A5003588757- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Diet and metabolism studies
- Advanced MRI Techniques and Applications
- Neurological disorders and treatments
- Cognitive Science and Mapping
- Dementia and Cognitive Impairment Research
- Brain Tumor Detection and Classification
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological and metabolic disorders
- Alzheimer's disease research and treatments
- Radiomics and Machine Learning in Medical Imaging
- Ophthalmology and Eye Disorders
- Glioma Diagnosis and Treatment
- Memory and Neural Mechanisms
- Health, Environment, Cognitive Aging
- Autism Spectrum Disorder Research
- Anatomy and Medical Technology
- Neurotransmitter Receptor Influence on Behavior
- Neurological Disease Mechanisms and Treatments
- Schizophrenia research and treatment
- Cardiac Imaging and Diagnostics
- Stress Responses and Cortisol
- Cerebrovascular and Carotid Artery Diseases
Douglas Mental Health University Institute
2016-2025
McGill University
2016-2025
University of Oxford
2021-2025
Douglas College
2020-2024
Wellcome Centre for Integrative Neuroimaging
2021-2024
Warneford Hospital
2024
University of Toronto
2022
Centre for Addiction and Mental Health
2022
Honda (Japan)
2022
Keio University
2022
Brain size variation over primate evolution and human development is associated with shifts in the proportions of different brain regions. Individual can vary almost twofold among typically developing humans, but consequences this for organization remain poorly understood. Using vivo neuroimaging data from more than 3000 individuals, we find that larger brains show greater areal expansion distributed frontoparietal cortical networks related subcortical regions limbic, sensory, motor systems....
Childhood socioeconomic status (SES) impacts cognitive development and mental health, but its association with human structural brain is not yet well characterized. Here, we analyzed 1243 longitudinally acquired MRI scans from 623 youth (299 female/324 male) to investigate the relation between SES cortical subcortical morphology ages 5 25 years. We found positive associations total volumes of brain, sheet, four separate structures. These were stable 25. Surface-based shape analysis revealed...
Abstract Although multiple sclerosis has traditionally been considered a white matter disease, extensive research documents the presence and importance of grey injury including cortical deep regions. The exhibits broad range pathology is uniquely suited to study mechanisms clinical relevance tissue in using magnetic resonance techniques. Deep associated with cognitive disability. Recently, MRI characterization properties, such as thalamic volume, have tested potential trial end points...
It was recently proposed that olfaction evolved to aid navigation. Consistent with this hypothesis, olfactory identification and spatial memory are linked overlapping brain areas which include the orbitofrontal cortex hippocampus. However, relationship between these two processes has never been specifically investigated. Here, we show covaries in humans. We also found cortical thickness of left medial cortex, volume right hippocampus, predict both memory. Finally, demonstrate deficits...
Introduction: The amygdala is a brain structure involved in emotional regulation. Studies have shown that larger volumes are associated with behavioral disorders. Prenatal maternal depression structural changes the amygdala, which turn, predictive of an increase problems. Girls may be particularly vulnerable. However, it not known whether disaster-related prenatal stress (PNMS), or aspect experience (i.e., objective hardship, subjective distress, and cognitive appraisal), influences volumes....
Abstract While numerous studies have used magnetic resonance imaging (MRI) to elucidate normative age‐related trajectories in subcortical structures across the human lifespan, there exists substantial heterogeneity among different studies. Here, we investigated relationships between age and morphology (i.e., volume shape), microstructure (using T1‐weighted/T2‐weighted [T1w/T2w] signal ratio as a putative index of myelin microstructure) striatum, globus pallidus, thalamus adult lifespan using...
In this work we use non-negative matrix factorization to identify patterns of microstructural variance in the human hippocampus. We utilize high-resolution structural and diffusion magnetic resonance imaging data from Human Connectome Project query hippocampus microstructure on a multivariate, voxelwise basis. Application identifies spatial components (clusters voxels sharing similar covariance patterns), as well subject weightings (individual across microstructure). By assessing stability...
Current dementia risk scores have had limited success in consistently identifying at-risk individuals across different ages and geographical locations.
The striatum and thalamus are subcortical structures intimately involved in addiction. morphology microstructure of these have been studied murine models cocaine addiction (CA), showing an effect drug use, but also chronological age morphology. Human studies using non-invasive magnetic resonance imaging (MRI) shown inconsistencies volume changes, effect. In this exploratory study, we used MRI-based volumetric novel shape analysis, as well a fast diffusion kurtosis sequence to study the crack...
