A5102947082- Spinal Fractures and Fixation Techniques
- Medical Imaging and Analysis
- Spinal Cord Injury Research
- Cervical and Thoracic Myelopathy
- Infectious Diseases and Tuberculosis
- Head and Neck Surgical Oncology
- Kawasaki Disease and Coronary Complications
- Diabetic Foot Ulcer Assessment and Management
- Autophagy in Disease and Therapy
- Orthopedic Infections and Treatments
- Bone Tissue Engineering Materials
- Autoimmune and Inflammatory Disorders Research
- Spinal Dysraphism and Malformations
- Orthopaedic implants and arthroplasty
- Inflammasome and immune disorders
- Spine and Intervertebral Disc Pathology
- Bone and Joint Diseases
- Diagnosis and treatment of tuberculosis
- Nerve injury and regeneration
- Polymer Surface Interaction Studies
- Pelvic and Acetabular Injuries
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2006-2025
Wenzhou Medical University
2004-2025
After spinal cord injury, programmed cell death is common. In this context, autophagy plays a crucial role in clearing cellular debris, while necroptosis exacerbates neuroinflammation and further damages neural structures. The neuroprotective drug davunetide has shown substantial therapeutic effects on brain diseases, but its treating injury remains unclear. Therefore, the aim of study was to investigate after injury. To do this, we established mouse model contusion administered intranasally...
Abstract Spinal cord injury (SCI) is a serious that can lead to irreversible motor dysfunction. Due its complicated pathogenic mechanism, there are no effective drug treatments. Piperine, natural active alkaloid extracted from black pepper, has been reported influence neurogenesis and exert neuroprotective effect in traumatic brain injury. The aim of this study was investigate the therapeutic piperine an SCI model. induced mice by clamping spinal with vascular clip for 1 min. Before every 2...
Abstract There is no effective strategy for the treatment of spinal cord injury (SCI), a devastating condition characterized by severe hypoxia and ischemic insults. In this study, we investigated histology pathophysiology SCI milieu in rat model found that areas were unevenly interspersed compressed SCI. With new knowledge, generated embryonic neural stem cells (NSCs) expressing basic fibroblast growth factor (bFGF) under regulation five hypoxia-responsive elements (5HRE) using lentiviral...
Objective To discuss the clinical characteristics and treatment of upper cervical spine injuries in elderly. Methods A retrospective study was done on data 28 elderly patients ( > 60 years old) with treated from January 2003 to December 2007. There were 20 males 8 females, at age range 60-86 (mean 68.1 years). Injury causes included slip 16 patients, traffic injury eight fall height four. Atlas fractures occurred five axis ones 15,of which there odontoid fractures, six C2 vertebral arch one...
Objective To explore the strategy of minimally invasive surgery for different types thoracolumbar fractures. Methods Retrospectively reviewing 220 cases fractures from February 1997 to October 2007. All patients, including 153 males and 67 females, with an average 36.8 years old (range, 18-66 years), underwent surgery. According Gertzbein fracture classification, 185 belonged type A, 26 B, 9 C. load-sharing score, 62 were 4 scores, 48 5, 13 6, 21 7, 43 8 33 9. Of 123 patients treated...
Abstract Background: Spinal cord injury (SCI) is a serious that can lead to irreversible motor dysfunction and subsequently result in disability even death. Due its complicated pathogenic mechanism, there are no effective drug treatments. Piperine, natural active alkaloid extracted from black pepper, suppressed inflammation previous study. The aim of this study was investigate the therapeutic effect piperine spinal model. Methods: induced C57BL/6 mice by clamping with vascular clip (15 g...
Background: Spinal cord injury (SCI) is a serious that can lead to irreversible motor dysfunction and subsequently result in disability even death. Due its complicated pathogenic mechanism, there are no effective drug treatments. Piperine, natural active alkaloid extracted from black pepper, suppressed inflammation previous study. The aim of this study was investigate the therapeutic effect piperine SCI model.Methods: induced C57BL/6 mice by clamping spinal with vascular clip for 1 min....