A5101735193- Neuroinflammation and Neurodegeneration Mechanisms
- Metal complexes synthesis and properties
- Acute Ischemic Stroke Management
- Ferrocene Chemistry and Applications
- Selenium in Biological Systems
- Chemotherapy-induced organ toxicity mitigation
- Acute Kidney Injury Research
- Trace Elements in Health
- Sphingolipid Metabolism and Signaling
- Traumatic Brain Injury and Neurovascular Disturbances
- Immune Response and Inflammation
- Neurological Disease Mechanisms and Treatments
- Barrier Structure and Function Studies
- Magnetism in coordination complexes
- Stroke Rehabilitation and Recovery
- Pomegranate: compositions and health benefits
- Photodynamic Therapy Research Studies
- Cytokine Signaling Pathways and Interactions
- Advanced Nanomaterials in Catalysis
- Porphyrin and Phthalocyanine Chemistry
- Chronic Kidney Disease and Diabetes
- Kidney Stones and Urolithiasis Treatments
- Adrenal and Paraganglionic Tumors
- Nanocluster Synthesis and Applications
- Postharvest Quality and Shelf Life Management
Xiangshan County First People's Hospital
2024
Peking University
2024
Peking University Third Hospital
2024
Central South University
2021-2023
Center for Cancer Research
2016-2023
Second Xiangya Hospital of Central South University
2021-2023
National Cancer Institute
2023
National Institutes of Health
2023
First Affiliated Hospital of Fujian Medical University
2021-2023
Fujian Medical University
2021-2023
Inflammatory and immune responses triggered by brain ischemia worsen clinical outcomes of stroke contribute to hemorrhagic transformation, massive edema, reperfusion injury associated with intravenous alteplase. We assessed whether a combination the immune-modulator fingolimod alteplase is safe effective in attenuating patients acute ischemic treated within first 4.5 hours symptom onset.In this multicenter trial, we randomly assigned 25 eligible hemispheric stemming from anterior or middle...
Significance In patients with acute ischemic stroke (AIS), the abrupt and massive influx of lymphocytes from periphery to region orchestrates focal inflammatory responses, catalyzes tissue death, worsens clinical outcomes. this early phase study, we reduced lymphocyte migration brain during first 72 h AIS via oral administration three doses fingolimod. This led a significant reduction secondary lesion enlargement, microvascular permeability, better outcomes 3-mo follow-up visit. study will...
The present study was undertaken to determine the efficacy of coadministration fingolimod with alteplase in acute ischemic stroke patients a delayed time window.This prospective, randomized, open-label, blinded endpoint clinical trial, enrolling internal carotid artery or middle cerebral proximal occlusion within 4.5 6 hours from symptom onset. Patients were randomly assigned receive alone fingolimod. All underwent pretreatment and 24-hour noncontrast computed tomography (CT)/perfusion CT/CT...
Rationale: Cisplatin, a potent chemotherapeutic drug, induces side effects in normal tissues including the kidney.To reduce effects, repeated low-dose cisplatin (RLDC) is commonly used clinical setting.While RLDC reduces acute nephrotoxicity to certain extents, significant portion of patients later develop chronic kidney problems, underscoring need for novel therapeutics alleviate long-term sequelae therapy.Methods: In vivo, role HMGB1 was examined by testing neutralizing antibodies mice.In...
Significance Platinum-based metallodrugs are the most widely used anticancer agents. Their reduced effectiveness after repeat dosing (resistance) constitutes a major clinical problem. We study potent organo-osmium compound with improved activity over cisplatin and no cross-resistance in platinum-resistant cancers. This disrupts metabolism A2780 human ovarian cancer cells, generating reactive oxygen species damaging DNA. identified mutations complex I of electron transport chain cells suggest...
Chronic inflammation contributes to maladaptive kidney repair, but its regulation is unclear. Here, we report that sirtuin 1 (SIRT1) downregulated after repeated low-dose cisplatin (RLDC) injury, and this downregulation leads p65 acetylation consequent NF-κB activation resulting in a persistent inflammatory response. RLDC induced the down-regulation of SIRT1 NF-κB, which were accompanied by chronic tubular damage, tubulointerstitial inflammation, fibrosis mice. Inhibition suppressed...
Recent studies have demonstrated that lymphocytes play a key role in ischemic brain injury. However, there is still lack of viable approaches to non-invasively track infiltrating and reveal their spatiotemporal events the inflamed central nervous system (CNS). Here we describe an vivo imaging approach for sequential monitoring brain-infiltrating CD4 + T cells experimental stroke. We show magnetic resonance (MRI) or Xenogen combined with labeling SPIO-Molday ION Rhodamine-B (MIRB) can be used...
