A5013180156- Reproductive tract infections research
- Syphilis Diagnosis and Treatment
- Bacterial Infections and Vaccines
- Genital Health and Disease
- Streptococcal Infections and Treatments
- Urologic and reproductive health conditions
- Herpesvirus Infections and Treatments
- Blood groups and transfusion
- Reproductive Health and Contraception
- Adolescent Sexual and Reproductive Health
- Cytokine Signaling Pathways and Interactions
- Urinary Tract Infections Management
- HIV, TB, and STIs Epidemiology
- Autoimmune Bullous Skin Diseases
- Legume Nitrogen Fixing Symbiosis
- Dermatological and Skeletal Disorders
- Cancer Mechanisms and Therapy
- Urinary and Genital Oncology Studies
- Urticaria and Related Conditions
- Genetic and rare skin diseases.
- Body Image and Dysmorphia Studies
- Amoebic Infections and Treatments
- Female Genital Mutilation/Cutting Issues
- Vascular Tumors and Angiosarcomas
- Risk Perception and Management
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Chinese Academy of Medical Sciences Dermatology Hospital
2011-2024
Institute of Dermatology
2017-2019
The University of Texas MD Anderson Cancer Center
2019
Peking University
2019
China University of Petroleum, Beijing
2014
Chinese Center For Disease Control and Prevention
2012-2014
University of Massachusetts Chan Medical School
2006-2013
Guangzhou Institute of Dermatology
2013
Peking Union Medical College Hospital
2010
ABSTRACT The unmet medical need for novel intervention strategies to treat Neisseria gonorrhoeae infections is significant and increasing, as rapidly emerging resistance in this pathogen threatening eliminate the currently available treatment options. AZD0914 a bacterial gyrase inhibitor that possesses potent vitro activities against isolates with high-level ciprofloxacin extended-spectrum cephalosporins, it clinical development of N. infections. propensity develop was examined found be...
The emergence of ceftriaxone-resistant strains Neisseria gonorrhoeae may herald an era untreatable gonorrhea. Vaccines against this infection are urgently needed. 2C7 epitope is a conserved oligosaccharide (OS) structure, part lipooligosaccharide (LOS) on N gonorrhoeae. expressed by 94% gonococci that reside in the human genital tract (in vivo) and 95% first passaged isolates. Absence shortens time gonococcal carriage mouse model infection. To circumvent limitations saccharide immunogens...
Mycoplasma genitalium (MG) causes symptomatic urethritis in men, and can infect alone or together with other sexually transmitted infection (STI) agents.
Adequate nutrition is needed to ensure optimum growth and development of infants young children. Although the national economy has developed rapidly during recent decades in China, malnutrition continues be a major public health problem. The aim present study was undertaken assess prevalence risk factors associated with stunting severe under 3 years old mid-western rural areas China.A community-based cross-sectional survey carried out 84 villages provinces China 2010. A total 1260 children...
Gonorrhea is a highly prevalent disease resulting in significant morbidity worldwide, with an estimated 106 cases reported annually. Neisseria gonorrhoeae, the causative agent of gonorrhea, colonizes and infects human genital tract often evades host immune mechanisms until successful antibiotic treatment used. The alarming increase antibiotic-resistant strains N. asymptomatic nature this women lack vaccine directed at crucial virulence determinants have prompted us to perform transcriptome...
The aim of this study was to assess the efficacy ceftriaxone and benzathine penicillin G (BPG) in nonpregnant, immunocompetent adults with early syphilis because there is a lack clinical evidence supporting as an alternative treatment for without human immunodeficiency virus coinfection.A randomized, open-label controlled evaluating BPG conducted 4 hospitals Jiangsu Province. Treatment comprised either (1.0 g, given intravenously, once daily 10 days) or (2.4 million units, intramuscularly,...
Azithromycin resistance (AZM-R) of
Sialylation of lacto- N -neotetraose (LNnT) extending from heptose I (HepI) gonococcal lipooligosaccharide (LOS) contributes to pathogenesis. Previously, LOS sialyltransterase (Lst) was shown sialylate in Triton X-100 extracts strain 15253, which expresses lactose both HepI and HepII, the minimal structure required for monoclonal antibody (MAb) 2C7 binding.
To monitor the frequency and types of antibiotic resistance Neisseria gonorrhoeae in Nanjing, China, between 1999 2006.beta-Lactamase production was determined by paper acidometric testing. Minimum inhibitory concentrations (MICs) to penicillin, ceftriaxone, tetracycline, ciprofloxacin, spectinomycin were agar plate dilution. Plasmid for TRNG PPNG isolates PCR.One-thousand two-hundred eight N. examined. The rate rose from 8.0% (9 112) 57.36% (113 197) 2004, declined 44.44% (88 198) 2006....
We tested the activity of ETX0914 against 187 Neisseria gonorrhoeae isolates from men with urethritis in Nanjing, China, 2013. The MIC50, MIC90, and MIC range for were 0.03 μg/ml, 0.06 ≤0.002 to 0.125 respectively. All resistant ciprofloxacin, 36.9% (69/187) azithromycin. Of isolates, 46.5% penicillinase-producing N. (PPNG), 36% tetracycline-resistant (TRNG), 13% (24 isolates) had an μg/ml ceftriaxone. may be effective treatment option gonorrhea.
