A5102830578- Oral microbiology and periodontitis research
- Dental Implant Techniques and Outcomes
- Genomics and Chromatin Dynamics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Barrier Structure and Function Studies
- S100 Proteins and Annexins
- Rheumatoid Arthritis Research and Therapies
- PI3K/AKT/mTOR signaling in cancer
- Proteoglycans and glycosaminoglycans research
- Hippo pathway signaling and YAP/TAZ
- Gastric Cancer Management and Outcomes
- Dental materials and restorations
- Fault Detection and Control Systems
- Salivary Gland Disorders and Functions
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Graphene and Nanomaterials Applications
- Dental Radiography and Imaging
- Soft tissue tumor case studies
- Hydraulic Fracturing and Reservoir Analysis
- Boron Compounds in Chemistry
- Inflammasome and immune disorders
- Biomarkers in Disease Mechanisms
- Machine Fault Diagnosis Techniques
- Carbon and Quantum Dots Applications
Union Hospital
2015-2025
Fujian Medical University
2015-2025
Southern Medical University
2020-2024
Nanjing Tech University
2024
Chongqing Medical University
2023-2024
Shenzhen University
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Zhujiang Hospital
2024
Northeastern University
2024
Wenzhou Medical University
2023
In rheumatoid arthritis (RA), a debilitating autoimmune disorder marked by chronic synovial inflammation and progressive cartilage degradation, fibroblast-like synoviocytes (FLS) are key pathogenic players.Current treatments targeting these cells limited.Our study focused on the Fat Mass Obesity-associated protein (FTO), known for its roles in cell proliferation inflammatory response modulation, involvement RA.We specifically examined regulatory of FTO CMPK2, mitochondrial DNA synthesis...
Hyperspectral unmixing, which decomposes mixed pixels into the endmembers and corresponding abundances, is an important image process for further application of hyperspectral images (HSIs). Lately, unmixing problem has been solved using deep learning techniques, particularly autoencoders (AEs). However, majority them are based on simple linear mixing model (LMM), disregards spectral variability in different pixels. In this article, we present a multi-attention AE network (MAAENet) extended...
Background: Gastric cancer (GC) ranks as the fifth leading cause of mortality, with stem cells (CSCs) playing a critical role in tumor progression and resistance to chemotherapy. Conventional chemotherapy often fails effectively target these cells. BATF2, suppressor, is known for its gastric cancer, but influence on cell-like properties response remains unclear. Methods: Single-cell RNA sequencing (scRNA-seq) analysis was performed 9 samples evaluate expression regulatory function BATF2. In...
Rheumatoid arthritis (RA) is a common chronic inflammatory disease characterized by the proliferation of fibroblast-like synoviocytes (FLS), pannus development, cartilage, and bone degradation, and, eventually, loss joint function. Fibroblast activating protein (FAP) particular product activated FLS highly prevalent in RA-derived (RA-FLS). In this study, zinc ferrite nanoparticles (ZF-NPs) were engineered to target FAP
This study aimed to investigate the role and regulatory mechanisms of Ezrin in synovial vessels rheumatoid arthritis (RA). Synovial tissues were obtained from people with osteoarthritis patients RA patients. We also used an antigen-induced (AIA) mice model by using Freund's adjuvant injections. expression was analysed immunofluorescence immunohistochemical staining AIA mice. investigated on vascular endothelial cells its mechanism vivo vitro adenoviral transfection technology. Our results...
RNA polymerase III (pol III) products play fundamental roles in a variety of cellular processes, including protein synthesis and cancer cell proliferation. In addition, dysregulation pol III-directed transcription closely correlates with tumorigenesis. It is therefore interest to identify novel pathways or factors governing transcription. Here, we show that factor (TF) GATA binding 4 (GATA4) expression SaOS2 cells was stimulated by the silencing filamin A (FLNA), repressor transcription,...
Basal progenitor cells serve as a stem cell pool to maintain the homeostasis of epithelium foregut, including esophagus and forestomach. Aberrant genetic regulation in these can lead carcinogenesis, such squamous carcinoma (SCC). However, underlying molecular mechanisms regulating function basal remain largely unknown. Here, we use mouse models reveal that Hippo signaling is required for maintaining foregut cooperates with p53 repress initiation SCC. Deletion Mst1/2 mice leads epithelial...
Abstract Background Cancer stem cells (CSCs) are critical factors that limit the effectiveness of gastric cancer (GC) therapy. Circular RNAs (circRNAs) confirmed as important regulators many cancers. However, their role in regulating CSC-like properties GC remains largely unknown. Our study aimed to investigate circUBA2 CSC maintenance and underlying mechanisms. Methods We identified an upregulated gene using circRNA microarray analysis. qRT-PCR was used examine levels normal tissues. In...
RNA polymerase III (Pol III) products play essential roles in ribosome assembly, protein synthesis, and cell survival. Deregulation of Pol-III-directed transcription is closely associated with tumorigenesis. However, the regulatory pathways or factors controlling remain to be investigated. In this study, we identified a novel role EGR1 transcription. We found that Filamin A (FLNA) silencing stimulated expression at both levels. positively correlated Pol product levels proliferation activity....
BACKGROUND Proximal contact loss (PCL) is very common between implant-fixed prostheses (IFPs) and adjacent teeth leads to a high incidence of food impaction. Our aim was determine if the mesio-distal adjustable (MDA) crown introduced in this study could easily establish new contacts intraorally without intervention retrieval. MATERIAL AND METHODS The MDA requires casting inlay framework at proximal area. If PCL occurred, resin be removed refilled chairside. This single-center prospective...
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To describe an esthetic flap design for surgical endodontics in the anterior zone and to discuss treatment outcome.
To explore the impact of visceral fat area (VFA) on short- and long-term efficacy indocyanine green (ICG)-guided D2 lymphadenectomy for gastric cancer (GC).