A5062521933- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Medical Imaging Techniques and Applications
- Mathematical Biology Tumor Growth
- Peptidase Inhibition and Analysis
- Brain Metastases and Treatment
- Multiple Myeloma Research and Treatments
- Functional Brain Connectivity Studies
- Monoclonal and Polyclonal Antibodies Research
- Lanthanide and Transition Metal Complexes
- Cancer-related cognitive impairment studies
- Medical Imaging and Pathology Studies
- Meningioma and schwannoma management
- Neural Networks and Applications
- Electron Spin Resonance Studies
- Calcium signaling and nucleotide metabolism
- Facial Nerve Paralysis Treatment and Research
- Circular RNAs in diseases
- Iron oxide chemistry and applications
- Fetal and Pediatric Neurological Disorders
- Characterization and Applications of Magnetic Nanoparticles
- Management of metastatic bone disease
University of California, Los Angeles
2020-2025
Samueli Institute
2021-2025
Washington University in St. Louis
2017-2025
Resonance Research (United States)
2024
UCLA Health
2024
Brown University
2024
Memorial Sloan Kettering Cancer Center
2017-2023
Cooper University Hospital
2022
University of Illinois Urbana-Champaign
2018
Multiple myeloma (MM) is a plasma B-cell hematologic cancer that causes significant skeletal morbidity. Despite improvements in survival, heterogeneity response remains major challenge MM. Cluster of differentiation 38 (CD38) type II transmembrane glycoprotein overexpressed cells and implicated MM cell signaling. Daratumumab U.S. Food Drug Administration–approved high-affinity monoclonal antibody targeting CD38 clinically benefiting refractory patients. Here, we evaluated...
The T2-FLAIR mismatch sign on MR imaging is a highly specific biomarker of isocitrate dehydrogenase (
Understanding the mechanisms driving specific and nonspecific tissue uptake of antibodies can inform protein engineering strategies that maximize therapeutic efficacy in target tissues while minimizing off-target toxicities. While vitro cell assays are typically used to study these internalization mechanisms, there few methods readily available evaluate pathways vivo. Single photon emission computed tomography (SPECT) imaging with a non-residualizing radiohalogen probe measure total levels...
Abstract The universalizability of the metric percentage signal recovery (PSR) derived from dynamic susceptibility contrast (DSC) perfusion MRI is limited by its dependency acquisition parameters. In this technical assessment, we tested different reference tissues for PSR normalization and found normal-appearing white matter (NAWM) to have least inter-patient variability when using a fixed PSR-optimized protocol. A logarithmic NAWM improved consistency values cohort brain tumor patients was...
Abstract Background MRI-derived apparent diffusion coefficient (ADC) and contrast-enhancement (CE) may represent non-invasive biomarkers to evaluate microstructural tissue changes histopathological immune cell infiltration induced by checkpoint inhibitors (ICI). Methods 125 lesions across 93 patients were analyzed. ADC (reflecting water diffusivity) CE T1-subtraction maps blood-brain barrier permeability) tumor values used for bivariate histograms of CE, quantify voxel fractions belonging...
To determine the feasibility and biologic correlations of dynamic susceptibility contrast (DSC), enhanced (DCE), quantitative maps derived from leakage effects obtained simultaneously in gliomas using spin-and-gradient-echo echoplanar imaging (dynamic SAGE-EPI) during a single injection.
OBJECTIVES: Deep sedation in the emergency department (ED) is common, increases deep ICU, and negatively associated with outcome. Limiting ED may, therefore, be a high-yield intervention to improve However, feasibility of conducting an adequately powered ED-based clinical trial unknown. Our objectives were assess terms of: 1) recruitment, 2) protocol implementation practice change, 3) safety. Patient-centered outcomes assessed better plan for future large-scale trial. DESIGN: Pragmatic,...
Multiple myeloma (MM) is a cancer of bone marrow (BM) plasma cells, which increasingly treatable but still incurable. In 90% MM patients, severe osteolysis results from pathological interactions between cells and the microenvironment. Delineating specific molecules pathways for their role in supportive BM vital developing new therapies. Very Late Antigen 4 (VLA4, integrin α4β1) key player cell-cell adhesion signaling cells. We evaluated VLA4 selective near infrared fluorescent probe,...
Normalized relative cerebral blood volume (nrCBV) and percentage of signal recovery (PSR) computed from dynamic susceptibility contrast (DSC) perfusion imaging are useful biomarkers for differential diagnosis treatment response assessment in brain tumors. However, their measurements dependent on DSC acquisition factors, CBV-optimized protocols technically differ PSR-optimized protocols. This study aimed to generate "synthetic" data with adjustable synthetic parameters using dual-echo...
