A5005311973- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Congenital heart defects research
- Developmental Biology and Gene Regulation
- Estrogen and related hormone effects
- Pluripotent Stem Cells Research
- Animal Genetics and Reproduction
- T-cell and B-cell Immunology
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Glutathione Transferases and Polymorphisms
- Steroid Chemistry and Biochemistry
- Renal and related cancers
- Mass Spectrometry Techniques and Applications
- Reproductive Biology and Fertility
- Epigenetics and DNA Methylation
- Food Allergy and Anaphylaxis Research
- Craniofacial Disorders and Treatments
- Asthma and respiratory diseases
- Atherosclerosis and Cardiovascular Diseases
- Angiogenesis and VEGF in Cancer
- Apelin-related biomedical research
- Cancer Cells and Metastasis
- Fibroblast Growth Factor Research
- Mast cells and histamine
American Xtal Technology (United States)
2019-2020
Children's Medical Research Institute
1997-2003
Institut de génétique et de biologie moléculaire et cellulaire
2001
The University of Sydney
2000
Centenary Institute
1997-2000
St Vincent's Hospital Sydney
1998
UNSW Sydney
1998
The prospective fate of cells in the primitive streak was examined at early, mid and late stages mouse gastrula development to determine order allocation mesoderm extraembryonic membranes fetal tissues. At early-streak stage, contribute predominantly tissues as previously found. However, a surprising observation is that erythropoietic precursors yolk sac emerge earlier than bulk vitelline endothelium, which formed continuously throughout development. This may suggest endothelial cell...
NOD mice develop spontaneous IDDM as a result of T-cell–mediated autoimmune destruction pancreatic β-cells. It is not known why these T-cells become autoreactive, nor it clear whether the breakdown in self-tolerance reflects general problem T-cell development or selective defect an yet undefined regulatory cell population. In this study, we showed that mice, although relatively normal with regard to most thymocyte subsets, exhibit marked deficiency αβTCR+CD4−CD8− (αβ+DN) thymus and, lesser...
ABSTRACT The cardiogenic potency of cells in the epiblast early primitive-streak stage (early PS) embryo was tested by heterotopic transplantation. results this study show that anterior and posterior PS-stage embryos have similar potency, they differentiated to heart after were transplanted directly field late PS embryo. That can acquire a cardiac fate without any prior act ingression through primitive streak or movement within mesoderm suggests neither morphogenetic event is critical for...
An organizer population has been identified in the anterior end of primitive streak mid-streak stage embryo, by expression Hnf3beta, Gsc(lacZ) and Chrd, ability these cells to induce a second neural axis host embryo. This cell can therefore be regarded as mid-gastrula and, together with early-gastrula node, constitute mouse embryo at successive stages development. The profile genetic activity tissue contribution change during gastrulation, suggesting that may populated succession populations...
Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it associated with detrimental patient outcomes. It contains phosphorylated tyrosines which evolutionarily preceded deuterostome gastrulation and tissue differentiation mechanisms.
Inflammation in asthma and other allergic diseases is characterized by excessive production of immunoglobulin E (IgE) the influx leukocytes, especially eosinophils. Interleukin 4 (IL-4) IL-5 are essential for IgE eosinophilia, respectively, produced mast cells conditions, which glucocorticoids widely used therapeutically. We assessed effect on IL-4 mRNA RBL-2H3 cell line, an analog mucosal cells. mRNAs were induced antigen that to cross-link receptor bound IgE, calcium ionophore, or...
Abstract Systemic lupus erythematosus induced by Mycobacterium bovis in diabetes-prone nonobese diabetic mice was mapped a backcross to the BALB/c strain. The subphenotypes—hemolytic anemia, antinuclear autoantibodies, and glomerular immune complex deposition—did not cosegregate, linkage analysis for each trait performed independently. Hemolytic anemia two loci: Bah1 at MHC on chromosome 17 Bah2 distal 16. Antinuclear autoantibodies three Bana1 17, Bana2 10, Bana3 1. Glomerular deposition...
AbstractThe development of techniques for culturing postimplantation mouse embryos has opened up the possibility continuous observation embryonic in vitro. Current methods have supported extensive growth and morphogenesis embryo from stage gastrulation (at approx 6.5 d postcoitum [dpc]) to as far late organogenesis (10.5 dpc). Our capability grow outside confine uterine environment also offered an unique opportunity study through direct microsurgical manipulations, or, short,...
SUMMARY Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it associated with detrimental patient outcomes. It contains phosphorylated tyrosines which evolutionarily preceded deuterostome gastrulation and tissue differentiation mechanisms. Here, we demonstrate that manipulating PGRMC1 phosphorylation status MIA PaCa-2 (MP) cells imposes broad pleiotropic effects. Relative to parental over-expressing hemagglutinin-tagged wild-type (WT) PGRMC1-HA,...
Abstract Background: Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it associated with detrimental patient outcomes. It contains phosphorylated tyrosines which evolutionarily preceded deuterostome gastrulation and tissue differentiation mechanisms. Results: We demonstrate that manipulating PGRMC1 phosphorylation status MIA PaCa-2 (MP) cells imposes broad pleiotropic effects. Relative to parental over-expressing hemagglutinin-tagged wild-type (WT)...
The orientation of the anterior-posterior (A-P) axis was examined in gastrula-stage Hnf3beta, Otx2 and Lim1 null mutant embryos that display defective development. In situ hybridization analysis expression pattern genes associated with posterior germ layer tissues primitive streak (T, Wnt3 Fgf8) anterior endoderm (Cer1 Sox17) revealed A-P remains aligned proximo-distal plane gastrula. Further cells which express Chrd activity are either absent Hnf3beta or localised heterotopic sites mutants....
Abstract Background: Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it associated with detrimental patient outcomes. It contains phosphorylated tyrosines which evolutionarily preceded deuterostome gastrulation and tissue differentiation mechanisms. Results: We demonstrate that manipulating PGRMC1 phosphorylation status MIA PaCa-2 (MP) cells imposes broad pleiotropic effects. Relative to parental over-expressing hemagglutinin-tagged wild-type (WT)...
Abstract Background: Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it associated with detrimental patient outcomes. It contains phosphorylated tyrosines which evolutionarily preceded deuterostome gastrulation and tissue differentiation mechanisms. Results: We demonstrate that manipulating PGRMC1 phosphorylation status MIA PaCa-2 (MP) cells imposes broad pleiotropic effects. Relative to parental over-expressing hemagglutinin-tagged wild-type (WT)...