A5025658340- Angiogenesis and VEGF in Cancer
- Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Chronic Lymphocytic Leukemia Research
- Immune cells in cancer
- Mesenchymal stem cell research
- Quality and Safety in Healthcare
- CAR-T cell therapy research
- Cancer-related gene regulation
- Colorectal Cancer Surgical Treatments
- Cancer Cells and Metastasis
- Glioma Diagnosis and Treatment
- Axon Guidance and Neuronal Signaling
- Hippo pathway signaling and YAP/TAZ
- PI3K/AKT/mTOR signaling in cancer
- Viral-associated cancers and disorders
- Hematopoietic Stem Cell Transplantation
- Colorectal Cancer Treatments and Studies
- Hemoglobinopathies and Related Disorders
- Immunotherapy and Immune Responses
- Platelet Disorders and Treatments
- Kruppel-like factors research
- Multiple Myeloma Research and Treatments
- RNA Interference and Gene Delivery
- Heparin-Induced Thrombocytopenia and Thrombosis
University of Chicago
2015-2024
United States Congress
2022
Association of Research Libraries
2022
National Center for Advancing Translational Sciences
2022
International Federation of Gynaecology and Obstetrics
2022
NorthShore University HealthSystem
2022
Temple University
2022
SUNY Cortland
2007-2019
Brigham and Women's Hospital
2010-2017
Dana-Farber Cancer Institute
2004-2014
Purpose Glioblastoma is an incurable solid tumor characterized by increased expression of vascular endothelial growth factor (VEGF). We performed a phase II study cediranib in patients with recurrent glioblastoma. Methods Cediranib, oral pan-VEGF receptor tyrosine kinase inhibitor, was administered (45 mg/d) until progression or unacceptable toxicity to The primary end point the proportion alive and free at 6 months (APF6). magnetic resonance imaging (MRI) plasma urinary biomarker...
To examine the relation of endothelial microparticles (EMPs) with cardiometabolic risk in community. Circulating EMPs are small membrane vesicles released after cell injury. Endothelial reportedly increased among individuals a high burden cardiovascular factors. However, prior investigations have been limited to small, highly selected samples. We studied 844 without history disease Framingham Offspring cohort (mean age 66 ± 9 years, 57% women). used standardized flow cytometry methods...
Abstract Mechanisms underlying tumor vasculogenesis, the homing and engraftment of bone marrow–derived vascular progenitors, remain undefined. We hypothesized that cell–secreted factors regulate vasculogenesis. studied vasculogenic nonvasculogenic intracranial murine gliomas. A PCR screen identified stromal-derived factor-1 (SDF-1/CXCL12) endothelial growth factor (VEGF) expression by glioma cells spontaneously arising tumors in NF1+/−:Trp53+/− mice, but not cells. Enforced SDF-1, VEGF,...
Most cancer patients receive radiotherapy during the course of their disease. Improvements in therapeutic index have been based mainly on physical improvements delivery, as radiosensitizer development to target tumor cells has yet yield effective agents. Recent investigations focused stroma a for radiosensitization. Here, we report that depletion tumor-associated macrophages (TAMvarphi) by systemic or local injection macrophage-depleting liposomal clodronate before can increase antitumor...
ABSTRACT A growing body of evidence suggests that endogenous antibiotics contribute to the innate defense mammalian mucosal surfaces. In cow, β-defensins constitute a large family antibiotic peptides whose members have been previously isolated from respiratory and oral mucosa, as well circulating phagocytic cells. novel bovine genomic clone with sequence related those these α-defensins was characterized. The corresponding cDNA small intestinal library; its open reading frame predicts deduced...
Purpose Circulating endothelial cells (CECs) and progenitor are currently evaluated as potential biomarkers of antiangiogenic therapy. CD146 is considered a panendothelial-specific marker, but its utility CEC marker in cancer patients remains unclear. Patients Methods We analyzed the expression on mononuclear blood cells, primary tissue malignant normal tissues by flow cytometric immunohistochemical analyses. Furthermore, we measured circulation kinetics + before, then 3 12 days after...
Ovulation induces cyclic rupture and regenerative repair of the ovarian coelomic epithelium. This process repeated disruption accompanied by complex remodeling typifies a somatic stem/progenitor cell-mediated process. Using BrdU incorporation doxycycline inducible histone2B-green fluorescent protein pulse-chase techniques, we identify label-retaining cell population in epithelium adult mouse ovary as candidate cells. The identified exhibits quiescence with asymmetric label retention,...
Endogenous type I IFN production after innate immune recognition of tumor cells is critical for generating natural adaptive responses against tumors in vivo. We recently have reported that targeting low doses IFN-β to the microenvironment using tumor-specific mAbs can facilitate antitumor immunity, which could be augmented further with PD-L1/PD-1 blockade. However, sustained high IFNs microenvironment, are potently therapeutic alone, may function through distinct mechanisms. In current...
Esophageal cancer incidence is increasing and has few treatment options. In studying receptor tyrosine kinases associated with esophageal cancers, we have identified EPHB4 to be robustly overexpressed in cell lines primary tumor tissues. total, 94 squamous carcinoma, 82 adenocarcinoma, 25 dysplasia, 13 Barrett esophagus, adjacent or unrelated normal tissues were evaluated by immunohistochemistry. expression was significantly higher all the different histologic categories than lines, 3 of 9...
We have recently demonstrated that adoptive transfer of regulatory T cell-depleted polyclonal cells into lymphopenic mice leads to rejection B16 melanoma, which generated an opportunity study host requirements for tumor when it effectively occurred. CD8(+) cell priming and required Ag cross-presentation, as evidenced by outgrowth in Kb(-/-) bone marrow chimeric or B71/2(-/-) mice. CD4(+) were additionally optimal control, although not through classical CD4 "help," the frequency primed was...
The PI3K/Akt/mTOR (PAM) axis is constitutively activated in multiple lymphoma subtypes and a promising therapeutic target. mTOR inhibitor temsirolimus (TEM) the immunomodulatory agent lenalidomide (LEN) have overlapping effects within PAM with synergistic potential. This multicenter phase I/II study evaluated combination therapy TEM/LEN patients relapsed refractory lymphomas. Primary endpoints of II were rates complete (CR) overall response (ORR). There 18 I dose-finding study, TEM 25 mg...
OBJECTIVE: To evaluate associations between use of seven progestogens and incident acute venous thromboembolism (VTE) among women reproductive age. METHODS: This nested matched case–control study identified aged 15–49 years from January 1, 2010, through October 8, 2018, in the IBM MarketScan databases, a nationwide sample private insurance claims United States. After exclusions, 21,405 with VTE (case group), by diagnosis codes, were 1:5 year birth index date risk set sampling to 107,025...