A5005853399- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Immune cells in cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Viral-associated cancers and disorders
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Eosinophilic Disorders and Syndromes
- Acute Myeloid Leukemia Research
- Cytomegalovirus and herpesvirus research
- Hedgehog Signaling Pathway Studies
- Cancer-related gene regulation
- HIV Research and Treatment
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- Radiopharmaceutical Chemistry and Applications
- CNS Lymphoma Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Retinoids in leukemia and cellular processes
- T-cell and Retrovirus Studies
- Cutaneous lymphoproliferative disorders research
- Axon Guidance and Neuronal Signaling
- T-cell and B-cell Immunology
- Vascular Tumors and Angiosarcomas
Moffitt Cancer Center
2016-2024
Cornell University
1998-2020
University of Chicago
2010-2020
University Health Network
2014-2020
Massachusetts General Hospital
2013-2016
Brown University
2016
Providence College
2016
University Pathologists
2016
West Virginia University
2016
King Saud University
2016
Emerging data suggest that VEGF receptors are expressed by endothelial cells as well hematopoietic stem cells. Therefore, we hypothesized functional may also be in malignant counterparts of such leukemias. We demonstrate certain leukemias not only produce but express VEGFR-2 vivo and vitro, resulting the generation an autocrine loop support leukemic cell survival proliferation. Approximately 50% freshly isolated mRNA protein for VEGFR-2. VEGF(165) induced phosphorylation increased...
BRCA1–associated protein 1 (BAP1) is a tumor suppressor gene located on chromosome 3p21. Germline BAP1 mutations have been recently associated with an increased risk of malignant mesothelioma, atypical melanocytic tumors and other neoplasms. To answer the question if different germline may predispose to single syndrome wide phenotypic range or distinct syndromes, we investigated presence in two unrelated families (L W) mesothelioma. Suspicious cutaneous lesions were clinically pathologically...
Significance Fibroblasts constitute an important element of tumors and have received considerable attention in recent years due to their tumor-promoting immunosuppressive properties. As a consequence, tumor-associated fibroblasts (TAFs) are considered attractive target for cancer therapies. However, origin remains controversial, with some evidence pointing at local origin, whereas many publications suggest significant contribution progenitors from bone marrow. We found that TAFs derive...
Primary effusion lymphoma (PEL) is a unique form of non-Hodgkin (NHL) associated with Kaposi sarcoma-associated herpesvirus (KSHV; HHV-8) that displays distinct constellation clinical, morphologic, immunologic, and molecular characteristics. Rare KSHV-containing immunoblastic lymphomas occurring in solid tissues have been described. Whether they represent part the spectrum PEL has not determined. The immunophenotypic, features KSHV-positive 8 HIV+/AIDS patients were systematically...
The distinction of hepatocellular carcinoma (HCC) from metastatic tumor in the liver often presents a diagnostic challenge that carries significant impact on prognostication and therapy. number diagnostically useful immunohistochemical markers hepatocytes is limited to hepatocyte paraffin antigen (HepPar-1), polyclonal carcinoembryonic antigen, CD10, with α-fetoprotein glypican-3 labeling HCCs. Arginase-1 (Arg-1) binuclear manganese metalloenzyme catalyzes hydrolysis arginine ornithine urea....
In this study we investigated the distribution of IgG4+ plasma cells and regulatory T (T(REG)) cells, a major regulator IgG4 production, in nodal extranodal Rosai-Dorfman disease (RDD). Twenty-six specimens (15 nodal, 11 extranodal) were examined, with reactive lymph nodes site-matched as controls. Overall, 84.6% (22/26) showed various degrees sclerosis (7 mild, 8 moderate, 7 severe). Nineteen cases (73.1%) exhibited more than 10 cells/0.060 mm(2) (photographed area at ×40), (30.8%) 40% IgG+...
Few studies describe the comprehensive immunophenotypic pattern of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in bone marrow and its treatment. This retrospective analysis evaluates diagnostic flow cytometry (FCM) outcome nine patients diagnosed with BPDCN. A four-tube 10-color FCM panel used for diagnosis acute leukemia (AL), showed cells blast gate (CD45dim/low SSC) were positive CD4(bright), CD33(dim), CD56(heterogenous), CD123(bright), CD36, CD38, HLA-DR, CD71. Seven received...
Natural killer (NK) cells inhibit early stages of tumor formation, recurrence, and metastasis. Here, we show that NK can also eradicate large solid tumors. Eradication depended on the massive infiltration proliferating due to interleukin 15 (IL-15) released presented by cancer in microenvironment. Infiltrating had striking morphologic feature being densely loaded with periodic acid-Schiff-positive, diastase-resistant granules, resembling uterine cells. Perforin-mediated killing these...
Abstract Although Hedgehog signaling plays a major role in GLI1 transcription, there is now evidence suggesting that other pathways/genes, such as c-MYC, may also regulate expression. We initiated studies Burkitt lymphoma cells, which constitutively express c-MYC due to chromosomal translocation, determine whether or regulates show all cell lines tested GLI1, PTCH1, and SMO five of six lymphomas GLI1. Exposure Sonic Indian cyclopamine (SMO inhibitor) does not modulate expression,...
Esophageal cancer incidence is increasing and has few treatment options. In studying receptor tyrosine kinases associated with esophageal cancers, we have identified EPHB4 to be robustly overexpressed in cell lines primary tumor tissues. total, 94 squamous carcinoma, 82 adenocarcinoma, 25 dysplasia, 13 Barrett esophagus, adjacent or unrelated normal tissues were evaluated by immunohistochemistry. expression was significantly higher all the different histologic categories than lines, 3 of 9...
● Context.—Atypical immature squamous metaplasia (AIM) of the cervix is a loosely defined entity characterized by metaplastic cells with mild cytologic atypia. Objective.—To examine whether combination immunostaining for p16 and Ki-67 could be used to stratify AIM cases into 3 categories: benign, nondiagnostic atypia, high-grade intraepithelial lesion (HSIL). Design.—The study consisted 37 AIM, 23 benign cervical mucosa (NEG), 36 HSIL. All were tested high-risk human papillomaviruses using...