A5066817104- Occupational and environmental lung diseases
- Biomarkers in Disease Mechanisms
- Photoreceptor and optogenetics research
- Air Quality and Health Impacts
- Neurobiology and Insect Physiology Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Retinal Development and Disorders
- Insect and Pesticide Research
- Occupational exposure and asthma
- Medical Imaging and Pathology Studies
- Pneumonia and Respiratory Infections
- Protein Hydrolysis and Bioactive Peptides
- Esophageal Cancer Research and Treatment
- Cancer Research and Treatments
- Aluminum toxicity and tolerance in plants and animals
- Insect and Arachnid Ecology and Behavior
- Neuroscience and Neural Engineering
- Biochemical effects in animals
- DNA Repair Mechanisms
- Advanced Glycation End Products research
- Pleural and Pulmonary Diseases
- Global Cancer Incidence and Screening
- Mosquito-borne diseases and control
- Bacterial Infections and Vaccines
- Health and Medical Studies
Centrum für Integrierte Onkologie
2024
Kantonsspital Aarau
2024
Cancer Center of Hawaii
2012-2022
University of Hawaiʻi at Mānoa
2012-2022
University of Hawaii System
2012-2022
University of Hawaii Cancer Center
2013-2022
University of New Caledonia
2010-2016
Département Mathématiques et Informatique Appliquées
2010-2016
German Sport University Cologne
2012
Institut Pasteur de Nouvelle Calédonie
2007-2011
BRCA1–associated protein 1 (BAP1) is a tumor suppressor gene located on chromosome 3p21. Germline BAP1 mutations have been recently associated with an increased risk of malignant mesothelioma, atypical melanocytic tumors and other neoplasms. To answer the question if different germline may predispose to single syndrome wide phenotypic range or distinct syndromes, we investigated presence in two unrelated families (L W) mesothelioma. Suspicious cutaneous lesions were clinically pathologically...
BRCA1-associated protein-1 (BAP1) mutations cause a new cancer syndrome, with high rate of malignant mesothelioma (MM). Here, we tested the hypothesis that MM associated germline BAP1 has better prognosis compared sporadic MM. We survival among mutation patients all (N = 10 556) recorded in United States Surveillance, Epidemiology, and End Results (SEER) data from 1973 to 2010. identified 23 patients—11 alive—with available on survival. Ten had peritoneal MM, ten pleural three both...
Abstract Purpose: To determine whether serum levels of high mobility group box protein 1 (HMGB1) could differentiate malignant mesothelioma patients, asbestos-exposed individuals, and unexposed controls. Experimental Design: Hyperacetylated nonacetylated HMGB1 (together referred to as total HMGB1) were blindly measured in blood collected from patients (n = 22), individuals with verified chronic asbestos exposure 20), benign pleural effusions 13) or not due 25), healthy controls 20). Blood...
In the honey bee drone, decrease in sensitivity to light of a retinula cell exposed background illumination was found be accurately reflected by difference amplitude between initial transient depolarization and lowest steady evoked light. It is shown that both accompanying drop potential from plateau can prevented injecting EGTA intracellularly. A duration responses short test flashes such as observed immediately after occur too when Ca or Na, but not K, Li, Mg injected into dark-adapted...
The hypothesis that most cancers are of monoclonal origin is often accepted as a fact in the scientific community. This dogma arose decades ago, primarily from study hematopoietic malignancies and sarcomas, which originate tumors. possible clonal malignant mesothelioma (MM) has not been investigated. Asbestos inhalation induces chronic inflammatory response at sites fiber deposition may lead to transformation after 30-50 years latency. As many mesothelial cells simultaneously exposed...
We recently discovered an inherited cancer syndrome caused by BRCA1-Associated Protein 1 (BAP1) germline mutations, with high incidence of mesothelioma, uveal melanoma and other cancers very penetrance age 55. To identify families the BAP1 syndrome, we screened patients family histories multiple mesotheliomas melanomas and/or cancers. identified four that shared identical mutation: they lived across US did not appear to be related. By combining histories, molecular genetics, genealogical...
Abstract Angiotensin-converting enzyme (ACE) was measured in serum of 187 healthy children between the ages six months and 18 years. Results were pooled for five-year age intervals compared with reference values adults that we previously determined [Clin Chem 1986;32:884-6). each group also studied as a function sex. Children had higher ACE activities than did (P less 0.001), but these age-related only from four to Adolescents showed sex-related differences, boys girls 0.05). Both sex-...
High incidences of malignant mesothelioma (MM) have been observed in New Caledonia. Previous work has shown an association between MM and soil containing serpentinite.We studied the spatial temporal variation its with environmental factors.We investigated 109 cases recorded Cancer Registry Caledonia 1984 2008 performed spatial, temporal, space-time cluster analyses. We conducted ecological analysis involving 100 tribes over a large area including those highest incidence rates. Associations...
When microelectrodes are inserted in two cells of the same ommatidium Limulus, current applied through membrane one cell produces a change potential across both cells. The large spikes recorded from and small other always appear synchronously. However, abolished selectively during hyperpolarizing response. discrete waves eyes adapted to darkness occur simultaneously ommatidium.
Despite predictions of decline in mesothelioma following the ban asbestos most industrial countries, incidence is still increasing globally, particularly women. Because occupational exposure to main cause mesothelioma, it occurs four- eightfold more frequently men than women, at a median age 74 years. When due an environmental exposure, M:F sex ratio 1:1 and diagnosis ~60 Studying risk challenging because long latency period small numbers, this type involuntary unknown. Individual-based...
We have developed and validated an automated kinetic method for angiotensin-converting enzyme (EC 3.4.15.1) on the Olli C + D analyzer, modified from that of Ronca-Testoni (Clin Chem 1983;29:1093-6) with N-[3-(2-furyl)-acryloyl]-L-phenylalanylglycylglycine used as substrate. determined appropriate reaction conditions assay, verified principal analytical reliability criteria (repeatability, reproducibility, sensitivity), established normal reference intervals (mean +/- SD) enzyme's activity,...
ABSTRACT New Caledonia is an archipelago in the South Pacific with a high prevalence of acute rheumatic fever and heart disease. Conducted 2006, this study aimed at characterizing clinical manifestations microbial features isolates obtained from invasive Streptococcus pyogenes Clinical demographic data were collected prospectively. Isolates biotyped, T typed, emm sequenced, tested for antibiotic susceptibility. Detection speA , speB speC ssa genes was also carried out. The estimated annual...
Similar to asbestos fibers, nonregulated mineral fibers can cause malignant mesothelioma (MM). Recently, increased proportions of women and young individuals with MM were identified in southern Nevada, suggesting that environmental exposure carcinogenic was causing the development MM. Palygorskite, a fibrous silicate history possible carcinogenicity, is abundant Nevada. In this study, our aim determine whether palygorskite contributing While palygorskite, vitro, displayed some cytotoxicity...