A5049883489- Pluripotent Stem Cells Research
- Congenital heart defects research
- Developmental Biology and Gene Regulation
- Animal Genetics and Reproduction
- Reproductive Biology and Fertility
- CRISPR and Genetic Engineering
- Renal and related cancers
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Single-cell and spatial transcriptomics
- Tissue Engineering and Regenerative Medicine
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Hedgehog Signaling Pathway Studies
- Genetics and Neurodevelopmental Disorders
- Cancer-related gene regulation
- Craniofacial Disorders and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Genomics and Chromatin Dynamics
- Wnt/β-catenin signaling in development and cancer
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Cell Image Analysis Techniques
- Pancreatic function and diabetes
- Cleft Lip and Palate Research
- Cell Adhesion Molecules Research
Children's Medical Research Institute
2016-2025
The University of Sydney
2016-2025
Duke University Hospital
2024
Naval Surface Warfare Center
2024
University of Calgary
2017-2022
Westmead Institute
2012-2014
Migration Institute of Australia
2013
University of Hong Kong
1987-2010
Children's Hospital at Westmead
2010
HKU-Pasteur Research Pole
2010
In the mouse, definitive endoderm is derived from epiblast during gastrulation, and, at early organogenesis stage, forms primitive gut tube, which gives rise to digestive tract, liver, pancreas and associated visceral organs. The transcription factors, Sox17 (a Sry-related HMG box factor) its upstream Mixer (homeobox Casanova novel Sox factor), have been shown function as determinants in Xenopus zebrafish, respectively. However, whether mammalian orthologues of these genes are also involved...
Primitive-streak-stage mouse embryos were treated with Mitomycin C injected intraperitoneally into pregnant females at 6.75--7.0 days post coitum. The newborn mice developed poorly and mortality was high during the suckling period. Many weaned survivors showed impaired fertility poor breeding performance. Histological examination revealed a paucity of germ cells in adult gonads. deficiency mainly caused by severe reduction primordial cell population early embryonic life, which not fully...
The prospective fate of cells in the primitive streak was examined at early, mid and late stages mouse gastrula development to determine order allocation mesoderm extraembryonic membranes fetal tissues. At early-streak stage, contribute predominantly tissues as previously found. However, a surprising observation is that erythropoietic precursors yolk sac emerge earlier than bulk vitelline endothelium, which formed continuously throughout development. This may suggest endothelial cell...
ABSTRACT Orthotopic grafts of [3H]thymidine-labelled cells have been used to demonstrate differences in the normal fate tissue located adjacent and different regions primitive streak 8th day mouse embryos developing vitro. The posterior produces predominantly extraembryonic mesoderm, while middle portion gives rise lateral mesoderm anterior region generates mostly paraxial gut notochord. Embryonic ectoderm part contributes mainly neurectoderm. This pattern colonization is similar map...
ABSTRACT The spatial distribution of the cranial paraxial mesoderm and neural crest cells during craniofacial morphogenesis mouse embryo was studied by micromanipulative cell grafting labelling. Results this study show that arising at same segmental position share common destinations. Mesodermal from somitomeres I, III, IV VI were distributed to tissues as forebrain, caudal midbrain, rostral, middle hindbrains found respectively next these mesodermal segments. This finding suggests a basic...
The mouse alpha 1(II) collagen gene has been isolated and a 5' portion of the which low homology to other genes was used study pattern expression during embryogenesis. In situ hybridization studies show that in mouse, like chick, is expressed chondrogenic tissues advance chondrocyte differentiation. early embryogenesis at 9.5 days both cranial mesenchyme destined for chondrocranium, sclerotome somites, 12.5 primordia hyoid laryngeal cartilage. Type II transcripts were found all axial...