A5103198898- Organ Transplantation Techniques and Outcomes
- Sulfur Compounds in Biology
- Organ Donation and Transplantation
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Renal and Vascular Pathologies
- Transplantation: Methods and Outcomes
- Heme Oxygenase-1 and Carbon Monoxide
- Bladder and Urothelial Cancer Treatments
- Innovations in Medical Education
- Alcohol Consumption and Health Effects
- Dialysis and Renal Disease Management
- Diversity and Career in Medicine
- Biomedical Research and Pathophysiology
- Healthcare professionals’ stress and burnout
- Cancer, Hypoxia, and Metabolism
- Surgical Simulation and Training
- Neuroscience of respiration and sleep
- Urinary and Genital Oncology Studies
- Neurological Complications and Syndromes
- Chronic Kidney Disease and Diabetes
- Palliative Care and End-of-Life Issues
- Erythropoietin and Anemia Treatment
- Genetic and Kidney Cyst Diseases
- Vascular anomalies and interventions
Western University
2016-2025
London Health Sciences Centre
2015-2024
Lawson Health Research Institute
2015-2024
Translational Research in Oncology
2024
Ankara Bilkent City Hospital
2024
Bilkent University
2024
St Joseph's Health Care
2017-2022
St. Joseph’s Healthcare Hamilton
2019
University of Manitoba
2016
St. Joseph's Hospital
2015
Ischemia-reperfusion injury is unavoidable during organ transplantation. Prolonged ischemia-reperfusion detrimental to short-term and long-term graft function survival. H2S a recently characterized, endogenously produced gaseous molecule with important physiological roles that has been shown be cytoprotective tissue injury. The current study aimed determine whether could mitigate cold renal in the clinically relevant context of allogeneic transplantation.Following bilateral native...
Ischemia-reperfusion injury is unavoidably caused by loss and subsequent restoration of blood flow during organ procurement, prolonged ischemia-reperfusion IRI results in increased rates delayed graft function early loss. The endogenously produced gasotransmitter, hydrogen sulfide (H2 S), a novel molecule that mitigates hypoxic tissue injury. current study investigates the protective mitochondrial effects H2 S vivo cold storage renal transplantation (RTx) vitro Donor allografts from Brown...
Background. The optimal method of oxygen delivery to donor kidneys during ex vivo machine perfusion has not been established. We have recently reported the beneficial effects subnormothermic (22°C) blood in preservation porcine donation after circulatory death kidneys. Since using as a clinical perfusate limitations, including matching availability and potential presence pathogen, we sought assess hemoglobin-based carrier (HBOC-201) kidney for renal protection. Methods. Pig (n = 5) were...
The incidence of renal cell carcinoma (RCC) continues to rise concurrently with the increased prevalence end-stage disease worldwide. Treatment for small masses be partial nephrectomy mostly involving clamping blood vessels. Although necessary, this technique results in warm ischemia and reperfusion injury (IRI) afflicted kidney. We have recently demonstrated that hydrogen sulfide (H2S), a novel endogenous gaseous molecule, protects against prolonged cold short-term IRI. In current study, we...
Heart transplant has been accepted as the standard treatment for end-stage heart failure. Because of its susceptibility to ischemia–reperfusion injury, can be preserved only 4 6 hours in cold static preservation solutions. Prolonged ischemia time is adversely associated with primary graft function and long-term survival. New strategies preserve donor hearts are urgently needed. We demonstrate that AP39, a mitochondria-targeting hydrogen sulfide donor, significantly increases cardiomyocyte...
Bladder cancer (BCa) is the most common genitourinary malignancy, with a high global incidence and recurrence rate that paired an increasing caregiver burden higher financial cost, in addition to morbidity mortality worldwide. Histologically, BCa categorized into non-muscle invasive, muscle metastatic BCa, on basis of which therapeutic strategy determined. Despite all innovations recent advances research, conventional therapies such as chemotherapy, immunotherapy, radiotherapy, surgery fall...
Background. This study aimed to evaluate the ability of Donation Advisor (DA), a validated clinical decision support tool that uses continuous monitoring, variability analysis, and predictive models, (i) predict likelihood successful donation after circulatory determination death (DCD) before withdrawal life-sustaining measures (WLSM), (ii) describe ischemia during WLSM in DCD patients. Methods. Eligible patients were screened at 5 sites where DA was implemented. reports generated real time...
Background & Objective: Migraine is the third most common disease and second leading cause of neurological disability globally. Alternative treatments are needed due to limitations conventional medications. Virtual reality (VR) shows promise in pain management. This study evaluates efficacy VR technology combined with classical music as an adjunctive treatment for acute migraine emergency department (ED). Methods: In a prospective, non-randomized study, 140 patients migraines at two...
What's known on the subject? and What does study add? Hydrogen sulphide (H 2 S) has recently been classified as a member of family small gaseous molecules called gasotransmitters found to have many important physiological functions. Several recent studies elucidated protective effects H S in models tissue ischaemia–reperfusion injury (IRI), including hepatic, myocardial, pulmonary, cerebral renal IRI. It previously shown that number properties may contribute its protection against IRI,...
Physician burnout is linked to decreased job performance, increased medical errors, interpersonal conflicts and depression. Two recent multispecialty studies showed that urologists had the highest rate of burnout. However, these reports were limited by a low sample size (119). We aimed establish prevalence urologist associated factors.In 2016 American Urological Association Census, Maslach Burnout Inventory questions randomly assigned half respondents. Using matrix sampling, 1,126 practicing...
In Brief Background Carbon monoxide (CO) inhalation protects organ by reducing inflammation and cell death during transplantation processes in animal model. However, using CO clinical is difficult due to its delivery a controlled manner. A manganese-containing releasing molecules (CORM)-401 has recently been synthesized which can efficiently deliver 3 molar equivalents of CO. We report the ability this anti-inflammatory CORM-401 reduce ischemia reperfusion injury associated with prolonged...
Cold ischemia-reperfusion injury (IRI) is an inevitable event that increases post-transplant complications. We have previously demonstrated supplementation of University Wisconsin (UW) solution with non-FDA-approved hydrogen sulfide (H2S) donor molecules minimizes cold IRI and improves renal graft function after transplantation. The present study investigates whether FDA-approved H2S molecule, sodium thiosulfate (STS), will the same or superior effect in a clinically relevant rat model...
Recurrence of focal segmental glomerular sclerosis (FSGS) in the allograft following renal transplantation can be graft threatening. To assess risk factors associated with FSGS recurrence, we analyzed 22 patients who underwent between 1996 and 2004. Five (Group I, 23%) developed post-transplantation. Of these patients, 60% had undergone bilateral nephrectomy (BN) for progressive disease compared none that were free recurrence II) (p = 0.0006). Other linked recurrent time to first dialysis I:...
Chronic obstructive uropathy can cause irreversible kidney injury, atrophy and inflammation, which ultimately lead to fibrosis. Epithelial-mesenchymal transition is a key trigger of fibrosis that caused by up-regulation TGF-β1 (transforming growth factor-β1) ANGII (angiotensin II). H2S an endogenously produced gasotransmitter with cytoprotective properties. We sought elucidate the effects slow-releasing donor GYY4137 on chronic ureteral obstruction evaluate potential mechanisms.Following...