Antimicrobial resistance (AMR) and genetic determinants of N. gonorrhoeae isolates from Hefei, China, were characterized adding a breadth information to the molecular epidemiology gonococcal in China.126 hospital clinic collected between January, 2014, November, 2015. The minimum inhibitory concentration (MIC) for seven antimicrobials determined by agar dilution method. Isolates tested mutations penA mtrR genes 23S rRNA, also genotyped using multi-antigen sequence typing (NG-MAST).All...
Recent emergence of antimicrobial resistance Neisseria gonorrhoeae worldwide has resulted in limited therapeutic choices for treatment infections caused by this organism. We performed global transcriptomic analysis N. subjects with gonorrhea who attended a Nanjing, China, sexually transmitted infection (STI) clinic, where is high and increasing. found that transcriptional responses to differed genital specimens taken from men women, particularly antibiotic gene expression, which was...
Gonorrhea is the second most common sexually transmitted diseases worldwide. Chronic infection of Neisseria gonorrhoeae (N. gonorrhoeae) can lead to severe complications. Presently, N. has developed resistance almost all antibiotics used for treatment gonorrhea. Thus, it's urgent explore new approaches treat nontraditional method as an alternative antibiotic use getting more and attention. Here we demonstrated that 18β-glycyrrhetinic acid (GRA) exhibited robust antimicrobial activity against...
Evolving gonococcal antimicrobial resistance (AMR) poses a serious threat to public health. The aim of this study was to: update susceptibility data Neisseria gonorrhoeae recently isolated in Nanjing, China and identify specific deteminants gentoypes isolates with decreased sensitivity ceftriaxone. 334 N. were collected consecutively from symptomatic men attending the Nanjing STD Clinic between April 2011 December 2012. minimum inhibitory concentrations (MICs) for penicillin, tetracycline,...
ABSTRACT In Denmark surveillance of the in vitro susceptibility to ciprofloxacin Neisseria gonorrhoeae was established 1990. The proportion N. strains with decreased or resistance (MIC ≥ 0.06 μg/ml) low (0.3 2.3%) up 1995. Between 1995 and 1998 rate less-susceptible resistant rose from 6.9 13.2%. Among ciprofloxacin-resistant 1 μg/ml), 81% were highly 4 μg/ml). Thirty-five (40 isolates) for which MICs 32 μg/ml investigated frequency patterns mutations within gyrA parC genes. quinolone...
The prevalence of sexually transmitted diseases (STDs) has been increasing in China since the 1980s. Because gonorrhea is most frequently reported STD there, information on antimicrobial susceptibility Neisseria gonorrhoeae will aid its control.To investigate N isolates and to provide data for formulation treatment guidelines control policies.The agar dilution technique was used determine susceptibility, acidimetric method test penicillinase-producing gonorrhoeae.A total 3186 gonococcal were...
Previously, we reported the potent activity of a novel spiropyrimidinetrione, zoliflodacin, against Neisseria gonorrhoeae isolates collected in 2013 from symptomatic men Nanjing, China. Here, investigated trends susceptibilities to zoliflodacin 986 between 2014 and 2018. N. were tested for susceptibility seven other antibiotics.
Neisseria gonorrhoeae isolates collected in Nanjing, China, that possessed decreased susceptibility (or resistance) to extended-spectrum cephalosporins (ESCs) were examined for ertapenem, and their sequence types determined. Ceftriaxone cefixime MICs of ≥0.125 mg/L ≥0.25 mg/L, respectively, first determined 259 strains isolated between 2013 2019, then ertapenem measured using the antimicrobial gradient Epsilometer test (Etest).
Abstract Background Likelihood of Neisseria gonorrhoeae infection in women exposed to male sex partners with increasing N. burdens and enhancement by Chlamydia trachomatis is not defined. Methods We identified men urethritis their regular female partners. Exposure was compared gonorrhoeae-infected versus -uninfected Association estimated using logistic regression. C. coinfection adjusted for linear Results In total, 1816 were enrolled; 202 had ≥2 partners, 91 who confirmed monogamy 77%...
Background: Since the first Chinese report of ceftriaxone-resistant Neisseria gonorrhoeae FC428 clone in 2016, additional FC428-like, penA 60.001 isolates have been identified China. Objective: To document rise Nanjing, China, and characterize their molecular epidemiological features. Methods: N. minimum inhibitory concentrations (MICs, mg/L) for ceftriaxone, cefixime, penicillin, tetracycline, ciprofloxacin, azithromycin, spectinomycin, gentamicin zoliflodacin were determined by agar...
Abstract Gonorrhea is one of the main sexually transmitted diseases in China. It mainly affects genitourinary tract, and its clinical manifestations vary from asymptomatic to complicated types. The diagnosis gonorrhea should be based on patient's epidemiological history, manifestations, laboratory examination results. Treatment prompt standardized involve recommended treatment regimens. Patients appropriately followed up after treatment. antimicrobial resistance gonococcal isolates has...
This study was conducted to determine the in vitro activities of gentamicin alone and combination with ceftriaxone, ertapenem, azithromycin against multidrug-resistant (MDR) Neisseria gonorrhoeae isolates. A total 407 clinical isolates from Nanjing, China, obtained 2016 2017, had MICs determined for using agar dilution method. MDR status ascribed 97 strains that displayed decreased susceptibility or resistance extended-spectrum cephalosporins (ESCs) (ceftriaxone [MIC, ≥0.125 mg/liter]...