A5074198140- Multiple Sclerosis Research Studies
- Advanced Neuroimaging Techniques and Applications
- Polyomavirus and related diseases
- Ultrasound and Hyperthermia Applications
- Peripheral Neuropathies and Disorders
- Advanced MRI Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Bacterial Infections and Vaccines
- Ultrasound Imaging and Elastography
- Systemic Lupus Erythematosus Research
- Ocular Diseases and Behçet’s Syndrome
- Brain Metastases and Treatment
- Atmospheric chemistry and aerosols
- Functional Brain Connectivity Studies
- Fungal Infections and Studies
- Air Quality and Health Impacts
- Plant responses to elevated CO2
- Cardiac Arrest and Resuscitation
- Simulation-Based Education in Healthcare
- Radiomics and Machine Learning in Medical Imaging
- Neurogenesis and neuroplasticity mechanisms
- Climate Change Policy and Economics
- Retinal and Optic Conditions
- Anesthesia and Pain Management
- Bone and Joint Diseases
Boston Medical Center
2025
University of Maryland, Baltimore
2015-2024
Baltimore VA Medical Center
2021-2024
VA Maryland Health Care System
2023-2024
University of Baltimore
2022-2024
Mass General Brigham
2024
George Mason University
2023-2024
Harvard University
2021-2023
Veterans Health Administration
2023
Brigham and Women's Hospital
2021-2023
Transplant recipients are at risk of developing progressive multifocal leukoencephalopathy (PML), a rare demyelinating disorder caused by oligodendrocyte destruction JC virus.Reports PML following transplantation were found using PubMed Entrez (1958-July 2010). A multicenter, retrospective cohort study also identified all cases among transplant diagnosed Mayo Clinic, Johns Hopkins University, Washington and Amsterdam Academic Medical Center. At 1 institution, the incidence...
Cortical lesions (CLs) contribute to physical and cognitive disability in multiple sclerosis (MS). Accurate methods for visualization of CLs are necessary future clinical studies therapeutic trials MS.
Inflammatory demyelination and axon damage in the corpus callosum are prominent features of multiple sclerosis (MS) may partially account for impaired performance on complex tasks. The objective this article was to characterize quantitative callosal MRI abnormalities their association with disability. In 69 participants MS 29 healthy volunteers, lesional extralesional indices were estimated via diffusion tensor tractography. expanded disability status scale (EDSS) functional composite (MSFC)...
Perform an investigation of the frequency and distribution leptomeningeal enhancement on postgadolinium magnetization-prepared FLAIR (MPFLAIR) in multiple sclerosis (MS) 7 Tesla (7T) MRI to relate this finding measures brain structure lesion volumes.Twenty-nine participants with MS underwent 7T brain. Three healthy volunteers (HVs) were scanned for comparison. Areas postcontrast identified. Images segmented volumes. The relationship between clinical volumetric data was explored.Two patterns...
Abstract Although multiple sclerosis has traditionally been considered a white matter disease, extensive research documents the presence and importance of grey injury including cortical deep regions. The exhibits broad range pathology is uniquely suited to study mechanisms clinical relevance tissue in using magnetic resonance techniques. Deep associated with cognitive disability. Recently, MRI characterization properties, such as thalamic volume, have tested potential trial end points...
Brain atrophy is a well-accepted imaging biomarker of multiple sclerosis (MS) that partially correlates with both physical disability and cognitive impairment.Based on MRI scans 60 MS cases 37 healthy volunteers, we measured the volumes white matter (WM) lesions, cortical gray (GM), cerebral WM, caudate nucleus, putamen, thalamus, ventricles, brainstem using validated completely automated segmentation method. We correlated these Expanded Disability Status Scale (EDSS), Severity (MSSS),...
Recent magnetic resonance imaging (MRI) studies have revealed heterogeneous susceptibility contrasts in multiple sclerosis (MS) lesions. Due to its sensitivity disease-related iron and myelin changes, susceptibility-based measures may better reflect some pathological features of MS Hence, we sought characterize lesions using combined R2* mapping quantitative (QSM).In all, 306 were selected from 24 patients who underwent 7T MRI. Maps R2*, frequency, calculated acquired multiecho gradient echo...
<h3>BACKGROUND AND PURPOSE:</h3> Susceptibility MR imaging contrast variations reflect alterations in brain iron and myelin content, making this tool relevant to studies of multiple sclerosis lesion heterogeneity. In study, we aimed characterize the relationship high-field, susceptibility contrasts lesions clinical outcomes. <h3>MATERIALS METHODS:</h3> Twenty-four subjects with underwent 7T brain, disability examinations, a fatigue inventory. The inverse T2* relaxation time (R2*), frequency,...