Abstract Purpose There is limited knowledge about the associations between sodium and proton MRI measurements in brain tumors. The purpose of this study was to quantify intra- intertumoral correlations sodium, diffusion, perfusion human gliomas. Methods Twenty glioma patients were prospectively studied on a 3T system with multinuclear capabilities. Three mutually exclusive tumor volumes interest (VOIs) segmented: contrast-enhancing (CET), T2/FLAIR hyperintense non-enhancing (NET), necrosis....
Abstract Background Diffusion MRI estimates of the apparent diffusion coefficient (ADC) have been shown to be useful in predicting treatment response patients with glioblastoma (GBM), ADC elevations indicating tumor cell death. We aimed investigate whether values measured before and after immune checkpoint inhibitors (ICIs) changes these could predict overall survival (OS) recurrent IDH wild-type GBM. Methods Forty-four who met following inclusion criteria were included this retrospective...
Amine-weighted chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) is particularly valuable as an amine- and pH-sensitive technique in brain tumors, targeting the intrinsically high concentration of amino acids with exchangeable amine protons reduced extracellular pH tumors. CEST MRI contrast dependent on glioma genotype, likely related to differences degree malignancy metabolic behavior. may provide complementary value anatomic conventional exploratory therapies...
Abstract Purpose There remains no consensus normal-appearing white matter (NAWM) normalization method to compute normalized relative cerebral blood volume (nrCBV) and apparent diffusion coefficient (nADC) in brain tumors. This reader study explored nrCBV nADC differences using different NAWM methods. Methods Thirty-five newly diagnosed glioma patients were studied. For each patient, two readers created four regions of interests: (1) a single plane the centrum semiovale (CSOp), (2) 3 spheres...
The objective of this study was to identify baseline clinical and radiological characteristics brain metastases (BMs) associated with a higher probability lesion-specific progression-free survival (PFS-L) after laser interstitial thermal therapy (LITT).
Abstract Background Given the invasive nature of glioblastoma, tumor cells exist beyond contrast-enhancing (CE) region targeted during treatment. However, areas non-enhancing (NE) tumors are difficult to visualize and delineate from edematous tissue. Amine chemical exchange saturation transfer echo planar imaging (CEST-EPI) is a pH-sensitive molecular magnetic resonance technique that was evaluated in its ability identify infiltrating NE prognosticate survival. Methods In this prospective...
Abstract Typical longitudinal radiographic assessment of brain tumors relies on side-by-side qualitative visualization serial magnetic resonance images (MRIs) aided by quantitative measurements tumor size. However, when assessing slowly growing and/or complex tumors, and quantification may be difficult or unreliable. Whole-brain, patient-specific “digital flipbooks” scans are a potential method to augment reads in clinical settings enhancing the visual perception changes size, mass effect,...
Abstract BACKGROUND Sodium neuroimaging is a promising technique for diagnosing and monitoring brain tumors, providing insights into microenvironment metabolism. However, at 3T, it limited by low signal-to-noise ratio resolution, resulting in long acquisition times low-quality images. To address these limitations, we developed physics-informed generative adversarial network (GAN) approach high-resolution sodium of tumors 3T. METHODS 5,078 anatomical sequences from 1,330 tumor patients...
Abstract Background Alterations in tumor growth rate (TGR) recurrent glioblastoma (rGBM) after treatment may be useful for identifying therapeutic activity. The aim of this study was to assess the impact volumetric TGR alterations on overall survival (OS) rGBM treated with chemotherapy or without radiation therapy (RT). Methods Sixty-one patients concomitant (RT) at 1st 2nd recurrence were retrospectively examined. Pre- and post-treatment contrast enhancing volumes computed. Patients...
As treatments for diffuse gliomas have advanced, survival patients with has also increased. However, there remains limited knowledge on the relationships between brain connectivity and lasting changes to cognitive function that glioma survivors often experience long after completing treatment. This resting-state functional magnetic resonance imaging (rs-fMRI) study explored (FC) alterations associated in of gliomas. In this pilot study, 22 (mean age 43.8 ± 11.9) who completed treatment...
Inhibition of the isocitrate dehydrogenase (IDH)-mutant enzyme is a novel therapeutic target in IDH-mutant gliomas. Imaging biomarkers IDH inhibitor treatment efficacy human gliomas are largely unknown. This study investigated early volumetric, perfusion, and diffusion MRI changes IDH1-mutant during treatment.Twenty-nine glioma patients who received obtained anatomical, pretreatment at 3-6 weeks (n = 23) and/or 2-4 months 14) were retrospectively studied. Normalized relative cerebral blood...