Previous imaging studies of congenital blindness have studied individuals with heterogeneous causes blindness, which may influence the nature and extent cross-modal plasticity. Here, we scanned a homogeneous group blind people bilateral anophthalmia, condition in both eyes fail to develop, and, as result, visual pathway is not stimulated by either light or retinal waves. This model presents an opportunity investigate effects very early deafferentation on functional organization brain. In...

Positive affect and optimism play an important role in healthy ageing are associated with improved physical cognitive health outcomes. This study investigated whether it is possible to boost positive biases this age group using training. The effect of computerised imagery-based bias modification on affect, vividness prospective imagery interpretation older adults was measured. 77 received 4 weeks (12 sessions) or a control condition. They were assessed at baseline, post-training one-month...

The sources of inter- and intra-individual variability in age-related cognitive decline remain poorly understood. We examined the association between 20-year trajectories multimodal brain structure morphology older age. used Whitehall II Study, an extensively characterised cohort with 3T magnetic resonance images acquired at age (mean = 69.52 ± 4.9) 5 repeated performance assessments mid-life 53.2 ±4.9 years) late-life 67.7 4.9). Using non-negative matrix factorization, we identified 10...

With promising disease-modifying therapies (DMTs) emerging and good evidence to support risk reduction in the delay of dementia onset progression, it is important understand profile patients attending memory assessment services estimate what proportion might benefit from different types interventions. The Oxford Brain Health Clinic (OBHC) a psychiatry-led, clinical-research service that offers clinic detailed clinical assessments equal access research opportunities as part their secondary...

Introduction Despite major advances in the field of neuroscience over last three decades, quality assessments available to patients with memory problems later life has barely changed. At same time, a large proportion dementia biomarker research is conducted selected samples that often poorly reflect demographics population who present clinics. The Oxford Brain Health Clinic (BHC) newly developed clinical assessment service embedded which all are offered high-quality and assessments,...

The ability to form positive mental images may be an important aspect of health and well-being. We have previously demonstrated that the vividness prospective imagery is increased in healthy older adults following cognitive training. rostral anterior cingulate cortex (rACC) involved simulation future affective episodes. Here, we investigate effect training on rACC activity during imagination novel, ambiguous scenarios vs closely matched control Seventy-five participants received 4 weeks or...

The Oxford Brain Health Clinic (BHC) is a joint clinical-research service that provides memory clinic patients and clinicians access to high-quality assessments not routinely available, including brain MRI aligned with the UK Biobank imaging study (UKB). In this work we present how 1) adapted UKB acquisition protocol be suitable for patients, 2) modified analysis pipeline extract measures are in line radiology reports 3) explored alignment of from BHC largest world (ultimately 100,000...

Working memory (WM) is essential for normal cognitive function, but shows marked decline in aging. The importance of selective attention guiding WM performance increasingly recognized. Studies so far are inconclusive about the ability to use during To investigate neural mechanisms supporting aging, we tested a large group older adults using functional magnetic resonance imaging whilst they performed category-based (faces/houses) selective-WM task. Older were able encode targets and suppress...

Abstract The sources of inter- and intra-individual variability in age-related cognitive decline remain poorly understood. We examined the association between 20-year trajectories multimodal brain structure morphology older age. used Whitehall II Study, an extensively characterised cohort with 3T magnetic resonance images acquired at age (mean = 69.52± 4.9) 5 repeated performance assessments mid-life 53.2 ±4.9 years) late-life 67.7 ±4.9). Using non-negative matrix factorization, we...

With promising disease-modifying therapies (DMTs) emerging and good evidence to support risk reduction in the delay of dementia onset progression, it is important understand profile patients attending memory assessment services estimate what proportion might benefit from different types interventions. The Oxford Brain Health Clinic (OBHC) a psychiatry-led, clinical-research service that offers clinic detailed clinical assessments equal access research opportunities as part their secondary...

ABSTRACT Introduction Despite major advances in the field of neuroscience over last three decades, quality assessments available to patients with memory problems later life has barely changed. At same time, a large proportion dementia biomarker research is conducted selected samples that often poorly reflect demographics population who present clinics. The Oxford Brain Health Clinic (BHC) newly developed clinical assessment service embedded which all are offered high and assessments,...

Abstract Background Traumatic brain injury (TBI) has been associated with an increased risk of dementia, but the link between mild TBI across life‐course remains unclear. The PREVENT Dementia study is recruiting healthy volunteers in middle age (aged 40 – 59) to identify factors that may increase their dementia. This analysis assessed white matter integrity and its association incidence, frequency severity TBIs. Methods 140 subjects (mean age=51.9 years) from West London site underwent a 3T...