Half-sandwich Os-arene complexes exhibit promising anticancer activity, but their photochemistry has hardly been explored. To exploit the photocytotoxicity and of Os-arenes, O,O-chelated [Os(η6-p-cymene)(Curc)Cl] (OsCUR-1, Curc = curcumin) [Os(η6-biphenyl)(Curc)Cl] (OsCUR-2), N,N-chelated [Os(η6-biphenyl)(dpq)I]PF6 (OsDPQ-2, dpq pyrazino[2,3-f][1,10]phenanthroline) [Os(η6-biphenyl)(bpy)I]PF6 (OsBPY-2, bpy 2,2'-bipyridine), have investigated. The curcumin showed remarkable toward a range...
Abstract Dinuclear trihydroxido‐bridged osmium–arene complexes are inert and biologically inactive, but we show here that linking dihydroxido‐bridged Os II –arene fragments by a bridging di‐imine to form metallacycle framework results in strong antiproliferative activity towards cancer cells distinctive knotting of DNA. The shortened spacer length reduces biological stability solution decomposition inactive dimers. Significant differences behavior toward plasmid DNA condensation correlated...
Journal Article Survey on risk perception of radiation following an incident involving a stuck 60Co source in Henan province, China Get access Cuiping Lei, Lei 1Chinese Center for Medical Response to Radiation Emergency, National Institute Radiological Protection, CDC, Beijing 100088, Search other works by this author on: Oxford Academic PubMed Google Scholar Quanfu Sun, Sun Xiaojun Cheng, Cheng 2Henan Provincial Occupational Health, Zhengzhou, 450052, Qingfu Zhang, Zhang Yinghua Fu, Fu...
Objective To investigate the present prevalence state of children's Kaschin-Beck disease (KBD) in Xinghai county Qinghai province,a relative active KBD area 2009,and to their nutritional selenium level local children and T-2 toxin contamination staple food.Methods Right hand X-ray photographs aged 7 - 12 Shang,Zhong Xia villages Tangnaihai countryside were taken.X-ray diagnosis was carried out according Diagnostic Criteria Kashin Beck Disease (GB 16003-1995 ).Selected samples (children's...
Abstract Background Computed tomography angiography (CTA) and magnetic resonance (MRA) provide accurate vascular imaging information, but their use may be contraindicated. Color Doppler ultrasonography (CDU) provides simple, safe, noninvasive, reproducible imaging. We therefore investigated the role of preoperative CDU combined with CTA MRA in quantification, typing, diagnosis carotid body tumors (CBTs). Methods retrospectively analyzed patients CBTs categorized into group A (type I [n = 1]...
Objective To investigate the children's body environmental Se and T-2 toxin level in their staple food Kaschin-Beck disease(KBD)relative active regions Aba state of Sichuan province 2008.Methods We took X-ray photograph right hand on children aged 7-13 years 48 villages from 11 counties state.The relative KBD were chosen according to result historical status KBD.The urine hair,drinking water werr sampled.Selenium contents urine,hair,water samples determined by naphthalene fluorescence,and...
Abstract Dinuclear trihydroxido‐bridged osmium–arene complexes are inert and biologically inactive, but we show here that linking dihydroxido‐bridged Os II –arene fragments by a bridging di‐imine to form metallacycle framework results in strong antiproliferative activity towards cancer cells distinctive knotting of DNA. The shortened spacer length reduces biological stability solution decomposition inactive dimers. Significant differences behavior toward plasmid DNA condensation correlated...
Background Noninvasive evaluation of the status cerebral arteriole perfusion remains a practical challenge in murine stroke models, because conventional magnetic resonance imaging (MRI) is no longer capable capturing these very small vessels. Purpose To investigate feasibility ultrasmall superparamagnetic iron oxide particles (USPIO)‐based susceptibility weighted (SWI)‐MRI (USPIO‐SWI) and T2* map‐MRI (USPIO‐T2* map) for monitoring angiographic rats. Study Type A preclinical randomized...
Deutliche Unterschiede bei der Wechselwirkung mit DNA könnten über die antiproliferative Wirkung von OsII-Aren-Metallacyclen entscheiden. In Zuschrift auf S. 9055 ff. beschreiben P. J. Sadler et al. zwei vierkernige metallorganische OsII-Komplexe starken Abweichungen Zytotoxizität für Krebszellen und dem Verhalten gegenüber DNA-Kondensation. Es besteht eine Korrelation zwischen Spacerlänge im Metallacyclus, Beständigkeit in Lösung biologischen Aktivität.