A5004933963- Aquaculture disease management and microbiota
- Viral Infections and Vectors
- Yersinia bacterium, plague, ectoparasites research
- MicroRNA in disease regulation
- Bacteriophages and microbial interactions
- interferon and immune responses
- Microbial infections and disease research
- Identification and Quantification in Food
- Aquaculture Nutrition and Growth
- Helminth infection and control
- Invertebrate Immune Response Mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Parasite Biology and Host Interactions
- Cancer-related molecular mechanisms research
- Vibrio bacteria research studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Radiomics and Machine Learning in Medical Imaging
- Parasitic Diseases Research and Treatment
- Plant-based Medicinal Research
- Circular RNAs in diseases
- Reproductive biology and impacts on aquatic species
- Aquatic life and conservation
- Physiological and biochemical adaptations
- Advanced biosensing and bioanalysis techniques
- RNA regulation and disease
Chinese Academy of Fishery Sciences
2016-2025
Heilongjiang Institute of Technology
2024
Capital Medical University
2008-2022
Beijing Institute of Neurosurgery
2008-2022
Beijing Tian Tan Hospital
2009-2022
Northeast Agricultural University
2021
Sanya Central Hospital
2020
Sun Yat-sen University
2012
Air Force Medical University
2010
Institute of Genetics and Developmental Biology
2003
The presence of intermuscular bones severely affects the edibility and value-added processing crucian carp (Carassius auratus), becoming a constraint to high-quality development its industry. Our previous study identified bmp6 as key osteogenic regulator successfully developed new strain lacking (WUCI) using CRISPR/Cas9 technology. To accelerate industrialization, we comprehensively assessed WUCI’s growth performance, hematological parameters, antioxidant capacity, innate immunity, disease...
Background: As a broad-spectrum fluoroquinolone, enrofloxacin (ENR) is commonly employed to manage bacterial infections in aquatic species. Nevertheless, there have been no documented pharmacokinetic and residue studies conducted on Dybowski’s frog (Rana dybowskii). Therefore, the objective of our study was characterize pharmacokinetics (PK) ENR its metabolite ciprofloxacin (CIP) R. dybowskii, establish withdrawal times, evaluate physiological effects associated with administration. Methods:...
Abstract Background Yersinia ruckeri is a pathogen that can cause enteric redmouth disease in salmonid species, damaging global production of economically important fish including rainbow trout ( Oncorhynchus mykiss ). Herein, we conducted the transcriptomic profiling spleen samples from at 24 h post- Y. infection via RNA-seq an effort to more fully understand their immunological responses. Results We identified 2498 differentially expressed genes (DEGs), which 2083 and 415 were up-...
Abstract Genetic leukoencephalopathies (gLEs) are a highly heterogeneous group of rare genetic disorders. The spectrum gLEs varies among patients different ages. Distinct from the relatively more abundant studies in children, only few that explore adult have been published, and it should be noted majority these excluded certain gLEs. Thus, to date, no large study has designed conducted characterize phenotypic spectra patients. We recruited consecutive series 309 clinically suspected Beijing...
Reconstruction after intercalary excision of tibia malignancy is challenging. The combined use a vascularized fibular flap and allograft can provide reliable reconstructive option. Eight patients underwent reconstruction with an fibula following resection. Patients were examined clinically radiographically. average age was 16.5 years. mean follow-up time 38.4 months. Contralateral free used in three ipsilateral pedicle five. length defect 11.8 cm 15.9 cm. Primary union achieved seven...
Induced neural stem cells (iNSCs) can be directly transdifferentiated from somatic cells. One potential clinical application of the iNSCs is for nerve regeneration. However, it unknown whether function in disease models. We produced by conditional overexpressing Oct4, Sox2, Klf4, c-Mycin mouse embryonic fibroblasts. They expanded readily vitro and expressed NSC mRNA profile protein markers. These differentiated into mature astrocytes, neurons oligodendrocytes vitro. Importantly, they reduced...
Flavobacterium psychrophilum, the etiological agent of bacterial coldwater disease (BCWD) and rainbow trout fry syndrome, causes great economic losses in salmonid aquaculture worldwide. Recent molecular studies have uncovered important epidemiological ecological aspects this pathogen; however, such data are lacking for F. psychrophilum populations affecting China. Herein, phenotype, genotype, virulence were characterized isolates recovered from epizootics multiple facilities across...
Abstract A major hurdle for effective stem cell therapy is ongoing inflammation in the target organ. Reconditioning lesion microenvironment may be an way to promote therapy. In this study, we showed that engineered neural cells (NSCs) with complement factor H–related protein 1, a inhibitor protein, can attenuate inflammatory infiltration and immune-mediated damage of astrocytes, important pathogenic progress patients neuromyelitis optica spectrum disorders. Furthermore, demonstrated...
Objectives Seizure is a common presenting symptom of primary brain tumors. There are no published studies regarding the roles MicroRNA (miRNA) in tumor-related epilepsy. The authors set out to correlate miR-196b expression low-grade glioma patients with pre-operative seizures and post-operative seizure control. Methods Twenty-three WHO grade II astrocytomas 83 similar for independent validation were included. Follow-up visits prognosis scheduled at 6 months. MiRNA profiling was used identify...
Abstract Yersinia ruckeri is the causative agent of enteric redmouth disease or yersiniosis, which affects salmonids and several other species fish. However, there are no reports on characteristics pathogenicity Y. isolated from farm-raised Amur Sturgeon Acipenser schrencki. Here, we characterized strain H01 diseased in China. The phenotypic genotypic were observed, its virulence was tested by examining experimentally infected sturgeons. Examination flagellar morphology transmission electron...
// Yongsheng Cao 1,2 , Qiya Zhang 2 Liming Xu 1 Shaowu Li Di Wang Jingzhuang Zhao Hongbai Liu Jian Feng 3 and Tongyan Lu Heilongjiang River Fishery Research Institute of Chinese Academy Sciences, Harbin, China State Key Laboratory Freshwater Ecology Biotechnology, Hydrobiology, Wuhan, Benxi Agrimarine Company Limited, Benxi, Correspondence to: Lu, email: Zhang, Keywords : rainbow trout; cytokines; adjuvant; DNA vaccine; protection; Immune response; Immunology Received June 01, 2017 Accepted...
Introduction Pike perch ( Sander Lucioperca ) is a predatory freshwater fish, which highly popular amongst consumers, owing to its white flesh with delicate structure and mild flavor. Compared wild pike perch, the diet of farmed ones has shifted from natural food artificial feeds. These changes would affect gut flora perch. Endogenous metabolites intestinal are transferred through gut-liver axis, affects physiological functions host. By studying individuals novel insights into stability can...