A5018634675- Wound Healing and Treatments
- Burn Injury Management and Outcomes
- Pressure Ulcer Prevention and Management
- Surgical Sutures and Adhesives
- Dermatologic Treatments and Research
- Planarian Biology and Electrostimulation
- Pediatric Pain Management Techniques
- Forensic Entomology and Diptera Studies
- Chronic Kidney Disease and Diabetes
- Nanoparticles: synthesis and applications
- Acute Kidney Injury Research
- Thermoregulation and physiological responses
- Bee Products Chemical Analysis
- Cell death mechanisms and regulation
- Injury Epidemiology and Prevention
- Caveolin-1 and cellular processes
- Tendon Structure and Treatment
- Spectroscopy Techniques in Biomedical and Chemical Research
- Renal cell carcinoma treatment
- Silk-based biomaterials and applications
- Antimicrobial agents and applications
- Animal testing and alternatives
- Skin Protection and Aging
- Family and Patient Care in Intensive Care Units
- Advanced Fluorescence Microscopy Techniques
Children's Medical Research Institute
2012-2025
Queensland University of Technology
2016-2025
The University of Queensland
2012-2024
Royal Children's Hospital
2007-2024
The University of Western Australia
2021-2024
Griffith University
2002-2024
Queensland Children’s Hospital
2024
Bridge University
2023
Central Queensland University
2023
Murdoch Children's Research Institute
2023
Our group has developed an ovine model of deep dermal, partial-thickness burn where the fetus heals scarlessly and lamb with scar. The comparison collagen structure between these two different mechanisms healing may elucidate process scarless wound healing. Picrosirius staining followed by polarized light microscopy was used to visualize fibers, digital capture analysis. Collagen deposition increased fetal age fibers became thicker, changing from green (type III collagen) yellow/red I...
ABSTRACT Using our porcine model of deep dermal partial thickness burn injury, various cooling techniques (15 °C running water, 2 ice) first aid were applied for 20 minutes compared with a control (ambient temperature). The subdermal temperatures monitored during the treatment and wounds observed photographed weekly 6 weeks, observing reepithelialization, wound surface area cosmetic appearance. Tissue histology scar tensile strength examined weeks after burn. ice treatments decreased...
ABSTRACT This research introduces a novel dressing for burn wounds, containing silver nanoparticles in hydrogels infected care. The 2‐acrylamido‐2‐methylpropane sulfonic acid sodium salt have been prepared via ultraviolet radiation. formation of was monitored by surface plasmon bands and transmission electron microscopy. concentration nitrate loaded the solutions slightly affected physical properties mechanical neat hydrogel. An indirect cytotoxicity study found that none were toxic to...
Background: Burn sepsis is a leading cause of mortality and morbidity in patients with major burns. The use topical antimicrobial agents has helped improve the survival these patients. Silvazine (Sigma Pharmaceuticals, Melbourne, Australia) (1% silver sulphadiazine 0.2% chlorhexidine digluconate) used exclusively Australasia, there no published study on its cytotoxicity. This compared relative cytotoxicity 1% (Flamazine (Smith & Nephew Healthcare, Hull, UK)) silver‐based dressing...
This study describes the first aid used and clinical outcomes of all patients who presented to Royal Children's Hospital, Brisbane, Australia in 2005 with an acute burn injury. A retrospective audit was performed charts 459 information concerning injury, first-aid treatment, collected. First on 86.1% patients, 8.7% receiving no unknown treatment 5.2% cases. majority had cold water as (80.2%), however, only 12.1% applied for recommended 20 minutes or longer. Recommended (cold >or=20 minutes)...
The anticonvulsant phenytoin (5,5-diphenylhydantoin) provokes a skin rash in 5 to 10% of patients, which heralds the start an idiosyncratic reaction that may result from covalent modification normal self proteins by reactive drug metabolites. Phenytoin is metabolized cytochrome P450 (P450) enzymes primarily 5-(p-hydroxyphenyl-),5-phenylhydantoin (HPPH), be further catechol spontaneously oxidizes semiquinone and quinone species covalently modify proteins. aim this study was determine P450s...
Abstract Background The efficacy of negative pressure wound therapy (NPWT) in the acute management burns remains unclear. purpose this trial was to compare standard Acticoat™ and Mepitel™ dressings with combined Acticoat™, continuous NPWT determine effect adjunctive on re-epithelialization paediatric burns. Methods This two-arm, single-centre RCT recruited children thermal covering less than 5 per cent their total body surface area. primary outcome time re-epithelialization. Blinded...