A5078759209- Pregnancy and preeclampsia studies
- Congenital heart defects research
- Cardiovascular Function and Risk Factors
- Diabetes Management and Research
- Birth, Development, and Health
- Single-cell and spatial transcriptomics
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- RNA modifications and cancer
- Angiogenesis and VEGF in Cancer
- Diabetes Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Reproductive System and Pregnancy
- Cancer Genomics and Diagnostics
- Ion channel regulation and function
- Lipid metabolism and biosynthesis
- Gestational Diabetes Research and Management
- Retinoids in leukemia and cellular processes
- Prenatal Screening and Diagnostics
- Metabolism, Diabetes, and Cancer
- Virus-based gene therapy research
- Axon Guidance and Neuronal Signaling
- Diet and metabolism studies
- Pluripotent Stem Cells Research
- Sirtuins and Resveratrol in Medicine
- Cell Image Analysis Techniques
The University of Queensland
2014-2025
SUMMARY Heart disease is the leading cause of morbidity and mortality in individuals with diabetes, due largely to risks associated ischaemic injuries such as myocardial infarction (MI). We use human population genetic data demonstrate that current biomarkers hyperglycaemia do not account for risk post-MI diabetes patients. This study therefore systematically evaluates glycaemic stress underpinning cardiovascular diabetes. Using vivo vitro models, we variability rather than alone a dominant...
Abstract Pluripotent stem cells provide a scalable approach to analyse molecular regulation of cell differentiation across developmental lineages. Here, we engineer barcoded induced pluripotent generate an atlas multilineage from pluripotency, encompassing eight-day time course with modulation WNT, BMP, and VEGF signalling pathways. Annotation in vitro types reference vivo development reveals diverse mesendoderm lineage including lateral plate paraxial mesoderm, neural crest, primitive gut....
<title>Abstract</title> Heart disease is the leading cause of morbidity and mortality in individuals with diabetes, due largely to risks associated ischaemic injuries such as myocardial infarction (MI). We use human population genetic data demonstrate that current biomarkers hyperglycaemia do not account for risk post-MI diabetes patients. This study therefore systematically evaluates glycaemic stress underpinning cardiovascular diabetes. Using <italic>in vivo</italic> vitro</italic> models,...
Journal Article Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of infarction Get access Meredith A Redd, Redd Institute for Molecular Bioscience, University Queensland, 306 Carmody Road, St.Lucia, QLD 4072, AustraliaCritical Care Research Group, The Prince Charles Hospital Northside Clinical Unit and Faculty Medicine, Australia Search other works by this author on: Oxford Academic PubMed Google Scholar Yusuke Yoshikawa, Yoshikawa School Biomedical Sciences,...
Abstract Fetal growth and survival is dependent on the elaboration propinquity of fetal maternal circulations within placenta. Central to this formation interhaemal membrane, a multi-cellular lamina facilitating exchange oxygen, nutrients metabolic waste products between mother fetus. In rodents, cellular barrier contains two transporting layers syncytiotrophoblast, which are multinucleated cells that form by cell-cell fusion. Previously, we reported expression GPI-linked cell surface...
The Coxsackie virus and adenovirus receptor (CXADR) is an adhesion molecule known for its role in virus-cell interactions, epithelial integrity, organogenesis. Loss of Cxadr causes numerous embryonic defects mice, notably abnormal development the cardiovascular system, lethality. While CXADR expression has been reported placenta, precise cellular localization function within this tissue are unknown. Since impairments placental can cause secondary abnormalities, a phenomenon referred to as...
SUMMARY Pluripotent stem cells provide a scalable approach to analyse molecular regulation of cell differentiation across multiple developmental lineage trajectories. In this study, we engineered barcoded iPSCs generate an atlas multilineage from pluripotency, encompassing time-course WNT-induced perturbed using modulators WNT, BMP, and VEGF signalling. Computational mapping in vitro types vivo lineages revealed diversity iPSC-derived comprising mesendoderm including lateral plate paraxial...
The placental vasculature provides the developing embryo with a circulation to deliver nutrients and dispose of waste products. However, in mouse, vascular components chorio-allantoic placenta have been largely unexplored due lack well-validated molecular markers. This is required study how these blood vessels form development they are impacted by embryonic or maternal defects. Here, we employed marker analysis characterize arterial/arteriole venous/venule endothelial cells (ECs) during...
Abstract Placental vascular gene networks in mammals have been largely unexplored due to a lack of well validated molecular markers identify them. This is required study how they form development, and are impacted by embryonic or maternal defects, which in-turn adversely affects the forming heart vasculature. Such defects known be consequence iron deficiency (ID), most common nutrient world-wide. Here we employed marker analysis characterise arterial/arteriole venous/venule endothelial cells...