A5016020699- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- Sleep and Wakefulness Research
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Music Perception
- Neuroscience and Neural Engineering
- Peroxisome Proliferator-Activated Receptors
- Connexins and lens biology
- Genetics and Neurodevelopmental Disorders
- Visual perception and processing mechanisms
- Stress Responses and Cortisol
- Lysosomal Storage Disorders Research
- Heat shock proteins research
- Advanced Memory and Neural Computing
- Multisensory perception and integration
- Olfactory and Sensory Function Studies
- Hearing Loss and Rehabilitation
- Mitochondrial Function and Pathology
- Cellular transport and secretion
- Cardiac Arrest and Resuscitation
- Regulation of Appetite and Obesity
- Congenital heart defects research
Charité - Universitätsmedizin Berlin
2005-2023
Max Planck Institute of Experimental Medicine
2014-2023
Max Planck Institute for Multidisciplinary Sciences
2022-2023
Bernstein Center for Computational Neuroscience Berlin
2022-2023
Hebrew University of Jerusalem
2008-2022
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2021-2022
Max Planck Society
2014
University of Edinburgh
1998-2014
Auditory prostheses can partially restore speech comprehension when hearing fails. Sound coding with current is based on electrical stimulation of auditory neurons and has limited frequency resolution due to broad spread within the cochlea. In contrast, optical be spatially confined, which may improve resolution. Here, we used animal models characterize optogenetic stimulation, genetically engineered express light-gated ion channel channelrhodopsin-2 (ChR2). Optogenetic spiral ganglion...
Abstract Myelinating oligodendrocytes enable fast propagation of action potentials along the ensheathed axons. In addition, play diverse non-canonical roles including axonal metabolic support and activity-dependent myelination. An open question remains whether myelination also contributes to information processing in addition speeding up conduction velocity. Here, we analyze role myelin auditory using paradigms that are good predictors speech understanding humans. We compare mice with...
To maintain homeostasis, the body, including brain, reprograms its metabolism in response to altered nutrition or disease. However, consequences of these challenges for energy different brain cell types remain unknown. Here, we generated a proteome atlas major central nervous system (CNS) from young and adult mice, after feeding therapeutically relevant low-carbohydrate, high-fat ketogenic diet (KD) during neuroinflammation. Under steady-state conditions, CNS prefer distinct modes...
Abstract It has been suggested previously that 30% sparing of the hippocampus is enough to support spatial learning a reference memory task in water maze provided spared tissue located septally (Moser et al. 1995, Proc Natl Acad Sci USA 92:9697–9701). Therefore, temporal may not be involved memory. Place cells are also found this part structure, and it these place have larger, less well‐tuned fields than septal hippocampus. We tested possibility might when animals required distinguish...
When faced with sensory stimuli, an organism may be required to detect very small differences in a physical parameter (discrimination), while other situations it have generalize over many possible values of the same parameter. This decision based both on learned information and aspects perception. In present study we describe frequency processing behaving mouse using discrimination generalization as two key behaviour. We used novel naturalistic behavioural apparatus designed for mice,...
This experiment explored whether excitotoxic hippocampus plus dentate gyrus (HPC/DG) lesions in rats would dissociate the differential processing of contextual cues during performance learned associations when (1) their training is incidental to successful learning or (2) solution a discrimination problem contingent on processing. A series stages were conducted, beginning with appetitive conditioning two stimuli (X and Y), each which was trained one different contexts (operant chambers B)...
Retrograde amnesia can occur after brain damage because this disrupts sites of storage, interrupts memory consolidation, or interferes with retrieval. While the retrieval failure account has been considered in several animal studies, recent work focused mainly on and neural mechanisms responsible for reactivating from stored traces remain poorly understood. We now describe a new phenomenon which rats' spatial location watermaze was first weakened by partial lesions hippocampus to level at it...
Detecting regular patterns in the environment, a process known as statistical learning, is essential for survival. Neuronal adaptation key mechanism detection of that are continuously repeated across short (seconds to minutes) temporal windows. Here, we found mice subcortical structure auditory midbrain was sensitive were discontinuously, temporally sparse manner, windows minutes hours. Using combination behavioral, electrophysiological, and molecular approaches, changes neuronal response...
