A5007409449- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Mitochondrial Function and Pathology
- Genetics and Neurodevelopmental Disorders
- Advanced MRI Techniques and Applications
- Cellular Mechanics and Interactions
- Protease and Inhibitor Mechanisms
- Tryptophan and brain disorders
- Cell Image Analysis Techniques
- Alzheimer's disease research and treatments
- Biotin and Related Studies
- Stress Responses and Cortisol
Universidade Federal do Rio Grande do Sul
2021
Max Planck Institute of Experimental Medicine
2018-2021
University of Göttingen
2021
Significance For decades, it was claimed that glucose the sole and sufficient energy substrate to sustain neuronal activity brain function. Our results challenge this view by demonstrating despite availability, lactate shuttling from astrocytes neurons via monocarboxylate transporters is necessary give rise blood oxygen level-dependent signal (used as a surrogate marker for activation) in rat cerebral cortex following whisker stimulation. Moreover, turned out be also essential sustaining...
Abnormalities in synaptic inhibition play a critical role psychiatric disorders, and accordingly, it is essential to understand the molecular mechanisms linking components of inhibitory postsynapse psychiatrically relevant neural circuits behaviors. Here we study IgSF9b, an adhesion protein that has been associated with affective amygdala anxiety circuitry. We show deletion IgSF9b normalizes anxiety-related behaviors processing mice lacking synapse organizer Neuroligin-2 (Nlgn2), which was...
While the neural circuits mediating normal, adaptive defensive behaviors have been extensively studied, substantially less is currently known about network mechanisms by which aberrant, pathological anxiety encoded in brain. Here we investigate mice how deletion of Neuroligin-2 (Nlgn2), an inhibitory synapse-specific adhesion protein that has associated with and other psychiatric disorders, alters communication between key brain regions involved behaviors. To this end, performed multi-site...
Abstract Inhibitory synaptic transmission plays a key role in the circuits underlying anxiety behaviors, but network mechanisms by which disruptions inhibition contribute to pathological processing remain largely unknown. Here we addressed this question mice lacking inhibitory synapse-specific adhesion protein Neuroligin-2 (Nlgn2), display widespread reduction as well pronounced phenotype. To investigate how lack of alters communication between brain regions processing, recorded local field...
The impact of stress on health and well-being is determined by the ability an individual to cope with challenges imposed stressor. Animals exposed social defeat show different patterns response during confrontations, leading distinct stress-induced consequences. Using established resident-intruder paradigm, we explored outcomes adopting active or passive coping strategies a protocol over peripheral central nervous system (CNS) levels inflammatory cytokines, growth factors, glucocorticoid,...
For decades, it was claimed that glucose the sole and sufficient energy substrate to sustain neuronal activity brain function. Our results challenge this view by demonstrating despite availability, lactate shuttling from astrocytes neurons via monocarboxylate transporters is necessary give rise BOLD signal in rat cerebral cortex following whisker stimulation. Moreover, turned out be also essential for sustaining behavioral performance associated with activation of barrel cortex. These...