A5101664194- Advanced MRI Techniques and Applications
- Peripheral Nerve Disorders
- Tendon Structure and Treatment
- Advanced Neuroimaging Techniques and Applications
- Shoulder Injury and Treatment
- Osteoarthritis Treatment and Mechanisms
- Infrared Thermography in Medicine
- Knee injuries and reconstruction techniques
- Medical and Biological Sciences
- Hemophilia Treatment and Research
- Sports injuries and prevention
- Atomic and Subatomic Physics Research
- Advanced NMR Techniques and Applications
- Orthopedic Surgery and Rehabilitation
- Lower Extremity Biomechanics and Pathologies
- Head and Neck Cancer Studies
- Extracellular vesicles in disease
- Bone health and treatments
- Shoulder and Clavicle Injuries
- Shape Memory Alloy Transformations
- Cardiovascular Effects of Exercise
- MRI in cancer diagnosis
- Ultrasound and Hyperthermia Applications
- Cervical and Thoracic Myelopathy
- Cancer Genomics and Diagnostics
VA San Diego Healthcare System
2017-2023
John Wiley & Sons (United States)
2022
University of Manchester
2022
University of California, San Diego
2002-2021
University of California San Diego Medical Center
2017-2020
Monash University
2019
Monash Health
2019
University of Southern California
2013-2014
University of Hong Kong
2009
University of Michigan
2002
Background Signal contamination from long T2 water is a major challenge in direct imaging of myelin with MRI. Nulling the unwanted signals can be achieved an inversion recovery (IR) preparation pulse to null white matter within brain. The remaining ultrashort signal detected echo time (UTE) sequence. Purpose To develop patient-specific whole-brain three-dimensional double-echo sliding (DESIRE) UTE Materials and Methods DESIRE sequence generates series IR images different times during single...
Background Rotator cuff tendons (RCTs) are challenging to image due the “magic angle effect” and their short T 2 . Purpose To assess degree of magic sensitivity human RCTs utilize a 3D ultrashort echo time Cones sequence with magnetization transfer preparation (UTE‐Cones‐MT) two‐pool quantitative MT modeling histological correlation. We hypothesized that parameters would be less sensitive compared conventional measurements. Study Type Prospective imaging pathologic Specimen Twenty cadaveric...
Purpose The purpose of this study was to investigate the feasibility ultrashort echo time quantitative susceptibility mapping (UTE‐QSM) for assessment hemosiderin deposition in joints hemophilic patients. Methods UTE‐QSM technique based on three sets dual‐echo 3D UTE Cones data acquired with TEs 0.032/2.8, 0.2/3.6, and 0.4/4.4 ms. images were processed iterative decomposition water fat asymmetry least‐squares estimation estimate B 0 field map presence fat. Then, projection onto dipole (PDF)...
Abstract Conventional magnetic resonance imaging (MRI) often acquires no signal in anterior cruciate ligament (ACL) due to the short apparent transverse relaxation time of ACL. Ultrashort echo (UTE) MRI is capable ACL with high which enables quantitative assessment. This study aimed investigate correlations mechanical and microstructural properties human specimens three‐dimensional UTE Cones (3D‐UTE‐Cones) measures. were harvested from cadaveric knee joints 13 (50.9 ± 21.1 years old, 11...
Abstract Introduction Evidence suggests that toxic iron is involved in haemophilic joint destruction. Aim To determine whether deposition linked to clinical and imaging outcomes order optimize management of disease. Methods Adults with haemophilia A or B (n = 23, ≥ age 21) all severities were recruited prospectively undergo assessment Hemophilia Joint Health Scores (HJHS), pain scores (visual analogue scale [VAS]) magnetic resonance (MRI) at 3T using conventional MRI protocols 4‐echo...
Direct myelin imaging is promising for characterization of multiple sclerosis (MS) brains at diagnosis and in response to therapy. In this study, a 3D inversion recovery‐prepared ultrashort echo time cones (IR‐UTE‐Cones) sequence was used both morphological quantitative on clinical 3 T scanner. Myelin powder phantoms with different concentrations were imaged the UTE‐Cones it showed strong correlation between signals, demonstrating ability directly image brain. Quantitative multi‐echo...
Background MicroRNAs (miRNAs) are highly conserved, short (18–22 nts), non-coding RNA molecules that regulate gene expression by binding to the 3′ untranslated regions (3′UTRs) of mRNAs. While numerous cellular microRNAs have been associated with progression various diseases including cancer, miRNAs retroviruses not well characterized. Herein we report identification microRNA-like sequences in coding several HIV-1 genomes. Results Based on our earlier proteomics and bioinformatics studies,...
