A5018748154- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Metal complexes synthesis and properties
- Ferrocene Chemistry and Applications
- Organometallic Complex Synthesis and Catalysis
- Lanthanide and Transition Metal Complexes
- Supramolecular Chemistry and Complexes
- Fluorine in Organic Chemistry
- Molecular Sensors and Ion Detection
- Chemical Synthesis and Analysis
- Carbon dioxide utilization in catalysis
- Magnetism in coordination complexes
- Inorganic Fluorides and Related Compounds
- Catalytic C–H Functionalization Methods
- Chemical Reaction Mechanisms
- Metal-Organic Frameworks: Synthesis and Applications
- Glycosylation and Glycoproteins Research
- Polymer composites and self-healing
- Microwave-Assisted Synthesis and Applications
- Synthesis and Catalytic Reactions
- Mass Spectrometry Techniques and Applications
- Vanadium and Halogenation Chemistry
- Advanced NMR Techniques and Applications
- Oxidative Organic Chemistry Reactions
University of Warwick
2013-2024
Coventry (United Kingdom)
2015-2018
University of Oxford
2006-2009
University of St Andrews
2002-2006
University College London
2006
University of Glasgow
2006
University of Exeter
2002-2006
Comenius University Bratislava
1994-1996
Cyclic adenosine diphosphate (ADP)–ribose (cADPR) isomers are signaling molecules produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via nicotinamide adenine dinucleotide (oxidized form) (NAD + ) hydrolysis. We show that v-cADPR (2′cADPR) v2-cADPR (3′cADPR) cyclized O-glycosidic bond formation between the ribose moieties in ADPR. Structures of 2′cADPR-producing TIR reveal conformational changes lead to an active assembly resembles those Toll-like adaptor domains....
Lasso peptides are ribosomally synthesized and post-translationally modified (RiPPs) that possess a unique "lariat knot" structural motif. Genome mining-targeted discovery of new natural products from microbes obtained extreme environments has led to the identification gene cluster directing biosynthesis lasso peptide, designated as chaxapeptin 1, in genome Streptomyces leeuwenhoekii strain C58 isolated Atacama Desert. Subsequently, 1 was characterized using high-resolution electrospray...
Abstract An improved method for the synthesis of tethered ruthenium(II) complexes monosulfonylated diamines is described, together with their application to hydrogenation ketones and aldehydes. The were applied directly, in chloride form, asymmetric ketone hydrogenation, give products excess 99% ee best cases, using 30 bar hydrogen at 60 °C, selective reduction aldehydes over other functional groups.
A ferrocene-based ditopic receptor containing a urea and benzocrown ether unit shows remarkable colour switching (ON-and-OFF) function induced by anion cation recognition.
Half-sandwich Rh<sup>III</sup> anticancer complexes with activated Cp* rings not only undergo sequential CH<sub>3</sub> H–D exchange, but also react biological dienes, generating Rh<sup>I</sup> Diels–Alder adducts in aqueous media at ambient temperature.
Silicon anodes require polymer binder systems that are both mechanically robust and electrochemically stable, to accommodate the dramatic volume expansion experienced during cycling operation. Herein, we report use of a poly(acrylic acid)-grafted styrene–butadiene rubber (PAA-g-SBR) with 80% partially neutralized Na-PAA as system for silicon-graphite anodes. The PAA-g-SBR graft copolymer was synthesized by grafting tert-butyl acrylate onto SBR treating intermediate H3PO4. PAA-g-SBR/Na-PAA...
Thermoresponsive polymers have attracted huge interest as a way of developing smart/adaptable materials for biomedicine, particularly due to changes in their solubility above the LCST. However, temperature is not always an appropriate or desirable stimulus given variety other cellular microenvironments that exist, including pH, redox potentials, ionic strength, and metal ion concentration. Here, we achieve highly specific, isothermal switch poly(N-isopropylacrylamide) by application ferric...
Mycobacterium tuberculosis ( Mtb ), the aetiological agent of tuberculosis, has evolved to scavenge nutrients from confined environment host macrophages with mycobacterial ATP-binding cassette (ABC) transporters playing a key role in nutrient acquisition. -UspC (Rv2318) is solute-binding protein essential transporter UspABC, one four ABC implicated by homology sugar Herein, we report structural and functional characterization -UspC. The 1.5 Å resolution structure UspC reveals two subdomain...
A new strategy for the asymmetric synthesis of chiral primary alpha-ferrocenylalkylamines has been utilized to generate homochiral redox-active receptors that bind carboxylate anions with moderate enantioselectivity and undergo a redox response complexation. [structure: see text]
A method for probing the strength of B–N dative bonds is reported. The activation parameters nitrogen inversion in a series azetidines tethered to boronate esters have been quantified by VT-NMR and measured barriers correlated with data obtained 11B NMR, X-ray crystallography MP2 calculations.
