A5065230255- Wound Healing and Treatments
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Corneal Surgery and Treatments
- Skin Protection and Aging
- Silk-based biomaterials and applications
- Skin and Cellular Biology Research
- Hair Growth and Disorders
- Primary Care and Health Outcomes
- 3D Printing in Biomedical Research
- Emergency and Acute Care Studies
- Dermatologic Treatments and Research
- Cellular Mechanics and Interactions
- Health Policy Implementation Science
- melanin and skin pigmentation
- Chronic Disease Management Strategies
- Healthcare Policy and Management
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- RNA Interference and Gene Delivery
- Geriatric Care and Nursing Homes
- Cancer and Skin Lesions
- Nerve injury and regeneration
- Global Healthcare and Medical Tourism
- Healthcare Quality and Management
Université Laval
2016-2025
Centre hospitalier de l'Université Laval
2012-2023
McGill University
2006-2018
Centre Hospitalier Universitaire Sainte-Justine
2018
Hôtel-Dieu de Montréal
2018
Marymount University
2013
British Association of Dermatologists
2013
Hôpital Charles-Le Moyne
2007-2012
Université de Sherbrooke
2009-2012
Montreal Heart Institute
2007-2012
<b>Background:</b> People aged 65 years or more represent a growing group of emergency department users. We investigated whether characteristics primary care (accessibility and continuity) are associated with use by elderly people in both urban rural areas. <b>Methods:</b> conducted cross-sectional study using information for random sample 95 173 drawn from provincial administrative databases Quebec 2000 2001. obtained data on the patients9 age, sex, comorbidity, rate (number days which...
There is a clinical need for functional tissue-engineered blood vessel because small-caliber arterial graft (<5 mm) applications are limited by the availability of suitable autologous vessels and suboptimal performances synthetic grafts. This study presents an analysis mechanical properties vascular constructs produced using novel single-step self-assembly approach. Briefly, media were culturing smooth muscle cell in presence sodium l-ascorbate until formation cohesive tissue sheet. sheet...
Rationale: Prosthetic heart valves designed to be implanted percutaneously must loaded within delivery catheters whose diameter can as low 18 F (6 mm). This mandatory crimping of the devices may result in deleterious damages tissues used for valve manufacturing. As bovine and porcine pericardial tissue are currently given preference because their excellent availability traceability, a preliminary comparative study was undertaken highlight potential advantages. Materials methods: Bovine...
Split-thickness skin autografts (AGs) are the standard surgical treatment for severe burn injuries. However, of patients with substantial loss is limited by availability donor sites harvesting. As an alternative to autografts, our research group developed autologous self-assembled substitutes (SASSs), allowing replacement both dermis and epidermis in a single procedure. The aim study was assess clinical outcome SASSs as permanent coverage full-thickness wounds. Patients were recruited...
A fibroblast feeder layer is currently the best option for large scale expansion of autologous skin keratinocytes that are to be used treatment severely burned patients. In a clinical context, using human rather than mouse desirable reduce risk introducing animal antigens and unknown viruses. This study was designed evaluate if irradiated fibroblasts can in keratinocyte cultures without affecting their morphological physiological properties. Keratinocytes were grown either with or...
Background. The best alternative to a split-thickness graft for the wound coverage of patients with extensive burns should be in vitro reconstructed autologous skin made both dermis and epidermis devoid exogenous extracellular matrix proteins synthetic material. We have designed such human (rHS) present here its first vivo grafting on athymic mice. Methods. rHS was by culturing newborn or adult keratinocytes superimposed fibrous sheets obtained after fibroblasts ascorbic acid. Ten days...
An emergency department (ED) visit may be a marker for limited access to primary medical care, particularly among those with ambulatory care sensitive chronic conditions (ACSCC).In population universal health insurance, examine the relationships between characteristics and location of last general physician (GP) contact (in an ED vs. elsewhere) without ACSCC.A cross-sectional survey using data from 2 cycles Canadian Community Health Survey carried out in 2003 2005.The study sample comprised...