Abstract Introduction The Oxford Brain Health Centre (BHC) is an ambitious and innovative joint clinical‐research service that aims to bring UK NHS memory services into the 21 st century by addressing gaps between clinical practice research advances dementia. This NIHR‐funded partnership Foundation Trust University of will be first psychiatry‐led its kind, developing model for a specialist can adopted throughout health service. Methods Materials BHC augment current providing high‐quality...

Abstract The Oxford Brain Health Clinic (BHC) is a joint clinical-research service that provides memory clinic patients and clinicians access to high-quality assessments not routinely available, including brain MRI aligned with the UK Biobank imaging study (UKB). In this work we present how 1) adapted UKB acquisition protocol be suitable for patients, 2) modified analysis pipeline extract measures are in line radiology reports 3) compared from BHC largest world (ultimately 100,000...

Abstract Background Personalised risk reduction is a key driver for the nascent UK Brain Health Clinic (BHC) network, with increasing evidence that modifying dementia could delay or prevent disease progression. Livingston et al. (2020) demonstrated number of factors dementia, including less formal education (identified as no secondary education), excessive alcohol consumption (>21 units/week), obesity (BMI >30), depression and presence an ApoE Ɛ4 allele; whilst increased physical...

Abstract Background The sources of inter‐ and intra‐individual variability in age‐related cognitive decline remain poorly understood. We examined the association between 20‐year trajectories multimodal brain structure morphology older age. Method used Whitehall II Study, an extensively characterised cohort with 3T magnetic resonance images acquired at age (mean = 69.52 ± 4.9) 5 repeated performance assessments mid‐life 53.2 ±4.9 years) late‐life 67.7 4.9). Using non‐negative matrix...

Abstract Background Since August 2020, the Oxford Brain Health Clinic (BHC) has seen over 200 NHS memory clinic patients (O’Donoghue et al., 2022). In addition to high‐quality cognitive and lifestyle assessments opportunities for research participation, receive a clinical MRI scan (T1‐weighted, T2‐FLAIR, SWI) can consent additional scans (diffusion – dMRI, resting‐state functional rfMRI, arterial spin labelling ‐ ASL) aligned UK Biobank (Griffanti this project, we aimed automatically extract...

Abstract Background With the advent of disease modifying treatments for dementia, it is essential to restructure memory clinic services provide accurate and early diagnosis enable precision therapies recruitment clinical trials. The Oxford Brain Health Clinic (BHC) offers a comprehensive embedded research assessment in patient pathway, including research‐quality brain MRI scan (using UK Biobank protocol), well‐tolerated by patients (Griffanti et al., 2022, Neuroimage:Clinical). In this study...

Abstract Background With the advent of disease modifying treatments for dementia, it is essential to restructure memory clinic services provide accurate and early diagnosis enable precision therapies recruitment clinical trials. The Oxford Brain Health Clinic (BHC) offers a comprehensive embedded research assessment in patient pathway, including research‐quality brain MRI scan (using UK Biobank protocol), well‐tolerated by patients (Griffanti et al., 2022, Neuroimage:Clinical). In this study...

Abstract Background Since August 2020, the Oxford Brain Health Clinic (BHC) has seen over 200 NHS memory clinic patients (O’Donoghue et al., 2022). In addition to high‐quality cognitive and lifestyle assessments opportunities for research participation, receive a clinical MRI scan (T1‐weighted, T2‐FLAIR, SWI) can consent additional scans (diffusion – dMRI, resting‐state functional rfMRI, arterial spin labelling ‐ ASL) aligned UK Biobank (Griffanti this project, we aimed automatically extract...

Working memory (WM) is essential for normal cognitive function, but shows marked decline in aging. Studies have shown that the ability to attend selectively relevant information amongst competing distractors related WM capacity. The extent which deficits aging are impairments selective attention unclear. To investigate neural mechanisms supporting aging, we tested a large group of older adults using functional magnetic resonance imaging whilst they performed category-based (faces/houses)...

Abstract Background The Oxford Brain Health Centre (BHC) provides real‐world research data, aligned with the UK Biobank imaging study (UKB), routinely captured in a clinical service from patients under‐represented dementia research. In this work we present how 1) adapted UKB MRI acquisition protocol to be suitable for memory clinic patients, 2) modified analysis pipeline extract measures that are line radiology reports and 3) compare BHC biggest brain world (ultimately 100,000 participants)....

Abstract Background Launched in August 2020, the Oxford Brain Health Centre (BHC) is UK's first psychiatry‐led joint clinical‐research service providing high‐quality assessments and increasing research opportunities for patients with memory problems. By embedding NHS service, BHC aims to address gaps between clinical practice advances into dementia. This abstract describes 60 referrals from pilot. Methods Patients Foundation Trust clinics were referred assessment prior their diagnostic...