A5088316297- Statistical Methods and Inference
- Statistical Methods and Bayesian Inference
- Advanced Causal Inference Techniques
- SARS-CoV-2 and COVID-19 Research
- Statistical Methods in Clinical Trials
- Vaccine Coverage and Hesitancy
- Bayesian Methods and Mixture Models
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Control Systems and Identification
- HIV Research and Treatment
- Gaussian Processes and Bayesian Inference
- Advanced Statistical Methods and Models
- Air Quality and Health Impacts
- Health Systems, Economic Evaluations, Quality of Life
- Migration, Health and Trauma
- Machine Learning and Data Classification
- Viral Infections and Immunology Research
- Radiology practices and education
- vaccines and immunoinformatics approaches
- Respiratory viral infections research
- Noise Effects and Management
- Explainable Artificial Intelligence (XAI)
- Probabilistic and Robust Engineering Design
- Markov Chains and Monte Carlo Methods
University of Washington
2016-2025
Fred Hutch Cancer Center
2018-2024
Cancer Research And Biostatistics
2024
Seattle University
2016-2023
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2021-2022
Seattle Children's Hospital
2022
University of Nebraska Medical Center
2022
Children's Hospital & Medical Center
2022
Cancer Research Center
2018-2021
Infectious Disease Research Institute
2018-2021
Celiac plexus neurolysis (CPN) is currently used as salvage therapy for morphine-resistant pancreatic cancer pain. Endoscopic ultrasound-guided CPN (EUS-CPN) can be performed early, at the time of EUS. We hypothesized that early EUS-CPN would reduce pain and morphine consumption, increase quality life (QOL), prolong survival.Patients were eligible if referred EUS suspected with related If EUS-guided fine-needle aspiration cytology confirmed inoperable adenocarcinoma, patients randomly...
<h3>Objective:</h3> To assess the practices and perceptions of brain death determination worldwide analyze extent nature variations among countries. <h3>Methods:</h3> An electronic survey was distributed globally to physicians with expertise in neurocritical care, neurology, or related disciplines who would encounter patients at risk death. <h3>Results:</h3> Most countries (n = 91, response rate 76%) reported a legal provision 63, 70%) an institutional protocol 70, 77%) for Institutional...
Transplant recipients are at risk of developing progressive multifocal leukoencephalopathy (PML), a rare demyelinating disorder caused by oligodendrocyte destruction JC virus.Reports PML following transplantation were found using PubMed Entrez (1958-July 2010). A multicenter, retrospective cohort study also identified all cases among transplant diagnosed Mayo Clinic, Johns Hopkins University, Washington and Amsterdam Academic Medical Center. At 1 institution, the incidence...
Summary Doubly robust estimators are widely used to draw inference about the average effect of a treatment. Such consistent for interest if either one two nuisance parameters is consistently estimated. However, flexible, data-adaptive these used, double robustness does not readily extend inference. We present general theoretical study behaviour doubly an treatment when inconsistently contrast different methods constructing such and investigate extent which they may be modified also allow...
<h3>Objective:</h3> To analyze the range of demographic, clinical, MRI, and CSF features acute disseminated encephalomyelitis (ADEM), a rare, typically monophasic demyelinating disorder, long-term outcomes including time risk factors for subsequent clinical events as well competing diagnoses. <h3>Methods:</h3> We performed retrospective, multicenter study in 4 US academic medical centers all patients clinically diagnosed with ADEM. Initial presentation pediatric adult ADEM multiphasic...
Several vaccine candidates to protect against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or disease 2019 (COVID-19) have entered will soon enter large-scale, phase 3, placebo-controlled randomized clinical trials. To facilitate harmonized evaluation and comparison of the efficacy these vaccines, a general set endpoints is proposed, along with considerations guide selection primary on basis statistical reasoning. The plausibility that protection symptomatic...
Abstract In a regression setting, it is often of interest to quantify the importance various features in predicting response. Commonly, variable measure used determined by technique employed. For this reason, practitioners only resort one few techniques for which naturally defined. Unfortunately, these are suboptimal Additionally, because measures native different generally have interpretation, comparisons across can be difficult. work, we study that with any technique, and whose...
Background: Air pollution may be associated with elevated dementia risk. Prior research has limitations that affect reliability, and no studies have evaluated this question in a population-based cohort of men women the United States. Objectives: We association between time-varying, 10-y average fine particulate matter (PM2.5) exposure hazard all-cause dementia. An additional goal was to understand how adequately control for age calendar-time-related confounding through choice time axis...
Hearing and vision problems are individually associated with increased dementia risk, but the impact of having concurrent hearing deficits, ie, dual sensory impairment (DSI), on risk dementia, including its major subtypes Alzheimer disease (AD) vascular (VaD), is not well known.To evaluate whether DSI incident in older adults.This prospective cohort study from Cardiovascular Health Study (CHS) was conducted between 1992 1999, as many 8 years follow-up. The multicenter, population-based...
The best assay or marker to define mRNA-1273 vaccine–induced antibodies as a correlate of protection (CoP) is unclear. In the COVE trial, participants received two doses COVID-19 vaccine placebo. We previously assessed IgG binding spike protein (spike IgG) receptor domain (RBD and pseudovirus neutralizing antibody 50 80% inhibitory dilution titer measured on day 29 57, correlates risk (CoRs) CoPs against symptomatic over 4 months after dose. Here, we new marker, live virus 50%...