The sources of inter- and intra-individual variability in age-related cognitive decline remain poorly understood. We examined the association between 20-year trajectories multimodal brain structure morphology older age. used Whitehall II Study, an extensively characterised cohort with 3T magnetic resonance images acquired at age (mean = 69.52 ± 4.9) 5 repeated performance assessments mid-life 53.2 ±4.9 years) late-life 67.7 4.9). Using non-negative matrix factorization, we identified 10...
Brain maturation studies typically examine relationships linking a single morphometric feature with cognition, behavior, age, or other demographic characteristics. However, the coordinated spatiotemporal arrangement of morphological features across development and their associations behavior are unclear. Here, we covariation multiple cortical (cortical thickness [CT], surface area [SA], local gyrification index [GI], mean curvature [MC]) using magnetic resonance images from NIMH...
Abstract Recent studies have reported early cerebellar and subcortical impact in the disease progression of genetic frontotemporal dementia (FTD) due to microtubule‐associated protein tau ( MAPT ), progranulin GRN ) chromosome 9 open reading frame 72 C9orf72 ). However, cerebello‐subcortical circuitry FTD has been understudied despite its essential role cognition behaviors related symptomatology. The present study aims investigate association between atrophy, neuropsychiatric symptoms across...
Abstract Previous work from our group demonstrated the use of multiple input atlases to a modified multi-atlas framework (MAGeT-Brain) improve subject-based segmentation accuracy. Currently, striatum, globus pallidus and thalamus are generated single high-resolution -contrast MRI atlas derived annotated serial histological sections. Here, we warp this five templates create de novo atlases. The overall goal is these newly warped as MAGeT-Brain in an effort consolidate workflow presented...
The hippocampus has been extensively studied in various neuropsychiatric disorders throughout the lifespan. However, inconsistent results have reported with respect to which subfield volumes are most related age. Here, we investigate whether these discrepancies may be explained by experimental design differences that exist between studies. Multiple datasets were used collect 1690 magnetic resonance scans from healthy individuals aged 18–95 years old. Standard T1-weighted (T1w; MPRAGE...
The study of the hippocampus across healthy adult lifespan has rendered inconsistent findings. While volumetric measurements have often been a popular technique for analysis, more advanced morphometric techniques demonstrated compelling results that highlight importance and improved specificity shape-based measures. Here, MAGeT Brain algorithm was applied on 134 individuals aged 18–81 years old to extract hippocampal subfield volumes shape measurements, namely: local surface area (SA)...
Abstract Despite known sex differences in human synucleinopathies such as Parkinson’s disease, the impact of on alpha-synuclein pathology mouse models has been largely overlooked. To address this need, we examine whole brain signatures neurodegeneration due to aSyn toxicity M83 model using longitudinal magnetic resonance imaging (MRI; T1-weighted; 100 μm 3 isotropic voxel; -7, 30, 90 and 120 days post-injection [dpi]; n ≥ 8 mice/group/sex/time point). initiate spreading, mice are inoculated...
The hippocampus is a critical brain structure supporting memory encoding and retrieval, yet the development of its microstructure in humans remains unknown. Understanding this may provide insight into mechanisms underlying their disruption disease. To address this, we non-invasively estimated density branching complexity neurite (dendrites, axons, glial processes) using diffusion-weighted MRI 364 participants aged 8–21. With development, large increases persisted until ~15 years age before...
Previous studies have highlighted that decreased hippocampal volume, an early neural correlate of dementia, is commonly observed in patients with mild cognitive impairment (MCI). However, it unclear whether neurodegenerative and resultant clinical trajectories are accelerated MCI concomitant depressive symptoms, leading to a faster conversion dementia stages than those who not depressed. No longitudinal study has investigated depressed amnestic (DEP+aMCI) show earlier onset progression...
Episodic memory impairment is a consistent, pronounced deficit in pre-clinical stages of late-onset Alzheimer's disease (AD). Individuals with risk factors for AD exhibit altered brain function several decades prior to the onset AD-related symptoms. In current event-related fMRI study spatial context we tested hypothesis that middle-aged adults (MA; 40–58 yrs) family history late (MA+ FH), or combined + FH and apolipoprotein E ε4 allele APOE4), will differences encoding retrieval-related...
The striatum is a major subcortical connection hub that has been heavily implicated in wide array of motor and cognitive functions. Here, we developed normative multimodal, data-driven microstructural parcellation the using non-negative matrix factorization (NMF) based on multiple magnetic resonance imaging-based metrics (mean diffusivity, fractional anisotropy, ratio between T1- T2-weighted structural scans) from Human Connectome Project Young Adult dataset (n = 329 unrelated participants,...