A5085460555- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Dementia and Cognitive Impairment Research
- Health, Environment, Cognitive Aging
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
McGill University
2022-2024
Montreal Neurological Institute and Hospital
2023-2024
Douglas Mental Health University Institute
2022-2023
Abstract Associations between brain and obesity are bidirectional: changes in structure function underpin over-eating, while chronic adiposity leads to atrophy. Investigating brain-obesity interactions across the lifespan can help better understand these relationships. This study explores interaction cortical morphometry children, young adults, older adults. We also investigate genetic, neurochemical, cognitive correlates of associations. Our findings reveal a pattern lower thickness...
Brain maturation studies typically examine relationships linking a single morphometric feature with cognition, behavior, age, or other demographic characteristics. However, the coordinated spatiotemporal arrangement of morphological features across development and their associations behavior are unclear. Here, we covariation multiple cortical (cortical thickness [CT], surface area [SA], local gyrification index [GI], mean curvature [MC]) using magnetic resonance images from NIMH...
Statistical effects of cortical metrics derived from standard T1- and T2-weighted magnetic resonance imaging (MRI) images, such as gray-white matter contrast (GWC), boundary sharpness coefficient (BSC), T1-weighted/T2-weighted ratio (T1w/T2w), thickness (CT), are often interpreted representing or being influenced by intracortical myelin content with little empirical evidence to justify these interpretations. We first examined spatial correspondence more biologically specific microstructural...
White matter hyperintensities are radiological abnormalities reflecting cerebrovascular dysfunction detectable using MRI. often present in individuals at the later stages of lifespan and prodromal Alzheimer's disease spectrum. Tissue alterations underlying white may include demyelination, inflammation oedema, but these highly variable by neuroanatomical location between individuals. There is a crucial need to characterize hyperintensity tissue vivo improve prognosis and, potentially,...
Abstract White matter hyperintensities (WMHs) are clinically significant MRI abnormalities often detected in the elderly and early stages of Alzheimer’s Disease. They indicative vascular pathology but represent a mixture microstructural tissue alterations that is highly variable between individuals. To better understand these alterations, we leveraged signal different contrasts sampled within WMHs, which have differential sensitivity to properties. Subsequently, sought examine asso WMH...
Abstract Understanding the relationship between structural and functional architecture of human brain remains a key question in neuroscience. In this regard variation cortical myelin may provide insights into organization. Previous findings have demonstrated that regions sharing myeloarchitectonic features are also likely to be structurally functionally connected. However, association is not uniform for all regions. For example, strength association, or ‘coupling’, microstructure function...
Abstract Brain maturation studies typically examine relationships linking a single morphometric feature with aspects of cognition, behavior, age, or other demographic characteristics. However, the coordinated spatiotemporal arrangement morphological features across development and their associations behavior are unclear. Here, we covariation multiple cortical (cortical thickness [CT], surface area [SA], local gyrification index [GI], mean curvature [MC]) using magnetic resonance images from...