To estimate longitudinal changes in a quantitative whole-brain and tract-specific MRI study of multiple sclerosis (MS), with the intent assessing feasibility this approach clinical trials.A total 78 individuals MS underwent median 3 scans over 2 years. Diffusion tensor imaging indices, magnetization transfer ratio, T2 relaxation time were analyzed supratentorial brain, corpus callosum, optic radiations, corticospinal tracts by atlas-based tractography. Linear mixed-effect models estimated...
The review describes the progress of research on aqueous interphases within rechargeable zinc metal batteries.
The analgesic efficacy and adverse effects of morphine oxymorphone in 32 patients who received traditional patient-controlled analgesia (PCA) following cesarean delivery were compared with those other receiving the same agents via PCA plus basal opioid infusion (PCA + BI). All operated upon during epidural anesthesia 2% lidocaine 1:200,000 epinephrine to achieve a T4 sensory level. Upon first complaint pain recovery room, given titrated iv loading dose assigned until comfortable then...
Sensitive and specific in vivo measures of axonal damage, an important determinant clinical status multiple sclerosis (MS), might greatly benefit prognostication therapy assessment. Diffusion tensor spectroscopy (DTS) combines features diffusion imaging magnetic resonance spectroscopy, allowing measurement the properties intracellular, cell-type-specific metabolites. As such, it may be sensitive to disruption tissue microstructure within neurons. In this cross-sectional pilot study, neuronal...
Objective: Pathology in both cortex and deep gray matter contribute to disability multiple sclerosis (MS). We used the increased signal-to-noise ratio of 7-tesla (7T) MRI visualize small lesions within thalamus relate this clinical information cortical lesions. Methods: obtained 7T scans on 34 MS cases 15 healthy volunteers. Thalamic lesion number volume were related demographic data, measures, matter. Results: found 24/34 cases. Two subtypes noted: discrete, ovoid lesions, more diffuse...
Background: Autopsy data suggest a causative link between meningeal inflammation and cortical lesions (CLs) in multiple sclerosis (MS). Objective: To use leptomeningeal enhancement (LME) CLs on 7-Tesla (7T) magnetic resonance imaging (MRI) to investigate associations pathology. Methods: Forty-one participants with MS underwent 7T MRI of the brain. foci LME were quantified. Results: All had CLs; 27 (65.8%) >1 focus LME. Except for hippocampal CL count (ρ = 0.32 spread/fill-sulcal pattern...
Background Paramagnetic rim lesions (PRLs) are associated with chronic inflammation in multiple sclerosis (MS). 7‐Tesla (7T) magnetic resonance imaging (MRI) can evaluate the integrity of blood‐brain barrier (BBB) addition to tissue myelination status and cell loss. Purpose To use MRI metrics investigate underlying physiology clinical importance PRLs. Study Type Prospective. Subjects Thirty‐six participants (mean‐age 47, 23 females, 13 males) mixed MS subtypes. Field Strength/Sequence 7T,...
Vitamin D is important for bone health and immune regulation, has been shown to be low in multiple sclerosis (MS). We sought determine the effect of over counter dose cholecalciferol (LDC) high ergocalciferol (HDE) on vitamin levels MS patients.We retrospectively evaluated serum 25-hydroxy-vitamin [25(OH)D] 199 patients (CIS, n = 32; RRMS, 115; PPMS, 10; SPMS, 16; Transverse Myelitis (TM), 9; other neurological diseases, 16) attending our clinic between 2004 2008. examined change 25(OH)D 40...
This case series highlights our experience with use of the Fungitell assay for quantifying (1,3)-β-d-glucan in cerebrospinal fluid during current U.S. outbreak fungal meningitis related to contaminated methylprednisolone acetate. test may prove a useful adjunct diagnosis and management exposed patients.
Preliminary research has demonstrated that postgadolinium 3D-FLAIR MR imaging at 7T may be a valuable tool for detecting abnormal meningeal enhancement and inflammation in MS; however, researchers have not systematically investigated its longitudinal persistence. We hypothesized persistence of MS varies on the basis pattern as well demographic clinical factors such treatment status, disease phenotype, disability score.Thirty-one subjects with were prospectively scanned before after...
Although 7 T MRI research has contributed much to our understanding of multiple sclerosis (MS) pathology, most prior data come from small, single-center studies with varying methods. In order truly know if such findings have widespread applicability, multicenter methods and are needed. To address this, members the North American Imaging in MS (NAIMS) Cooperative worked together create a collaborative study MS. this manuscript, we describe developed for purpose pooling large, retrospective...