Combination of four well-established techniques complemented with temperature dependence for probing structural changes and detecting differences between insulin samples.
A water-soluble fluorine magnetic resonance spectroscopy host-guest probe, P(HPA-co-AdamCF3A), was successfully constructed from the facile synthesis of a bifunctional monomer via quantitative Passerini reaction. Supramolecular complexation with (2-hydroxypropyl)-β-cyclodextrin promoted change in chemical environment, leading to modulation both relaxation properties as well shift moieties. This used probe supramolecular interaction by 19F MRI and give insight into formulation. work provides...
Sulfonyl ethylenediamine Ru( ii ) arene transfer hydrogenation catalysts can have high anticancer activity, but react rapidly with thiols, forming bridged dinuclear complexes.
A series of 18-electron complexes general formula [Ru(p-cym)(1,2-dicarba-closo-dodecaborane-1,2-dithiolato)(L)] (p-cym = para-cymene; L 4-dimethylaminopyridine (2), nicotinamide (3), 3-ethynylpyridine (4), N-methylimidazole (5), 4-cyanopyridine (6), and pyridine (7)) were synthesised by reactions between the 16-electron precursor [Ru(p-cym)(1,2-dicarba-closo-dodecaborane-1,2-dithiolato)] (1) corresponding heterocyclic bases. X-ray crystal structures 2 5 determined. In dichloromethane...
Abstract Dinuclear trihydroxido‐bridged osmium–arene complexes are inert and biologically inactive, but we show here that linking dihydroxido‐bridged Os II –arene fragments by a bridging di‐imine to form metallacycle framework results in strong antiproliferative activity towards cancer cells distinctive knotting of DNA. The shortened spacer length reduces biological stability solution decomposition inactive dimers. Significant differences behavior toward plasmid DNA condensation correlated...
Four verdazyl radicals, with varying substituents at the 3-position, were synthesised and used to prepare unimolecular initiators for use in stable free radical mediated living polymerisation of styrene n-butyl acrylate. The addition bulky differing electronic structures 3-position ring was investigated effects these on properties studied. nature substituent discovered affect rate characteristics polymerisation. acrylate homopolymers chain extended provide evidence as end group polymers.
Interaction of the reactive 14 VE {Ir(IBioxMe4)3}(+) fragment with fluoroarenes results exclusively in ortho-C-H bond oxidative addition and formation 16 Ir(iii) derivatives [Ir(IBioxMe4)3(Ar)H](+) (Ar = 2-C6H4F, 2,3-C6H3F2, 2,4,6-C6H2F3). The C-H activation reactions occur under mild conditions are reversible.
New insights on the impact of hydrogen bonding and electrostatic interactions temperature-dependencies self-healing electromechanical properties dielectric elastomers.
A strong 11B {1H} nuclear Overhauser effect (NOE) enhancement can be observed in solid-state NMR spectra of borane adducts, yielding fractional enhancements, fI{S} = (I − I0)/I0, the magic angle spinning (MAS) signal up to 155%. This is an interesting and unusual observation as (spin I 3/2) a quadrupolar nucleus corresponding NOE completely absent solution. More generally, it shows that may have wider role play studies dynamics than has been envisaged hitherto.
The synthesis and characterization of five-coordinate rhodium(III) iridium(III) complexes the form [M(PNP-Np)(biph)][BArF4] are described, where PNP-Np is neopentyl-substituted pincer ligand 2,6-(Np2PCH2)2C5H3N (Np = CH2tBu), biph 2,2′-biphenyl, ArF 3,5-(CF3)2C6H3. These notable for adoption δ-agostic interactions in solid state, as evidenced by X-ray crystallography (50–150 K) ATR-IR spectroscopy, but structurally dynamic solution, exhibiting pseudorotation on 1H NMR time scale (185–308 K)....
Lithiation and alkylation of a 2-isopropylidineaziridine bearing an (S)-alpha-methylbenzyl group on nitrogen proceeds with high levels diastereocontrol (80-90% de).
Subnanometer-scale silicon dioxide (SiO2) films are frequently present before, during, and after device processing, yet they offer minimal surface passivation can detrimentally impact subsequent processing steps. Here we develop a process whereby the of nanometer subnanometer SiO2 is enhanced by up to 2 orders magnitude simple room temperature treatment using superacid bis(trifluoromethane)sulfonimide (TFSA, sometimes TFSI). By accurately modeling effective lifetime curves corresponding...