Impairment of peripheral nerve function is frequent in neurometabolic diseases, but mechanistically not well understood. Here, we report a novel disease mechanism and the finding that glial lipid metabolism critical for axon function, independent myelin itself. Surprisingly, nerves Schwann cell-specific Pex5 mutant mice were unaltered regarding numbers, axonal calibers, sheath thickness by electron microscopy. In search molecular mechanism, revealed enhanced abundance internodal expression...
The behavioral changes that comprise operant learning are associated with plasticity in early sensory cortices as well modulation of gene expression, but the connection between behavioral, electrophysiological, and molecular is only partially understood. We specifically manipulated c-Fos a hallmark learning-induced synaptic plasticity, auditory cortex adult mice using novel approach based on RNA interference. Locally blocking expression caused specific deficit sound discrimination task,...
Abnormalities in synaptic inhibition play a critical role psychiatric disorders, and accordingly, it is essential to understand the molecular mechanisms linking components of inhibitory postsynapse psychiatrically relevant neural circuits behaviors. Here we study IgSF9b, an adhesion protein that has been associated with affective amygdala anxiety circuitry. We show deletion IgSF9b normalizes anxiety-related behaviors processing mice lacking synapse organizer Neuroligin-2 (Nlgn2), which was...
Abstract This study investigated the ability of animals to learn both reference memory and delayed matching‐to‐place variants watermaze after large lesions hippocampus that deliberately spared only small remnants structure. Groups were created had differing blocks residual tissue in septal pole (15% or 30% total volume), located either unilaterally (30 50% on one side, 0% other) bilaterally + 30%). These groups capable learning task, as indexed by normal spatially focused searching a probe...
The way animals respond to a stimulus depends largely on an internal comparison between the current sensation and memory of previous stimuli outcomes. We know little about accuracy with which physical properties influence this type memory-based discriminative decisions. Research has focused discriminations presented in quick succession, where can make relative inferences (same or different; higher lower) from trial trial. In study we used task explore how stimulus' properties, case tone...
Nedd4-2 is an E3 ubiquitin ligase in which missense mutation related to familial epilepsy, indicating its critical role regulating neuronal network activity. However, substrates involved function have yet be identified. Using mouse lines lacking Nedd4-1 and Nedd4-2, we identified astrocytic channel proteins inwardly rectifying K+ 4.1 (Kir4.1) Connexin43 as substrates. We found that the expression of Kir4.1 increased upon conditional deletion astrocytes, leading elevation membrane ion...
The mammalian hippocampus is anatomically heterogeneous along its longitudinal axis, and there evidence that distinct functions are executed by different septotemporal subregions. best documented example the dependency of spatial learning on septal, but not temporal, hippocampus. Here, we carried out a watermaze memory task in rats with partial lesions septal or temporal made either before after training. We then studied retention, reversal, new novel environment. This resulted surprising...
As we interact with our surroundings, encounter the same or similar objects from different perspectives and are compelled to generalize. For example, despite their variety recognize dog barks as a distinct sound class. While have some understanding of generalization along single stimulus dimension (frequency, color), natural stimuli identifiable by combination dimensions. Measuring interaction is essential understand perception. Using 2-dimension discrimination task for mice frequency...
Learning is facilitated when information can be incorporated into an already learned set of rules or 'mental schema'. The location a new restaurant, for example, more easily if the neighbourhood's general layout known. This type processed by hippocampus and stored as schema in cortex, but it not known whether also map stimuli to cortical schemata that are hippocampus-independent, such odour classification. Using hippocampus-independent odour-rule task we found animals without functional...
Abstract Myelinating oligodendrocytes enable fast impulse propagation along axons as revealed through studies of homogeneously myelinated white matter tracts. However, gray myelination patterns are different, with sparsely sections leaving large portions the naked. The consequences this patchy for oligodendrocyte function not understood but suggest other roles in information processing beyond regulation axonal conduction velocity. Here, we analyzed contribution myelin to auditory using...