There is a clinical need for better blood vessel substitutes, as current surgical procedures are limited by the availability of suitable autologous vessels and suboptimal behavior synthetic grafts in small caliber arterial graft (<5 mm) applications. The aim present study was to compare mechanical properties venous tissue-engineered vascular constructs produced self-assembly approach using cells extracted from either artery or vein harvested same human umbilical cord. production construct...
There is a clinical need for skin substitutes to replace full-thickness loss. Our group has developed bilayered substitute produced from the patient's own fibroblasts and keratinocytes referred as Self-Assembled Skin Substitute (SASS). After cell isolation expansion, current time required produce SASS 45 days. We aimed optimize manufacturing process standardize production of reduce time. The new approach consisted in seeding on fibroblast-derived tissue sheet before its detachment culture...
In the rapidly growing field of tissue engineering, functional properties substitutes are recognized as being utmost importance. The present study was designed to evaluate effects static mechanical forces on functionality produced constructs. Living sheets reconstructed by self-assembly approach from human cells, without addition synthetic material or extracellular matrix (ECM), were subjected load induce cell and ECM alignment. addition, alignment function these living evaluated. Our...
To explore hospital characteristics and indicators of emergency department (ED) care older patients associated with return visits to the ED.Provincial databases in province Quebec, Canada, a survey ED geriatric services were linked at individual level, respectively. All general acute adult hospitals least 100 eligible who visited an during 2001 included (N = 80). The study population 140,379) comprised community-dwelling individuals aged 65 years made initial visit discharged home....
Objective: A 2002 survey of primary healthcare sites found that 51% rural and 33% urban care patients reported using the hospital emergency room (ER) in last 12 months.We did a secondary analysis to identify urban-rural differences accessibility-related organizational features predicted ER use.Methods: We collected information on clinic organization physicians' practice profiles from 100 across Quebec 2,725 their regular patients, who use.We used hierarchical logistic regression predict...
Despite present optimal standard treatment of lower-extremity ulceration, a high incidence recurrence and failure is observed. The objective this project was to evaluate the effect self-assembled skin substitute (SASS) made by tissue engineering as temporary cutaneous dressing in hard-to-heal chronic ulcers.The prospective uncontrolled case study includes patients suffering from venous or mixed ulcers lasting more than 6 months unresponsive compression therapy, with an Ankle Brachial Index...
Defining the properties of postnatal stem cells is interest given their relevance for tissue homeostasis and therapeutic applications, such as skin engineering burn patients. In hair follicles, bulge region outer root sheath houses cells. We show that explants from prominent area, but not bulb, in rodent vibrissa follicles can produce epidermis a model engineering. Using morphological criteria keratin expression, we typified epithelial bulge. Two types slow-cycling (Bb, Bs1) featuring high...
Burn patients treated with tissue-engineered skin substitutes (TESs) often experience pigmentation irregularities, including hypopigmentation and spots. These issues are thought to stem from the reduced presence of melanocytes through dilution during TES manufacturing. To address this, we hypothesized that supplementing epithelial cell cultures-primarily composed keratinocytes but also containing melanocytes-with Fibroblast Growth Factor-2 (FGF-2), a known promoter melanocyte proliferation,...
Hair follicle stem cells, located in the bulge region of outer root sheath, are multipotent epithelial cells capable differentiating into epidermal, sebaceous gland, and hair shaft cells. Efficient culturing these is crucial for advancements dermatology, regenerative medicine, skin model development. This investigation aimed to develop a protocol isolating enriched bulge-derived from scalp specimens produce tissue-engineered substitutes. The epithelium, including follicles, was separated...
The skin is a dynamic tissue in which terminally differentiated keratinocytes are replaced by the proliferation of new epithelial cells that will undergo differentiation. rapid and continual turnover throughout life depends on cell population with unique characteristics: stem cells. These relatively undifferentiated, retain high capacity for self-renewal their lifetime, have large proliferative potential, normally slow cycling. long-term regeneration grafted cultured epidermis indicates...
ObjectivesTo explore hospital characteristics and indicators of emergency department (ED) care older patients associated with return visits to the ED. MethodsProvincial databases in province Quebec, Canada, a survey ED geriatric services were linked at individual level, respectively. All general acute adult hospitals least 100 eligible who visited an during 2001 included (N= 80). The study population 140,379) comprised community-dwelling individuals aged 65 years made initial visit...