Human metapneumovirus (hMPV) is an important cause of respiratory illness. However, information about hMPV incidence, patient characteristics, and symptoms outside hospital settings limited. During June 2022-March 2024, participants aged 6 months-49 years who were enrolled in the CASCADIA community-based cohort study submitted weekly illness surveys nasal swabs, completed follow-up surveys. Swabs collected 0-3 days before reporting new or worsening tested for other viruses by multiplex...
To assess the patient care benefit of a recently implemented institutional policy requiring official second-opinion consultation for all studies performed outside institution.The review board approved retrospective data this HIPAA-compliant study and waived need individual informed consent. The reports neuroradiology finalized by subspecialty-trained neuroradiologists within calendar year 2008 were compared with provided images. categorized using five-point scale: 1 indicated no difference...
In many applications, it is of interest to assess the relative contribution features (or subsets features) toward goal predicting a response - in other words, gauge variable importance features. Most recent work on assessment has focused describing within confines given prediction algorithm. However, such does not necessarily characterize potential features, and may provide misleading reflection intrinsic value these To address this limitation, we propose general framework for nonparametric...
To report the neurologic outcomes in long-term survivors of out-of-hospital cardiac arrest with ventricular fibrillation as presenting rhythm (OHCA VF) at a population level.All adults who experienced OHCA VF Olmsted County, MN, from 1990 to 2008, survived more than 6 months postarrest, and were alive time study recruitment invited participate structured neuropsychological testing examination. Cognitive test results compared normal using Mayo's Older Adults Normative Studies. Linear...
<h3>Objective:</h3> To study the incidence and pattern of neurologic disorders in a large cohort HIV-positive men, compared with HIV-negative era highly active antiretroviral therapy (HAART). <h3>Methods:</h3> The Multicenter AIDS Cohort Study is prospective men who have sex enrolled 4 cities United States. We vs for category diagnoses HAART (July 1, 1996, to last known follow-up or death, on before July 2011). <h3>Results:</h3> There were 3,945 participants alive during (2,083 HIV negative,...
<h3>BACKGROUND AND PURPOSE:</h3> Oligodendrogliomas are tumors that have variable WHO grades depending on anaplasia and astrocytic components their treatment may differ accordingly. Our aim was to retrospectively evaluate imaging features of oligodendrogliomas predict tumor grade. <h3>MATERIALS METHODS:</h3> The studies 75 patients with were reviewed compared the histologic presence degree enhancement calcification evaluated subjectively. rCBV ADC maps measured. Logistic linear regression...
Objective Propensity score matching is typically used to estimate the average treatment effect for treated while inverse probability of weighting aims at estimating population effect. We illustrate how different estimands can result in very conclusions. Study design applied two propensity methods assess continuous positive airway pressure on mortality patients hospitalized acute heart failure. Monte Carlo simulations investigate important differences estimates. Results Continuous application...
Ophthalmic conditions and dementia appear to overlap may share common pathways, but research has not differentiated subtypes.Diagnoses of cataracts, age-related macular degeneration (AMD), diabetic retinopathy (DR), glaucoma were based on medical histories International Classification Diseases, Ninth Revision (ICD-9) codes for 3375 participants from the Cardiovascular Health Study. Dementia, including Alzheimer's disease (AD) vascular (VaD), was classified using standardized...
Abstract Objective The main aim of this study was to define the best treatment option for multisystem inflammatory syndrome in children (MIS-C) and analyse role anakinra. Methods This is a multicentre retrospective cohort study. Patients were treated according attending physician’s decision. patients divided into four groups on basis first at time admittance: (i) IVIG, (ii) IVIG methylprednisolone (≤2 mg/kg/day), (iii) with high-dose (&gt;2 mg/kg/day) (iv) anakinra or without and/or...
To determine the range and burden of health services utilization among Iraqi refugees receiving assistance in Jordan, a country first asylum.Medical conditions, diagnosed accordance with tenth revision International classification diseases, were actively monitored from 1 January to 31 December 2010 using pilot centralized database Jordan called Refugee Assistance Information System.There 27 166 medical visits by 7642 (mean age: 37.4 years; 49% male; 70% Baghdad; 6% disabled; 3% history...
<h3>BACKGROUND AND PURPOSE:</h3> We sought to compare the accuracy of a volumetric fully automated computer assessment hippocampal volume asymmetry versus neuroradiologists9 interpretations temporal lobes for mesial sclerosis. Detecting sclerosis (MTS) is important evaluation patients with lobe epilepsy as it often guides surgical intervention. One feature MTS loss. <h3>MATERIALS METHODS:</h3> Electronic medical record and researcher reports scans proved were compared an FDA-approved...
The broadly neutralizing antibody (bnAb) VRC01 is being evaluated for its efficacy to prevent HIV-1 infection in the Antibody Mediated Prevention (AMP) trials. A secondary objective of AMP utilizes sieve analysis investigate how prevention (PE) varies with envelope (Env) amino acid (AA) sequence features. An exhaustive that tests PE depends on every AA feature sufficient variation would have low statistical power. To design an adequately powered primary AMP, we modeled neutralization as a...