor function.Method: Eight were provided individually customised rest orthoses. results analysed single-subject design. included a baseline and an intervention phase. A follow-up examination also performed.Results: Boys less than 50° passive wrist extension mobility included. Wrist the dominant increased in four...
Objective: It is assumed that cytomegaloviral (CMV) infection in inflammatory bowel disease (IBD) caused by reactivation due to the immunosuppressive therapy, but role of CMV as a pathophysiological factor and prognostic marker IBD unclear. The aim this study was investigate IBD, with real-time polymerase chain reaction (PCR) immunohistochemistry, emphasis on newly diagnosed disease.Materials methods: In prospective, controlled study, 67 patients 34 control irritable syndrome (IBS) or rectal...
Reports of outbreaks Pneumocystis carinii pneumonia (PCP) among human immunodeficiency virus-negative immunocompromised patients have suggested a person-to-person transmission P. carinii. In this study, 17 bronchoalveolar lavage isolates from in 3 PCP were genotyped, 2 renal transplant recipients and 1 outbreak with haematological disorders. Genotypes the sp. f. hominis (P. f.sp. hominis) mt large subunit ribosomal RNA site 85 detected by methods: direct sequencing different allele-specific...