A5035180352- Renal Transplantation Outcomes and Treatments
- Pancreatic function and diabetes
- Diabetes Management and Research
- Organ Transplantation Techniques and Outcomes
- Diabetes and associated disorders
- Renal Diseases and Glomerulopathies
- COVID-19 Clinical Research Studies
- Transplantation: Methods and Outcomes
- SARS-CoV-2 and COVID-19 Research
- Polyomavirus and related diseases
- Cannabis and Cannabinoid Research
- Long-Term Effects of COVID-19
- Pancreatic and Hepatic Oncology Research
- Neurological Complications and Syndromes
- Pharmacological Effects and Toxicity Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Hepatitis C virus research
- Multiple Myeloma Research and Treatments
- Mechanical Circulatory Support Devices
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Influenza Virus Research Studies
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Cardiac Structural Anomalies and Repair
Sahlgrenska University Hospital
2011-2024
University of Gothenburg
2003-2024
RELX Group (United States)
2020
Helsinki University Hospital
2004
Uppsala University Hospital
2004
Karolinska University Hospital
2004
There are strong indications that only a small fraction of grafts successfully engraft in clinical islet transplantation. One explanation may be the instant blood-mediated inflammatory reaction (IBMIR) elicited by tissue factor, which is produced endocrine cells. In present study, we show islets intended for transplantation produce factor both transmembrane and alternatively spliced form membrane-bound released as microparticles often associated with insulin glucagon granules. A...
In clinical islet transplantation, the instant blood-mediated inflammatory reaction (IBMIR) is a major factor contributing to poor initial engraftment of islets. This triggered by tissue and monocyte chemoattractant protein (MCP)-1, expressed transplanted pancreatic islets when come in contact with blood portal vein. All currently identified systemic inhibitors IBMIR are associated significantly increased risk bleeding or other side effects. To avoid treatment, aim present study was render...
The procedure of human islet isolation needs further optimization and standardization. Here, we describe techniques to enhance enzymatic digestion minimize mechanical forces during the process. protocol has also been modified meet current GMP (cGMP) standards. Moreover, impact donor- process-related factors was correlated use islets for clinical transplantation.One hundred twelve standardized consecutive isolations were evaluated. Metyltioninklorid indermil (topical tissue adhesive) applied...
The fate of islets in clinical transplantation is unclear. To elude on this positron emission tomography combined with computed (PET/CT) was performed for 60 min during islet five patients receiving six transplants. A fraction the (23%) were labeled 18F-fluorodeoxyglucose ([(18)F]FDG) and carefully mixed unlabeled just prior to intraportal transplantation. peak radioactivity concentration liver found at 19 after start infusion corresponded only 75% what expected, indicating that are lost...
Abstract Background Chronic active antibody-mediated rejection (caAMR) in kidney transplants is associated with irreversible tissue damage and a leading cause of graft loss the long-term. However, treatment for caAMR remains challenge to date. Recently, tocilizumab, recombinant humanized monoclonal antibody directed against human interleukin-6 (IL-6) receptor, has shown promise caAMR. it not been systematically investigated so far underscoring need randomized controlled studies this area....
To investigate whether measured glomerular filtration rate (mGFR) is a risk factor for death and/or end-stage renal disease (ESRD) after heart transplantation (HTx).All adult patients (n = 416) who underwent HTx between 1988 and 2010 were included. mGFR was performed both preoperatively postoperatively as annual follow-up. Eight received concomitant kidney transplant (KTx), 15 late KTx due to chronic failure HTx.The mean drop in compared with the preoperative value 12% during first year HTx....
Solid organ transplant (SOT) recipients may be more vulnerable to coronavirus disease 2019 (COVID-19). Data on the clinical course of COVID-19 in immunosuppressed patients are limited, and optimal management strategy for these is yet unclear.We present 53 SOT (31 kidney recipients, 8 liver 5 heart lung 3 liver-kidney 1 kidney-after-heart recipient), transplanted at a Swedish high-volume center each diagnosed with between February 21, 2020 June 22, 2020. Demographic, clinical, treatment data...
