A5084954969- Gastrointestinal motility and disorders
- Health Systems, Economic Evaluations, Quality of Life
- Medication Adherence and Compliance
- Gastroesophageal reflux and treatments
- Pharmaceutical Economics and Policy
- Blood Pressure and Hypertension Studies
- Pharmaceutical Practices and Patient Outcomes
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Asthma and respiratory diseases
- Bone health and treatments
- Statistical Methods in Clinical Trials
- Dermatology and Skin Diseases
- Schizophrenia research and treatment
- Pharmaceutical industry and healthcare
- Inflammatory mediators and NSAID effects
- Pharmaceutical studies and practices
- Heart rate and cardiovascular health
- Menopause: Health Impacts and Treatments
- Meta-analysis and systematic reviews
- Bone health and osteoporosis research
- Heart Failure Treatment and Management
- Child Nutrition and Feeding Issues
- Advanced Causal Inference Techniques
- Urinary Bladder and Prostate Research
Novartis (United States)
2010-2022
Tris Pharma (United States)
2006-2017
Novem (Netherlands)
2016
Novartis (Switzerland)
2003-2015
Statistical Research (United States)
2011
Hanover College
2011
Benchmark Research (United States)
2006-2007
VA New Jersey Health Care System
2007
Mayo Clinic in Arizona
2007
Mayo Clinic in Florida
2007
Previous research has provided evidence that in the last decade, investing according to screening based on environmental, social, and governance (ESG) criteria would have allowed investors considerably improve ESG quality of their portfolio without deterioration its financial performance. However, a drawback such process is it may generate undesirable regional, sectoral, risk factor exposures. In this article, authors propose an investment strategy maximizes while maintaining exposures...
Studies that generate real-world evidence on the effects of medical products through analysis digital data collected in clinical practice provide key insights for regulators, payers, and other healthcare decision-makers. Ensuring reproducibility such findings is fundamental to effective evidence-based decision-making. We reproduce results 150 studies published peer-reviewed journals using same databases as original investigators evaluate completeness reporting 250. Original reproduction...
In Brief Objective: The aim of this study was to quantify the magnitude risk reduction for venous thromboembolism events associated with an estradiol transdermal system relative oral estrogen-only hormone therapy agents. Methods: A claims analysis conducted using Thomson Reuters MarketScan database from January 2002 October 2009. Participants 35 years or older who were newly two more dispensings analyzed. Venous defined as one diagnosis codes deep vein thrombosis pulmonary embolism. Cohorts...
To identify associations between systemic medications and primary open-angle glaucoma (POAG) requiring a procedure using United States insurance claims data in hypothesis-generating study.Database study.In total, 6130 POAG cases (defined as patients with undergoing procedure) were matched to 30 650 controls cataract surgery but without coded diagnosis, procedure, or medication) by age, gender, region of residence.Participant prescription drug use was calculated for the 5-year period before...
OBJECTIVE—In Canada, diabetes poses a significant health problem, and current estimates of its economic burden have not incorporated the total cost disease. The objective this study was to quantify direct medical- mortality-related productivity in Canada for 1998. RESEARCH DESIGN AND METHODS—Direct medical costs included hospital services, physician medicines consumed by people with diabetes. These were based on top-down costing methodology that allocated 1998 expenditures prevalence...
Objectives:To compare compliance/persistence, health care resource utilization, and costs associated with single-pill combination (SPC) vs. free-combination (FC) therapies among adult hypertension patients at the national state level. Combination angiotensin receptor blocker (ARB) + calcium channel blocker, ARB hydrochlorothiazide, angiotensin-converting enzyme inhibitor hydrochlorothiazide were evaluated.Methods:Patients initiated on SPC or FC identified in MarketScan Database (2006–2008)....
Abstract Objective: To evaluate the risk of venous thromboembolism (VTE) and cardiovascular disease (CVD) complications, assess healthcare costs in menopausal women using an estradiol transdermal system versus oral estrogen therapy (ET). Methods: Health insurance claims from 60 self-insured US companies 1999 to 2011 were analyzed. Women at least 50 years age, newly initiated on or ET, included. Cohorts matched 1:1 based exact factors propensity score-matching methods. The incidence rate...
The effectiveness of chronic therapies can be compromised by poor adherence and persistence.Investigators identified a continuously benefit-eligible cohort women from large, geographically diverse, national managed care plan who were newly diagnosed treated for osteoporosis with alendronate, risedronate, or raloxifene. Drug utilization parameters evaluated over 12-month follow-up period the study population. Adherence was assessed using medication possession ratio calculated as total days...
Summary Aims To estimate the relative risk for ischaemic colitis in patients with and without irritable bowel syndrome or constipation, to evaluate role of constipation as confounders relationship between commonly used gastrointestinal medications colitis. Methods Patient cohorts were identified use longitudinal MarketScan research databases from 1 January 1999 31 December 2002. Patients each study cohort matched 1:1 comparable control using a propensity score. A Cox proportional hazards...
Abstract Ischaemic colitis (IC) has been associated with a number of diverse disorders and risk factors, including irritable bowel syndrome (IBS) constipation. We sought to assess, through large‐scale population study, the potential factors IC. Patients IC matched controls without were identified using medical pharmacy claims data from HealthCore Managed Care Database 1st January 2000 31st May 2005. A multivariate conditional logistic regression model was developed identify significant...
Study Type – Symptom prevalence (retrospective cohort) Level of Evidence 2b OBJECTIVE To determine if cardiovascular (CV) comorbidity and treatment‐associated antimuscarinic effects differ between patients with without overactive bladder (OAB), treated untreated OAB, as CV disorders exposure to medications are common in older patients. PATIENTS AND METHODS Adults from the HealthCore Integrated Research Database a diagnosis OAB (International Classification Diseases‐9 codes; 1 January 2000 31...
The objective of this analysis was to evaluate the impact several classes oral antihyperglycemic therapy relative sulfonylurea monotherapy on all-cause mortality among a cohort patients with diabetes from Veterans Health Administration (VHA).A retrospective study using data obtained VHA Diabetes Epidemiology Cohort used. Users were classified into following cohorts: monotherapy, metformin plus sulfonylurea, thiazolidinedione (TZD) use alone or in combination other agents (TZD users), and no...
Aim: To analyze the impact of COVID-19 pandemic on US healthcare resource utilization. Methods: Optum claims data were used to compare all-cause visits and spending for selected diseases between prepandemic periods. Telemedicine use was only assessed period owing availability. Results: During first wave pandemic, across all disease areas displayed a rapid decline compared with period, followed by recovery. A reduction in outpatient home observed, whereas inpatient prescription increased....
The goal of this research was to compare the demographics, clinical characteristics and treatment patterns for newly diagnosed multiple sclerosis (MS) patients in a commercial managed care population who received disease-modifying drug (DMD) therapy versus those not receiving DMD therapy. A retrospective cohort study using US administrative healthcare claims identified individuals with MS (no prior diagnosis 12 months ICD-9-CM 340) ≥ 18 years old during 2001-2007 characterize them based on...
Proportion of days covered (PDC), a commonly used adherence metric, does not provide information about the longitudinal course to treatment over time. Group-based trajectory model (GBTM) is an alternative method that overcomes this limitation.The statistical principles GBTM and PDC were applied assess during 12-month follow-up in psoriasis patients starting with biologic. The optimal was determined on basis balance between each model's Bayesian criterion percentage smallest group model....