Purpose To evaluate the mRNA and protein expressions of NLRP3 inflammasome its downstream inflammatory factors in human dry eye. Methods We recruited 54 patients with Sjögren's syndrome eye (SSDE), 50 non-Sjögren's (NSSDE), 46 healthy controls. Tear film breakup time (TBUT), Schirmer I test, fluorescein staining (FL) were performed on all subjects. samples obtained to analyze cytokine levels IL-1β IL-18 via enzyme-linked immunosorbent (ELISA). Conjunctival impression cytology (CIC) specimens...

Abstract Background Particulate matter (PM) is strongly linked to human health and has detrimental effects on the eye. Studies have, however, focused ocular surface, with limited research impact of PM 2.5 intraocular pressure (IOP). Methods To investigate IOP associated mechanism, C57BL/6 mouse eyes were topically exposed a suspension for 3 months, trabecular meshwork (HTM) cells subjected various concentrations in vitro. Cell viability, NLRP3/caspase-1, IL-1β, GSDMD expression, reactive...

Although studies have demonstrated that fine particulate matter (PM2.5) induces ocular surface damage, PM2.5 exposure causes cornea toxicity is not entirely clear. The aim of this study to investigate the role nod-like receptor family pyrin domain containing three (NLRP3) inflammasome-mediated pyroptosis in PM2.5-related corneal toxicity. Human epithelial cells (HCECs) were exposed different concentrations PM2.5, and cell viability, expressions NLRP3 inflammasome mediated axis molecules...

Purpose: This study aimed to investigate the role and pathophysiological mechanism of ATP binding cassette transporter A1 (ABCA1) in regulating IOP aqueous humor outflow. Methods: ABCA1 expression was measured trabecular meshwork samples obtained from patients with POAG human donor eyes by Western blot. To further evaluate functional significance ABCA1, porcine angular plexus (AAP) cells, which are equivalent Schlemm's canal endothelial were either treated agonist GW3965 or transduced...

Mouse Müller cells, considered as dormant retinal progenitors, often respond to injury by undergoing reactive gliosis rather than displaying neural regenerative responses. Tumor necrosis factor alpha (TNFα) is a key cytokines induced after and implicated in mediating inflammatory responses zebrafish. To investigate the involvement of TNFα mouse injury, adult C57BL/6J mice were subjected light damage for 14 consecutive days. was elevated retina exposed damage, which cell proliferation vitro....

Purpose To report the clinical and histopathologic characteristics prognoses of three ocular juvenile xanthogranuloma (JXG) cases. Case Reports Three cases were included in this study. The first case involved a 5-year-old girl with an enlarging yellowish mass at limbus corneal involvement. Ultrasound biomicroscopy showed poorly demarcated involving underlying cornea sclera. was excised combination lamellar keratoplasty procedure. No recurrence seen 2-year follow-up. second 2-year-old boy on...

Crystal plasticity is achieved primarily through slipping. Here, a geometry-based procedure developed to facilitate the identification of slip systems in arbitrarily oriented three-dimensional periodic molecular crystals. The requires crystal structure as only input, and steric hindrance parameter denoted maximum atom overlap factor (MAOF) used quantify experienced along specific direction. Slip direction with lowest MAOF considered be most favorable. Under constraint translational symmetry...

Epidemiological studies suggest that ambient particulate matter exposure may be a new risk factor of glaucoma, but it lacks solid experimental evidence to establish causal relationship. In this study, young mice (4 weeks old) were exposed concentrated PM2.5 (CAP) for 9 months, which is throughout most the life span mouse under heavy pollution. CAP was introduced using versatile aerosol concentration enrichment system mimics natural exposure. caused gradual elevation intraocular pressure...

Recently, due to the widespread use of acetolactate synthase (ALS)-inhibiting herbicide penoxsulam in paddy fields China, Echinochloa crus-galli (L.) P. Beauv. has become a problematic grass weed that is frequently not controlled, posing threat management and rice yield. There are many reports on target-site mutations ALS inhibiting herbicides; however, detailed resistance mechanism E. remains be determined. Greenhouse laboratory studies were conducted characterize mechanisms JL-R, AH-R,...

Fine particulate matter (PM2.5) induces ocular surface toxicity through pyroptosis, oxidative stress, autophagy, and inflammatory responses. However, the precise molecular pathways which PM2.5 causes corneal damage remain unclear. This study aims to investigate underlying mechanisms by exposing human epithelial cells (HCECs) PM2.5. After morphology chemical composition analysis of PM samples, we conducted both in vivo vitro experiments PM2.5-induced damage. We assessed barrier function HCECs...

Barnyardgrass (Echinochloa crus-galli (L.) P. Beauv.), one of the worst weeds in paddy fields China, has been frequently reported evolving resistance to acetyl-CoA carboxylase (ACCase) inhibiting herbicides. However, previous research, more attention was paid target-site (TSR) mechanisms, non-target-site (NTSR) mechanisms have not well-established. In this study, potential mechanism a metamifop-resistant E. collected from Kunshan city, Jiangsu Province, China investigated. Dose-response...

Dry eye is a multifactorial disease of the tears and ocular surface that results in symptoms discomfort,visual disturbance,and tear film instability with potential damage to surface.It accompanied by increased osmolarity inflammation surface.Current studies have shown may play an important role pathological dry eye.This article reviews how leads surface.Evidence for inflammatory mechanisms accounting will be provided from following aspects:tear hyperosmolarity,ahered expression...

Abstract:  In recent years,with the rapid development of construction industry, the new building structure system and personalized building shape are constantly influencing people’s vision. The large-scale complicated is a major feature of structure.The innovation structure has increased risk in process put forward technical problems for structure. feasibility scheme safety should be fully guaranteed.In environment industrial upgrading, information model BIM been more andÂ...

Abstract Background Particulate matter (PM) is strongly linked to human health and has detrimental effects on the eye. Studies have, however, focused ocular surface, with limited research impact of PM 2.5 intraocular pressure (IOP). Methods To investigate IOP associated mechanism, C57BL/6 mouse eyes were topically exposed a suspension for 3 months, trabecular meshwork (HTM) cells subjected various concentrations in vitro . Results The results revealed that increased gradually after exposure,...