Background. Islet-produced tissue factor (TF) triggers an adverse clotting reaction, the instant blood-mediated inflammatory reaction (IBMIR), providing a likely explanation for need of from multiple donors in clinical islet transplantation. In this study, authors investigated whether compounds previously shown to affect TF and macrophage chemoattractant protein (MCP)-1 expression monocytes endothelial cells have same effect human cells. Methods. Islets were cultured presence l-arginine,...
Wilson's disease presenting as acute liver failure (ALF) is potentially fatal, and transplantation (LTx) the only option. We report two patients with ALF treated Molecular Adsorbents Recirculating System (MARS). Both fulfilled criteria for poor prognosis. Because LTx was not available immediately in either case, MARS used a bridge to LTx. In Case 1, serum bilirubin decreased from 803 425 micromol/L after 3 treatments, but increased 656 during break, decreasing again 457 further treatment....
Background. Shipment of pancreata between distant centers is frequently associated with prolonged cold ischemia time (CIT) that leads to poorer outcomes for islet transplantation. Clinical pilot trials have indicated oxygenation explanted human utilizing the two-layer method (TLM) allows use marginal donor The present study aimed clarify whether TLM enhances ischemic tolerance pancreata. Methods. We analyzed retrospectively outcome 200 isolations performed after preservation or storage in...
Increased COVID-19-related morbidity and mortality have been reported in solid organ transplant recipients (SOTRs). Most studies are underpowered for rigorous matching. We report infections, hospitalization, ICU care, from COVID-19, pertinent vaccination data Swedish SOTRs 2020–2021. conducted a nationwide cohort study, encompassing all residents. were identified with ICD-10 codes immunosuppressant prescriptions. Comparison cohorts weighted based on propensity score built potential...
For more than a decade Liberase HI was commonly used as the standard enzyme blend for clinical human islet isolation until enforced replacement by collagenase NB1 (NB1). This change resulted initially in reduction outcome and transplant activities worldwide. retrospective study initiated to compare efficiency of premium grade with 197 isolations. All pancreata were processed between January 2006 June 2008 utilizing same procedures quality assessment except administration preselected lots...
In organ transplanted patients, impaired renal function is of major prognostic importance and influences therapeutic decisions. Therefore, monitoring with glomerular filtration rate (GFR) importance, both before after heart transplantation (HTx). The GFR can be measured directly (mGFR) or estimated (eGFR) equations based on circulating creatinine cystatin C levels. However, these have not been thoroughly validated in the HTx population.We investigated correlation, agreement accuracy between...
Objective. With improvements in long-term results after liver transplantation, chronic kidney disease (CKD) has become a highly relevant problem. The early measurement of the glomerular filtration rate (GFR) can identify those patients who are at risk developing CKD years transplantation. aims this study were to describe prevalence 5 correlation between measured GFR transplantation and late renal function Material methods. A total 152 least post-liver studied. Measured with Chromium EDTA or...
BK-virus (BKV) associated nephropathy (BKVAN) and BKV haemorrhagic cystitis (HC) are complications of infection/reactivation in renal allogeneic haematopoietic stem cell transplantation (HSCT) patients, respectively. The task how to manage these diseases was given the chair by Swedish Reference Group for Antiviral Therapy (RAV). After individual contributions members working group, consensus discussions were held a meeting on 23 January 2018 arranged RAV. Thereafter, recommendations...
Solid organ transplant recipients (SOTRs) are on lifelong immunosuppression, which may interfere with adaptive immunity to COVID-19. The data dynamics and duration of antibody response in SOTRs limited. This longitudinal study examined the longevity both anti-spike (S)- anti-nucleocapsid (N)-specific IgG antibodies after COVID-19 compared matched immunocompetent persons. (n = 65) were controls for disease severity, age, sex order priority. Serum-IgG against N S antigens SARS-CoV-2 analyzed....
The ability to predict clinical function of a specific islet batch released for transplantation using standardized variables remains an elusive goal.Analysis 10 donor, 7 isolation, 3 quality control, and 6 recipient was undertaken in 110 islet-after-kidney transplants correlated the pre- 28-day posttransplant change C-peptide glucose creatinine ratio (ΔCP/GCr).Univariate analysis yielded volume transplanted (Spearman r=0.360, P<0.001) increment insulin secretion (r=0.377, as positively...