Joint iron accumulation is the incendiary factor triggering osteochondral destruction, synovial hypertrophy, inflammation, and vascular remodelling in haemophilic arthropathy (HA). Hemosiderin depositions have been described synovium and, more recently, cartilage. Clinical observations also suggest hemosiderin subchondral cysts, implying cyst bleeding.We explored associations between cystic accumulation, HA status to determine if bleeding may contribute progression.Thirty-six joints (16...
Ultrashort echo time (UTE) sequences can image tissues with transverse T 2 / * relaxations too short to be efficiently observed on routine clinical MRI sequences, such as the vertebral body cartilaginous endplate (CEP). Here, we describe a 3D adiabatic inversion‐recovery‐prepared fat‐saturated ultrashort (3D IR‐FS‐UTE) sequence highlight CEP of bodies in comparison intervertebral disc (IVD) and bone marrow fat (BF) at 3 T. The IR‐FS‐UTE used UTE combined an IR preparation pulse centered...
To improve the biocompatibility and bioactivity of NiTi shape memory alloy (SMA), apatite/collagen composite coatings were fabricated on surface SMA at room temperature using electrochemical deposition technique. Spherical apatite particles fibrous collagen that formed coating visible under scanning electron microscope (SEM). The Ca/P ratio component in coating, as determined by energy dispersive X-ray spectroscopy (EDX), was about 1.38 which is slightly higher than octocalcium phosphate...
The objective of the current study was to investigate feasibility quantitative 3D ultrashort echo time (UTE)‐based biomarkers in detecting proteoglycan (PG) loss and collagen degradation human cartilage. A total 104 cartilage samples were harvested for a trypsin digestion (n = 44), sequential collagenase 60), respectively. Forty‐four randomly divided into group (tryp group) control (phosphate‐buffered saline [PBS] 22 each experiment. remaining 60 equally four groups 15 digestion, including...
Peripheral nerves are a composite tissue consisting of neurovascular elements packaged within well-organized extracellular matrix. Their composition, size, and anatomy render challenging medical imaging target. In contrast to morphological MRI, which represents the predominant approach nerve imaging, quantitative MRI sequences can provide information regarding composition. Here, we applied standard clinical Carr-Purcell-Meiboom-Gill (CPMG) experimental three-dimensional (3D) ultrashort echo...
The aim of this study was to determine the association between high-density mineralized protrusions (HDMPs) and central osteophytes (COs), describe varying appearance these lesions using advanced clinical imaging a novel histological protocol. Seventeen consecutive patients with clinically knee osteoarthritis undergoing arthroplasty were included. Surgical tissues containing osteochondral region investigated computed tomography (CT); subset evaluated confocal microscopy fluorescence. Tissues...
Abstract Pelvic floor disorders negatively impact millions of women worldwide. Although there is a strong epidemiological association with childbirth, the mechanisms leading to dysfunction integral constituents female pelvic floor, including skeletal muscles, are not well understood. This in part due constraints associated directly probing these which located deep pelvis. Thus, experimental models and non‐invasive techniques essential for advancing knowledge various phenotypes muscle injury...
Quantitative MR imaging is a powerful tool for assessing biochemical changes in tissue. In this study, we propose to measure the transverse magnetization relaxation time, diffusivity, and transfer ratio whole intervertebral disc (IVD), including annulus fibrosis, cartilaginous endplate (CEP), nucleus pulposus, on 3T pre-clinical scanner. The sequence parameters were optimized high resolution signal-to-noise mapping, utilizing high-performance gradient system scanner, echo times sufficiently...
The effect of dehydration ex vivo cartilage samples and rehydration with native synovial fluid or normal saline on quantitative ultrashort echo time (UTE) biomarkers are unknown. We aimed to investigate the dehydration-rehydration UTE compare capabilities saline.A total 37 were harvested from patients (n=5) who underwent knee replacement. Fresh exposed air dehydrate for 2 hours after baseline magnetic resonance (MR) scanning, then randomly divided into two groups: one soaking in (n=17) other...
In the past, we have presented an imaging-informatics based eFolder system for managing and analyzing imaging lesion data of multiple sclerosis (MS) patients, which allows storage, analysis, mining in clinical research settings. The integrates patient's with studies a computer-aided detection (CAD) algorithm quantifying MS volume, contour, locations, sizes brain MRI studies. For compliance IHE integration protocols, long-term storage PACS, query display DICOM compliant setting, CAD results...