A5100607498- Lipid metabolism and biosynthesis
- Photosynthetic Processes and Mechanisms
- CRISPR and Genetic Engineering
- Advanced biosensing and bioanalysis techniques
- Microbial Metabolic Engineering and Bioproduction
- Advanced Fluorescence Microscopy Techniques
- Electrochemical sensors and biosensors
- Insect symbiosis and bacterial influences
- 2D Materials and Applications
- RNA modifications and cancer
- Algal biology and biofuel production
- Microbial Fuel Cells and Bioremediation
- Electrochemical Analysis and Applications
- Adipose Tissue and Metabolism
- Bacterial biofilms and quorum sensing
- Mass Spectrometry Techniques and Applications
- MXene and MAX Phase Materials
- Antioxidant Activity and Oxidative Stress
- Lipid Membrane Structure and Behavior
- Advanced Glycation End Products research
- Inflammatory Bowel Disease
- Genomics and Rare Diseases
- Fluorine in Organic Chemistry
- interferon and immune responses
- Evolution and Genetic Dynamics
State Key Laboratory on Integrated Optoelectronics
2018-2024
Jilin University
2018-2024
The Synergetic Innovation Center for Advanced Materials
2021-2024
Nanjing Tech University
2017-2024
Northeast Agricultural University
2023
Tianjin University
2021
Foshan University
2018
Princeton University
2017
University of Copenhagen
2015-2016
South China University of Technology
2009
Lipid droplets (LDs), which are ubiquitous organelles existing in almost all eukaryotic cells, have attracted a lot of attention the field cell biology over last decade. For biological study LDs via fluorescence imaging, superior LD fluorescent probes with environmental polarity-sensitive character highly desired and powerful but very scarce. Herein, we newly developed such kind probe named LDs-Red enables us to visualize further reveal their polarity information. This displays advantages...
Significance Bacterial migration, aggregation, and even host infection depend on the generation of mechanical force. Despite their biomedical importance, forces between bacteria surfaces have not yet been measured during migration. We present a first study bacterial cell–substrate traction using Myxococcus xanthus as model organism. M. exhibits two common mechanisms motility, namely, twitching gliding. find that these lead to distinct patterns motion an individual or in groups. Twitching...
The Sulfolobales host a unique family of crenarchaeal conjugative plasmids some which undergo complex rearrangements intracellularly. Here we examined the conjugation cycle pKEF9 in recipient strain Sulfolobus islandicus REY15A. plasmid conjugated and replicated rapidly generating high average copy numbers led to strong growth retardation that was coincident with activation CRISPR-Cas adaptation. Simultaneously, intracellular DNA extensively degraded this also occurred Δcas6 mutant lacking...
Abstract Neonatal hypotonia is extremely challenging to diagnose because numerous disorders present similar clinical manifestations. Two panels for diagnosing neonatal were developed, which enriches 35 genes corresponding 61 hypotonia-related disorders. A cohort of 214 neonates with was recruited from 2012 2014 in China this study. Of these subjects, twenty-eight eliminated according exclusion criteria and 97 confirmed using traditional detection methods. The diagnoses the remaining 89...
Evolution of complex phenotypes in cells requires simultaneously tuning expression large amounts genes, which can be achieved by reprograming global transcription. Lipophilicity is an important trait oleaginous yeast Yarrowia lipolytica. It necessary to explore the changes genes' levels will tune cellular lipophilic properties via strategy transcription engineering. We a engineering Y. lipolytica modifying sequences key transcriptional factor (TF), SPT15-like (Yl-SPT15). The combinatorial...
The synergistic effect of epigallocatechin-3-gallate (E) and quercetin (Q) enhances the therapeutic efficacy on related diseases; however, instability lower bioavailability E Q limited their application. Therefore, were co-encapsulated in hydrogel beads (H) with sodium alginate (SA) soybean protein isolate (SPI) to improve stability bioavailability. anti-inflammatory molecular mechanism action co-loaded H inflammatory bowel disease (IBD) also investigated. results showed that EQH-treated...
We described a synthesis method by first using chlorotrimethylsilane as the activator to brominate Ni(II) complex of beta-alanine Schiff's base [beta-AlaNi(II)PABA] 1 and developed it prepare beta-amino acids 5. The procedure involves Suzuki coupling reaction between boric bromoenone 2, followed hydrogenation hydrolysis. This is report application Ni (II) [beta-AlaNi(II)PABA], which represents an attractive route afford alpha-aryl-/heteroaryl-substituted acids.
To explore the effect of intervention E-cadherin (E-cad) and B-lymphoma Moloney murine leukemia virus insertion region-1 (Bmi-1) mediated by transcription activator-like effector nuclease (TALEN) on biological behaviors nasopharyngeal carcinoma cells. Methods: Multi-locus gene targeting vectors pUC-DS1-CMV-E-cad-2A-Neo-DS2 pUC-DS1-Bmi-1 shRNA-Zeo-DS2 were constructed, E-cad Bmi-1 transferred with TALEN plasmids to CNE-2 cells individually or simultaneously. The integration target genes...