Sandra Viz-Lasheras
A5058877892- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Neonatal Respiratory Health Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Music Therapy and Health
- Bone Tumor Diagnosis and Treatments
- Neuroscience and Music Perception
- Viral gastroenteritis research and epidemiology
- Congenital Diaphragmatic Hernia Studies
- Neonatal and fetal brain pathology
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Cell Image Analysis Techniques
- Genomic variations and chromosomal abnormalities
- Mycobacterium research and diagnosis
- interferon and immune responses
- Autism Spectrum Disorder Research
- Genomics and Rare Diseases
- Diabetes and associated disorders
- Video Analysis and Summarization
- Genetic Syndromes and Imprinting
- Bone Metabolism and Diseases
Instituto de Investigación Sanitaria de Santiago
2020-2025
Servicio Gallego de Salud
2020-2025
Universidade de Santiago de Compostela
2020-2025
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2022-2025
Complejo Hospitalario Universitario de Santiago
2022
Universitat Autònoma de Barcelona
2019
Coronavirus Disease-19 (COVID-19) symptoms range from mild to severe illness; the cause for this differential response infection remains unknown. Unravelling immune mechanisms acting at different levels of colonization process might be key understand these differences. We carried out a multi-tissue (nasal, buccal and blood; n = 156) gene expression analysis immune-related genes patients affected by COVID-19 severities, healthy controls through nCounter technology. Mild asymptomatic cases...
Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast risk. FANCM, which encodes for translocase, has been proposed as predisposition gene, greater effects the ER-negative triple-negative (TNBC) subtypes. We tested three recurrent protein-truncating FANCM:p.Arg658*, p.Gln1701*, p.Arg1931* association 67,112 cases, 53,766 controls, 26,662 carriers of BRCA1 or...
Background Respiratory syncytial virus (RSV) infection has been associated with the subsequent development of recurrent wheezing and asthma, although mechanisms involved are still unknown. We investigate role epigenetics in respiratory morbidity after by comparing methylation patterns from children who develop (RW-RSV), asthma (AS-RVS), those experiencing complete recovery (CR-RSV). Methods Prospective, observational study infants aged < 2 years RSV admitted to hospital followed-up...
There is a growing interest in unraveling gene expression mechanisms leading to viral host invasion and infection progression. Current findings reveal that long non-coding RNAs (lncRNAs) are implicated the regulation of immune system by influencing through wide range mechanisms. By mining whole-transcriptome shotgun sequencing (RNA-seq) data using machine learning approaches, we detected two lncRNAs (ENSG00000254680 ENSG00000273149) downregulated infections different cell types, including...
Extensive literature has explored the beneficial effects of music in age-related cognitive disorders (ACD), but limited knowledge exists regarding its impact on gene expression. We analyzed transcriptomes ACD patients and healthy controls, pre-post a session (n = 60), main genes/pathways were compared to those dysregulated mild impairment (MCI) Alzheimer's disease (AD) as revealed by multi-cohort study 1269 MCI/AD controls). Music was associated with 2.3 times more whole-genome expression,...
Abstract Background COVID-19 symptoms range from mild to severe illness; the cause for this differential response infection remains unknown. Unravelling immune mechanisms acting at different levels of colonization process might be key understand these differences. Methods and findings We carried out a multi-tissue (nasal, buccal blood; n = 156) gene expression analysis immune-related genes patients affected by severities, healthy controls through nCounter technology. then used approach...
Abstract Recent evidence suggests that external stimuli can shape transcriptomes (sensogenomics). Specifically, the analysis of capillary blood samples has shown musical modulate gene expression patterns, in healthy individuals but also those with age-related cognitive disorders (ACD), based on. Here, we present groundbreaking indicating brief exposure to music impact salivary transcriptome both donors and ACD patients. Our findings reveal a more pronounced effect on patients compared...
Most tools for normalizing NanoString gene expression data, apart from the default nCounter software, are R packages that focus on technical normalization and lack configurable parameters. However, content is most sensitive, experiment-specific, relevant step to preprocess data. Currently this requires use of multiple a deep understanding data management by researcher. We present GUANIN, comprehensive tool integrates both new well-established methods, offering wide variety options introduce,...
Abstract Pneumonia stands as the primary cause of death among children under five, yet current diagnosis methods often result in inadequate or unnecessary treatments. Our research seeks to address this gap by identifying host transcriptomic biomarkers blood with definitive viral and bacterial pneumonia. We performed RNA sequencing on 192 prospectively collected whole samples, including 38 controls 154 pneumonia cases, uncovering a 5-transcript signature (genes FAM20A , BAG3 TDRD9 MXRA7 KLF14...
Progressive osseous heteroplasia (POH) is an ultrarare genetic disorder characterized by inactivating mutation in the GNAS gene that causes heterotopic ossification. Inhibition of mammalian target rapamycin (mTOR) signalling pathway has been proposed as a therapy for progressive bone fibrodysplasia and non-genetic forms heteroplasia. Herein, we describe impact using Everolimus rescue identical twin girl exhibiting aggressive clinical phenotype POH.Clinical evaluation progression disease...
Abstract Extensive literature has explored the beneficial effects of music in age-related cognitive disorders (ACD), but limited knowledge exists regarding its impact on gene expression. We analyzed transcriptomes ACD patients and healthy controls, pre-post a session ( n =60), main genes/pathways were compared to those dysregulated mild impairment (MCI) Alzheimer’s disease (AD) as revealed by multi-cohort study =1269 MCI/AD controls). Music was associated with 2.3 times more whole-genome...
<b>Respiratory syncytial virus (RSV)</b> infection has been associated with the subsequent development of recurrent wheezing and asthma, although mechanisms involved are still unknown. We investigate role epigenetics in respiratory morbidity after by comparing methylation patterns from children who develop (RW-RSV), asthma (AS-RVS), those experiencing complete recovery (CR-RSV). This is a prospective, observational study infants aged < 2 years RSV admitted to hospital followed-up...
Coronavirus Disease-19 (COVID-19) symptoms range from mild to severe illness. The cause for this differential response infection remains unknown. Unravelling the immune mechanisms acting at different levels of colonization process might be key understand these differences. Our study aims understanding that leads disease COVID-19 severities. We carried out a multi-tissue gene expression immune-related genes (>500) in blood, nasal, and saliva samples, collected on asymptomatic, mild,...